Clinicopathological study of male breast carcinoma: 24 years of experience

Abstract

BACKGROUND AND OBJECTIVES:Because breast cancer in men is rare, few patients are available for prospective studies. To learn more about its epidemiology, risk factors, clinical features, genetics and pathology in our country, we conducted a retrospective study of all cases seen in recent decades at our institution.PATIENTS AND METHODS:We identified each case of male breast cancer in the database at the Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Kashmir, India, between the years 1983 to 2007.RESULTS:We identified only 32 cases of male breast cancer over the 24-year period. Male breast cancer accounted for 32 (2.8%) of 1141 resected breast specimens, which included all breast lesions and 32 (4.1%) of 780 breast cancer cases. Of the 32 cases, 20 (62.5%) had various associated risk factors. Invasive ductal carcinoma was seen in 30 cases (93.7%). Of 20 cases that underwent molecular studies, 16 (80%) patients had estrogen receptor positivity whereas 14 (70%) had progesterone receptor positivity. Six cases (30%) overexpressed HER2 and p53. The BRCA2 mutation was observed in 4 cases (40%) while no patient presented with the BRCA1 mutation.CONCLUSION:An incidence of 4.1% for male breast cancer indicates that this disease is not as uncommon as presumed in this part of the world. Breast cancer in men seems more frequently to be hormone receptor positive and the BRCA2 mutation confers a significant risk to men.

Male Breast Cancer: A Single Centre Experience and Current Evidence

“…The worldwide variation in male breast cancer is similar to breast cancer in women, with higher rates in North America and Europe and lower rates in Asia (5). Rates of male breast cancer in India, Uganda, and Zambia are 5% and 15%, respectively (6,7). These relatively high rates have been attributed to endemic infectious diseases causing liver damage leading to hypoestrogenism (6).…”

Clinicopathological characteristics of male breast lesion: An experience in a regional cancer center, Odisha

“…Chikaraddi et al [2] have reported an incidence rate of 0.4 % of all breast cancer. A study conducted by Rai et al, [12] from North India, revealed the incidence of MBC as 0.5% while Shah et al [13] have reported a relatively high incidence of 4.1% from Kashmir. In our study, the prevalence of MBC in this study was 1.34%, among all MBC cases and 2.50%, among all breast lesion which is similar to the study conducted by Sundriyal et al [14] and Mitra et al [15] The prevalence of MBC increases with age.…”

Incidence and Clinical Presentation of Male Breast Cancer at Regional Cancer Center of India

“…Chikaraddi SB et al [5] have reported an incidence rate of 0.4% of all breast cancer. Another study Rai B et al [6] from north india, revealed the incidence of male breast cancer as 0.5% while Shah P et al have reported a relatively high incidence of 2.8% of total resected breast specimen [7] .…”

“…Because of its low incidence and rarity of disease the epidemiological data regarding male breast cancer is little as compared to female counterpart. In India only few studies are available regarding incidence, presentation, course and prognosis of male breast cancer [5][6][7] . This study was aimed to analyse incidence and clinical presentation of male breast cancer at regional cancer center of India.…”