Clinics of Ocular Tuberculosis

Gupta, Vishali; Shoughy, Samir S.; Mahajan, Sarakshi; Khairallah, Moncef; Rosenbaum, James T.; Curi, André Luiz Land; Tabbara, Khalid F.

doi:10.3109/09273948.2014.986582

Cited by 144 publications

(129 citation statements)

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“…The difficulty in the management of TBU is contributed by its ability to affect any tissue in the eye 26,[28][29][30][31] and the need for cautious interpretation of investigations. [32][33][34][35][36][37][38][39][40][41] This leads to delay in targeted therapy and poorer treatment outcomes 24,42 that are yet further compounded by a lack of consensus on the management approach for TBU.…”

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confidence: 99%

Global Variations and Challenges With Tubercular Uveitis in the Collaborative Ocular Tuberculosis Study

Agrawal

Gunasekeran

Raje³

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. The aim of this study was to examine regional variation management practices and outcomes for tubercular uveitis (TBU). METHODS.In this retrospective multinational cohort study, patients from 25 international eye care centers diagnosed with TBU with a minimum follow-up of 1 year were included. The geographic variation in treatment outcomes on survival analysis in patients with TBU were analyzed. Treatment failure is defined as a persistence or recurrence of inflammation within 6 months of completing antitubercular therapy, the inability to taper oral corticosteroids to less than 10 mg/d or topical corticosteroid drops to less than 2 drops daily, and/or recalcitrant inflammation necessitating corticosteroid-sparing immunosuppressive therapy. RESULTS.Records of 945 patients (1485 eyes) with TBU were analyzed. The mean age was 41.3 6 15.0 years (range, 4-90 years), with more males (52.9%, n ¼ 500/945) and predominant Asian ethnicity (74.4%, n ¼ 690/927). Most patients had no symptoms (92.0%, n ¼ 655/712) or history (76.7%, n ¼ 604/787) suggestive of pulmonary tuberculosis (TB). Some patients had evidence of inactive pulmonary TB on chest X-rays (26.9%, n ¼ 189/702) or chest computed tomography (68.6%, n ¼ 109/159). Patients with western geographic origin (logrank ¼ 6.47, P ¼ 0.010), African or Hispanic ethnicity (log-rank ¼ 19.9, P < 0.001), and positive immigrant status (log-rank ¼ 4.89, P ¼ 0.027) had poorer survival outcomes.CONCLUSIONS. This is a first-ever multinational analysis of TBU that highlights regional differences in treatment outcomes for this elusive form of extrapulmonary TB. Our findings will help in the design of future collaborative studies together with internists to develop best practice guidelines for this early opportunity to address TB infection and strategies to target at-risk groups such as immigrants.

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confidence: 99%

Global Variations and Challenges With Tubercular Uveitis in the Collaborative Ocular Tuberculosis Study

Agrawal

Gunasekeran

Raje³

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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“…The lesion is focal and non-necrotising14 or may undergo scleral necrosis leading to scleral thinning 3. If not properly treated, the lesion may progress leading to scleral perforation 15. Diffuse scleritis may occur in patients with tuberculosis but is less common than nodular scleritis 3.…”

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confidence: 99%

Clinical manifestations and outcome of tuberculous sclerokeratitis

2015

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“…These varied presentations are thoroughly summarized by Dr Vishali Gupta et al in this issue of OII. 13 Five additional original articles, [14][15][16][17][18] one brief report 19 and four letters [20][21][22][23] in this issue of OII present important findings related to the diagnosis and treatment of tuberculous uveitis.…”

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confidence: 98%