Clinicopathological study of carcinomas of the lip and the mucosa of the upper and lower lips

Ogura, Ichiro; Amagasa, Teruo; Iwaki, Hiroshi; Kijima, Takeshi; Kurabayashi, Tohru; Yoshimasu, Hidemi

doi:10.1007/pl00012093

Cited by 7 publications

(8 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The survival of SCC patients is higher in this study compared with the USA. This may be due to this study including lip SCC (excluded in the US data), which usually has a good prognosis, with a 45–72% 5‐year survival rate (36, 37). Of all oral tumors, melanoma presents the worst survival.…”

Section: Discussionmentioning

confidence: 99%

Oral cancer over four decades: epidemiology, trends, histology, and survival by anatomical sites

Zini¹,

Czerninski

Sgan‐Cohen³

2010

J Oral Pathology Medicine

224

169

View full text Add to dashboard Cite

BACKGROUND: Oral cancer is one of the few lifethreatening oral diseases. The subtypes and different sites of oral cancer has different etiology epidemiology and survival rate. Prevalence of the various anatomical oral sites provided potential baseline for improvement of clinical approach. METHODS: Incidence and survival rates were derived from the Israel National Cancer Registry and included all registered data between 1970 and 2006. Oral cancer included the lips, tongue, buccal mucosa, gums, vestibulum, floor of the mouth, and palate. RESULTS: Most prevalent oral cancer subtype was squamous cell carcinoma (SCC) among men above the age of 55 years. Females had a higher incidence of SCC in lateral border of tongue, gums and buccal mucosa. Lymphoma and sarcoma were the most prevalent under the age of 20. Melanomas and metastatic disease revealed the lowest survival rate, while invasive or infiltrating basal cell carcinoma in the lips had the highest rate. The highest oral survival rate was for the lip, and the lowest was for the tongue and gums. CONCLUSIONS: Early detection of oral cancer is important for all the medical health team. Decrease in lip carcinoma may be a result of occupational or awareness changes and should be studied. Non-epithelial tumors under the age of 20 should be considered as a differential diagnosis. A basic oral examination should be included in all routine medical examinations, with emphasis on highrisk patients and high-risk oral sites.

show abstract

Section: Discussionmentioning

confidence: 99%

Oral cancer over four decades: epidemiology, trends, histology, and survival by anatomical sites

Zini¹,

Czerninski

Sgan‐Cohen³

2010

J Oral Pathology Medicine

224

169

View full text Add to dashboard Cite

show abstract

“…16 presented 82.5%, despite the fact that his study had 75% of the lesions with clinical staging I and about 43% were well differentiated. In our study 60% of the lesions were in stage I and 30% were well differentiated, despite that survival rate was higher (89.6%).…”

Section: Discussionmentioning

confidence: 80%

“…described in 1983 14 a possible link between HPV and oral cancer due to the observation of cytopathic alterations in oral lesions similar to those typically induced by HPV previously found in cervix cancer. Regarding the significance of HPV DNA presence in prognosis of patients with oral SCC, literature data are controversial [15][16][17][18] . However, its has been suggested differences between patients infected and no infected with HPV in relation to sex, age, tumor regions, histological grade, regional metastasis, rate of recurrence and survival 18 .…”

mentioning

confidence: 99%

Human papillomavirus (HPV) detection in lip squamous cell carcinoma: correlation with clinical aspects and risk factors

Demathé

Garcia

Mattar³

et al. 2011

Rev. bras. epidemiol.

View full text Add to dashboard Cite

. According to IARC 5 lip cancer incidence in Brazil for 2007 ranging of 0.8/100,000 (Brasília) to 1.4/100,000 (São Paulo) for man and ranging 0.1/100,000 (Cuiabá) to 0.5/100,000 (Goiânia) for woman.The highest prevalence of lip SCC occurs between the sixth and seventh decades of life. The lower lip is the oral site more affected by SCC and usually diagnosed in stage I 7 . South of Australia is among the regions with the highest incidence of lip SCC, with 13.49 cases/100,000 inhabitants/year in men and 3.21 cases/100,000 inhabitants/year in women. In Europe, specifically in Spain, lip SCC represents a major impact on men (12.70 cases/100,000 inhabitants/year), and in Switzerland presents the highest incidence in women (0.83 cases/100,000 inhabitants/ year) 8 . In France, the lip, mouth and pharynx cancer incidence reaches 38.5/100,000 9 . In Brazil, according to the estimate of National Institute of Cancer for 2008, the incidence of oral cancer was 14.45/100,000 in men and 4.83/100,000 in women non-smokers and non-drinkers suggesting that other factors, including certain viruses, may have implications on the oral carcinogenesis 11,12 . Among the viruses that appear to be related to oral cancer etiology is the human papillomavirus (HPV) [11][12][13] . HPV role in the etiology of cervix carcinoma is clear, however its participation on carcinogenesis in oral cavity and other anatomical sites such skin, esophagus, paranasal conjunctiva, bronchus, larynx, oropharynx only is suggested 13 . Syrjänen and cols. described in 1983 14 a possible link between HPV and oral cancer due to the observation of cytopathic alterations in oral lesions similar to those typically induced by HPV previously found in cervix cancer. Regarding the significance of HPV DNA presence in prognosis of patients with oral SCC, literature data are controversial [15][16][17][18] . However, its has been suggested differences between patients infected and no infected with HPV in relation to sex, age, tumor regions, histological grade, regional metastasis, rate of recurrence and survival 18. Due to the great controversy in the literature, further studies are needed to help clarify the remaining questions that still persist. The aim of this study was to investigate HPV DNA presence in biopsies of lip SCC and correlate with clinical aspects and risk factors. Materials and MethodsThis study was reviewed and approved by Research Ethics Committee of São Paulo State University -Dentistry School of Araçatuba. Thirty-three caucasian patients presenting lip SCC confirmed by histological diagnosis participated in the study.A questionnaire was completed at the initial patient trial asking about age, sex, occupation, tobacco and alcohol consumption and sun exposure. If the patient had oral cancer and none of this risk factors above the risk factor is described as "other risk factors". Smokers were considered those that smoked regularly during any time of life, even those who stopped. Non-smokers were those who never used tobacco. The same criteria were used f...

show abstract

“…Dear Editor, Although mucoepidermoid carcinoma (MEC) is the most common tumor of salivary tissues, MEC of the skin is rare. 1,2 MEC should be considered in the differential diagnosis of tumors of the lip, such as squamous cell carcinoma (SCC). We recently applied dermoscopy to MEC of the lip and present the usefulness of dermoscopy for classifying MEC.…”

mentioning

confidence: 99%

Dermoscopic features of mucoepidermoid carcinoma of the lip

Kawaguchi

Murata

Suzuki

2017

The Journal of Dermatology

View full text Add to dashboard Cite

Dear Editor, Although mucoepidermoid carcinoma (MEC) is the most common tumor of salivary tissues, MEC of the skin is rare. 1,2 MEC should be considered in the differential diagnosis of tumors of the lip, such as squamous cell carcinoma (SCC). We recently applied dermoscopy to MEC of the lip and present the usefulness of dermoscopy for classifying MEC.A 55-year-old Japanese man was admitted to our hospital with a mass on his upper lip. He had noticed the skin lesion 2 years earlier. The mass was a whitish nodule of 14 mm in diameter and firm in consistency ( Fig. 1a). Dermoscopic examination showed the presence of structureless white areas, yellow-white opaque scales, and dotted and linear-irregular vessels in the lesion (Fig. 1b). We also noted multiple white clods mimicking milia-like cysts. The white clods were peripherally located around the structureless white central areas ( Fig. 1b). There were no enlarged cervical lymph nodes. Histological examination of a biopsy specimen taken from the lesion showed the characteristic histological features of MEC, being composed of a combination of squamoid cells, intermediate cells, mucocytes, and cystic and tubular structures of varying sizes ( Fig. 1c-e). Computed tomography revealed no evidence of metastasis. We removed the lesion surgically with a 5-mm border, by V-excision following local anesthesia. After a 2-year follow up, there was no evidence of local recurrence or metastasis.The clinical features of MEC resemble SCC. Although most MEC arise on the upper lip, SCC usually develops on the lower lip. Here, we examined the differences of dermoscopic features between MEC and SCC, which had not been described previously. We observed that there was significant similarity in the dermoscopic patterns between MEC and SCC. Structureless white areas, yellow-white opaque scales, and dotted and linear irregular vessels were seen in MEC (Fig. 1b), which are dermoscopic characteristics of SCC. 3 In this study, we noted multiple white clods mimicking milia-like cysts that are often seen in seborrheic keratosis, as a characteristic finding in MEC. Although white clods are also seen in SCC and histopathologically correspond to horn peals, it is a rare feature. 4 We found from histological examination that the white clods corresponded to cystic components filled with mucinous material in MEC (Fig. 1c,d). One of the histopathological features correlated with poor outcome is the presence of less than 20% of cystic components in MEC. 5 MEC can be classified into low, intermediate and high grades based on the following parameters: cystic components, neural invasion, anaplasia, mitosis and necrosis. Low-grade MEC has a good prognosis and more cystic components than high-grade MEC. Therefore, it is suggested that the feature of multiple white clods is an important dermoscopic indicator of good prognosis in MEC. Although biopsy is needed for precise diagnosis in case it is difficult to discriminate MEC from SCC, dermoscopy is more useful than biopsy to evaluate the rate of cystic compon...

show abstract

Clinicopathological study of carcinomas of the lip and the mucosa of the upper and lower lips

Cited by 7 publications

References 14 publications

Oral cancer over four decades: epidemiology, trends, histology, and survival by anatomical sites

Oral cancer over four decades: epidemiology, trends, histology, and survival by anatomical sites

Human papillomavirus (HPV) detection in lip squamous cell carcinoma: correlation with clinical aspects and risk factors

Dermoscopic features of mucoepidermoid carcinoma of the lip

Contact Info

Product

Resources

About