Clinicopathological study of neurofibromatosis type 1: an experience in Nigeria

Odebode, TO; Afolayan, Eao; Adigun, IA; Daramola, O O M

doi:10.1111/j.1365-4632.2004.02386.x

Cited by 8 publications

(11 citation statements)

References 8 publications

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“…found the sex distribution to be equivalent, but Nguyen et al . and Odebode et al . reported that, among patients diagnosed with NF1, there was a higher proportion of women.…”

Section: Discussionmentioning

confidence: 98%

Anthropometric characteristics and comorbidities in Japanese patients with neurofibromatosis type 1: A single institutional case–control study

Koga

Nakayama

et al. 2014

The Journal of Dermatology

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Neurofibromatosis type 1 (NF1) is a well-known genetic disorder characterized by café-au-lait spots and neurofibromas, but many other clinical characteristics and associated comorbidities also have been reported. This study aimed to characterize NF1 further by investigating its association with anthropometric characteristics and other diseases. We performed a case-control study of 227 NF1 patients (101 male, 126 female) and a randomly selected age- and sex-matched control group of 681 non-NF1 patients (303 male, 378 female) who visited our institution in Japan. We examined adult (≥20 years) height and body mass index (BMI), and, in the total sample, allergic diseases (bronchial asthma [BA], atopic dermatitis [AD] and allergic rhinitis) and other respiratory cardiovascular and psychiatric disorders. In adults, the mean BMI was lower in the NF1 group than in the control group, and was significantly statistically different among men (P = 0.0238). In the whole sample, the prevalences of BA (P = 0.0184), AD (P = 0.0144) and valvular heart disease (P = 0.0166) were significantly greater in the NF1 group than in the control group. To date, no similar research on the BMI or the prevalence of allergic disease in NF1 patients has been reported. Our results suggest that NF1 patients tend to have lower BMI and may have alterations in specific metabolic pathways and altered allergic immunity.

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“…found the sex distribution to be equivalent, but Nguyen et al . and Odebode et al . reported that, among patients diagnosed with NF1, there was a higher proportion of women.…”

Section: Discussionmentioning

confidence: 98%

Anthropometric characteristics and comorbidities in Japanese patients with neurofibromatosis type 1: A single institutional case–control study

Koga

Nakayama

et al. 2014

The Journal of Dermatology

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“…This may be due to the fact that café au lait spots are the first signs of the disease [3]. In adolescence, they are present in more than 99% of cases, in adult life they often become paler, inconspicuous and some disappear [15]. Neurofibromas were present in all 3 patients.…”

Section: Discussionmentioning

confidence: 99%

Neurofibromatosis Type 1 or Von Recklinghausen Disease: About Three Cases to the National Hospital of Niamey and Literature Review

Daou¹,

Sidibé²,

Andia³

et al. 2021

OJIM

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We report three cases of neurofibromatosis type 1 disease with literature review, collected in the department of neurology and internal medicine from National Hospital of Niamey (HNN). Two of them were men and the first signs were noted by the mother at the birth in 2 cases. Only one case of consanguinity was observed. Clinically, light brown spots on the skin, neurofibromas, Lisch nodules were constantly observed. Histopathological's exam confirmed neurofibromas. Moreover, cutaneous and ophthalmological manifestations lead to the diagnostic. Two cases of orthopedic complications were observed: one scoliosis and one Congenital dysplasia of the long bones. There was no specific treatment. Neurofibromatosis type 1 or von Recklinghausen's disease is the most frequent phacomatosis and its diagnosis is usually composed of a set of clinical criteria of the National Institute Health (Bethesda, 1988).

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“…Solitary neurofibromas are superficial, painless and slow growth reaching variable sizes [22,23] and, particularly, they clinically present after the puberty and remain their progressive growth throughout life [19][20][21][22][23]. As part of the NF-1, deeper and visceral or plexiform neurofibromas as well as their malignant transformation, which is more common in neurofibromas than schwannomas, may be observed [11,[19][20][21][22][23][24][25][26][27]. Oral sites more affected are the tongue, buccal mucosa and lips.…”

Section: Introductionmentioning

confidence: 99%

A 38-year review of oral schwannomas and neurofibromas in a Brazilian population: clinical, histopathological and immunohistochemical study

et al. 2010

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The benign peripheral nerve sheath tumours are rare lesions mainly represented by schwannoma and neurofibroma. The present work evaluated the clinical and histopathological features of schwannomas and neurofibromas of the oral cavity diagnosed in a Brazilian population. Among 9.000 cases of oral lesions archived from 1970 to 2008, four schwannomas and 12 neurofibromas were identified, microscopically revised and immunohistochemically certified through a panel including monoclonal antibodies (anti-S100, vimentin, HHF-35 and desmin). From biopsy and histological sections records, clinical and histopathological data were retrieved, reviewed and statistically analysed. Predominantly, schwannomas affected non-white males (3:1), with an age and size averages of 34.7 years and 2.8 cm, respectively. Neurofibromas preferentially occurred on the gingival/alveolar ridge of white females (5:1), with 35.7-year mean age, peak of incidence between 3rd and 5th decade, and size average of 1.7 cm. (12 cases, 75%). The studied tumours exhibited more frequently as a painless, sessile and slow growth very similar to other oral lesions, but their microscopic features differed significantly. Schwannomas and neurofibromas are extremely uncommon in the oral cavity, exhibiting clinical features very similar but specific and peculiar microscopic findings that are useful in the establishment of the diagnosis, which in some particular cases must be confirmed by immunohistochemistry.

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Clinicopathological study of neurofibromatosis type 1: an experience in Nigeria

Cited by 8 publications

References 8 publications

Anthropometric characteristics and comorbidities in Japanese patients with neurofibromatosis type 1: A single institutional case–control study

Anthropometric characteristics and comorbidities in Japanese patients with neurofibromatosis type 1: A single institutional case–control study

Neurofibromatosis Type 1 or Von Recklinghausen Disease: About Three Cases to the National Hospital of Niamey and Literature Review

A 38-year review of oral schwannomas and neurofibromas in a Brazilian population: clinical, histopathological and immunohistochemical study

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