Clinicoradiological Features of Pulmonary Cryptococcosis in Immunocompetent Patients

Choi, Hong Seok; Kim, Yun‐Hyeon; Jeong, Won Gi; Lee, Jong Eun; Park, Hye Mi

doi:10.3348/jksr.2022.0008

Cited by 1 publication

(2 citation statements)

References 13 publications

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“…In this case, the blood cryptococcal antigen was still positive in the outpatient follow-up up to 4 months. Several studies suggested that it took more than 1 year for the blood CrAg to turn negative in the adult department [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

“…Although the specificity is high, the sensitivity about 86% depends on the user, and it is inadequate for detecting early fungal infection [31]. In recent years, CrAg test, a rapid and sensitive diagnostic method, has received increasing attention as a novel diagnostic tool for PC [32] and recommended by guideline [33]. However, in some cases of non-disseminated PC, CrAg may not be detected despite the presence of infection [7].…”

Section: Discussionmentioning

confidence: 99%

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Cryptococcosis with pulmonary cavitation in an immunocompetent child: a case report and literature review

Dai,

Wang,

Ying

et al. 2024

BMC Infect Dis

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Background Pulmonary cryptococcosis (PC) rarely occurs in immunocompetent children. Case presentation A 13-year-old boy was admitted to the First Affiliated Hospital of Ningbo University in February 2023 with complaints of cough and chest pain. Physical examination showed slightly moist rales in the right lung. Chest computed tomography (CT) suggested a lung lesion and cavitation. Blood routine test, lymphocyte subsets, immunoglobulin, and complement tests indicated that the immune system was normal. However, the serum cryptococcal antigen test was positive. Next-generation sequencing revealed Cryptococcus infection. The child was diagnosed with PC and was discharged after treating with fluconazole 400 mg. Four months later, chest CT showed that the lung lesion diminished, and reexamination of serum cryptococcal antigen test turned positive. Conclusion PC should be considered in an immunocompetent child with pulmonary cavities with nonspecific symptoms.

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Section: Discussionmentioning

confidence: 99%