Clinicopathological study of new onset pancytopenia: An experience of largest study from a tertiary care center of western India

Pendkur, Ganesh; Singhal, Paresh; Somasundaram, Venkatesan; Raghavendra, S K; Sharma, Sanjeevan

doi:10.4103/mjdrdypu.mjdrdypu_158_20

Med J DY Patil Vidyapeeth

2021

DOI: 10.4103/mjdrdypu.mjdrdypu_158_20

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Clinicopathological study of new onset pancytopenia: An experience of largest study from a tertiary care center of western India

Ganesh Pendkur

Paresh Singhal

Venkatesan Somasundaram

et al.

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Assessment of the Clinic-pathological Profile of Patients with Pancytopenia

Tiwari,

Kaushal,

Chowdhary

et al. 2023

Acta Medica International

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Introduction: Pancytopenia is an important clinico-hematological condition encountered in day-to-day clinical practice. Pancytopenia is often very difficult to diagnose and treat often owing to its varied aetiologies, causes might ranging from infections, nutritional deficiencies to malignancies. Materials and Methods: This was a cross-sectional study conducted in Department of General Medicine, Rohilkhand Medical College and Hospital, Bareilly. Patients’ information was filled in pro forma, and contains patient’s age, gender, clinical features, clinical findings, CBC findings, bone marrow findings, and diagnosis from all patients collected. Detailed clinical history and clinical examination along with blood investigation were carried out. Results: In the present study, the mean level of platelets was 54,000 ± 31,549/µL, with a minimum level of 2000/µL and a maximum level of 130,000/µL, indicating that majority of patients suffered from thrombocytopenia. The mean level of white blood cells (WBCs) was 2873.4 ± 780.4/µL, with a minimum level of 1000/µL and a maximum level of 3860/µL, indicating that all the patients suffered from leukopenia. 30% of patients had normocytic normochromic RBC, 24% had macrocytic normochromic RBC, 22% had macrocytic hyperchromic, 6% had microcytic normochromic, 8% had microcytic hypochromic, and 10% had both macrocytic and microcytic RBCs. Conclusion: Mean values of Hb, WBC & Platelet count was non-significantly higher among female patients comparing to males, though mean value of MCV was non-significantly higher in male patients comparing to females.

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Assessment of the Clinic-pathological Profile of Patients with Pancytopenia

Tiwari,

Kaushal,

Chowdhary

et al. 2023

Acta Medica International

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Clinico-pathological profile of pancytopenia patients in a single health care centre of northern India

Bhushan

Roy

Agarwal

2022

Journal of Family Medicine and Primary Care

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Background: Pancytopenia is a clinical outcome of various pathological conditions ranging from bone marrow suppression, bone marrow infiltration, infections, hypersplenism, haemolysis, and haematological malignancies. As such is the most common cause in drug induced (chemotherapy) bone marrow suppression. As most of these patients first contact their primary care physicians, a quick workup will resolve many diagnosis and can give a hint towards a life threatening condition too. Material and Methods: We included all patients admitted with pancytopenia at our tertiary care centre except those who were drug induced. They were evaluated and given appropriate treatment. Results: We observed 73 patients in a year, after excluding drug-induced pancytopenia, and showed aplastic anaemia was the foremost cause (31.5%) followed by vitamin B12 deficiency (19.2%), infections (13.7%), hypersplenism and haematological malignancies. Conclusion: Majority of adult patients admitted with pancytopenia are diagnosed to have curable cause like vitamin deficiency and infections but significant number was also of aplastic anaemia, a condition that requires specialist care.

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Clinicopathological study of new onset pancytopenia: An experience of largest study from a tertiary care center of western India

Cited by 2 publications

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Assessment of the Clinic-pathological Profile of Patients with Pancytopenia

Assessment of the Clinic-pathological Profile of Patients with Pancytopenia

Clinico-pathological profile of pancytopenia patients in a single health care centre of northern India

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