Clinicopathological study of bronchogenic carcinoma

Prasad, Rajendra; James, Prince; Kesarwani, Vikas; Gupta, Richa; Pant, M. C.; Chaturvedi, Arun; Shrivastava, Anand N.

doi:10.1111/j.1440-1843.2004.00600.x

Cited by 40 publications

(41 citation statements)

References 9 publications

(13 reference statements)

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“…Hence the importance of tobacco cessation programmes in the community as well as mass education and awareness programme among adolescents should be strongly implemented. The proportion of lung cancer incidence among non-smokers is approximately 20%, which correlates with other studies conducted in India (Rajasekaran et al, 1993;Gupta et al, 1998;Prasad et al, 2004).…”

Section: Discussionsupporting

confidence: 86%

“…The present study showed inconsistent results on the distribution of histologic type of cancer compared with the other studies conducted within India (Gupta et al, 1998;Thippanna et al, 1999;Khan et al, 2006;Prasad et al, 2009;Singh et al, 2010). However several studies have pointed out that majority of the lung cancer cases were diagnosed in the advanced stages of the disease (Thippanna et al, 1999;Prasad et al, 2004;Mohan et al, 2007).…”

Section: Discussioncontrasting

confidence: 70%

“…The present study reveals that about 91% of the male cases had smoking habit; whereas among females smoking is comparatively less, but the influence of passive smoking is significantly remarkable. The increased proportion in smoking status correlates with the studies from other developing nations (Chandrasekhar et al, 2006;Hassan et al, 2010) and report from different parts of India (Gupta et al, 1998;Prasad et al, 2004Prasad et al, : 2009Khan et al, 2006;Rawat et al, 2009;Singh et al, 2010). Higher prevalence of tobacco use among male could be due to easiness in availability and cheaper cost of such items.…”

Section: Discussionsupporting

confidence: 57%

“…Relatively high, but inconsistent male to female ratio were observed in a few studies (Thippanna et al, 1999;Prasad et al, 2004;Singh et al, 2010). High incidence of lung cancer in males could be due to high level consumption of tobacco in any form and the prevalence of tobacco habits among females is very low compared to males in Kerala.…”

Section: Discussionmentioning

confidence: 98%

See 3 more Smart Citations

Lung Cancer in Malabar Cancer Center in Kerala - A Descriptive Analysis

Bhaskarapillai

Kumar²,

Balasubramanian³

2012

Asian Pacific Journal of Cancer Prevention

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The burden of lung cancer in terms of mortality is the highest among all types of cancers globally. The present study aimed to evaluate lifestyle related habits, clinico-pathological profile and treatment details of lung cancer patients who were registered at Malabar Cancer Centre (MCC), Kerala, during the calendar year 2010. A retrospective evaluation was made from medical records to gather data from 281 registered lung cancer cases in 241 males and 40 females, with a male to female ratio of 6.03: 1. Approximately 89% of the cases were above 50 years of age. Among males about 91% of the cases were smokers and 62% of them had a chronic smoking habit. Adenocarcinomas, squamous cell carcinomas, non-small cell carcinomas and small cell cancers accounted for 10.7, 13.9, 17.0 and 5.7% respectively. Out of 281 cases around 67% were diagnosed with distant metastasis and the remainder had regional lymph node involvement. However, no statistically significant difference was observed for secondary site of tumor according to gender. As majority of the cases reported at MCC were in an advanced stage of the disease, histology of the secondary site from supraclavicular lymph nodes or liver was taken for diagnosis. Initiation of population based screening for early detection of cancer, and primary and secondary prevention strategies for reducing the prevalence of tobacco consumption are high priorities to reduce the lung cancer burden in Kerala.

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Section: Discussionsupporting

confidence: 86%

Section: Discussioncontrasting

confidence: 70%

Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 98%

See 2 more Smart Citations

Lung Cancer in Malabar Cancer Center in Kerala - A Descriptive Analysis

Bhaskarapillai

Kumar²,

Balasubramanian³

2012

Asian Pacific Journal of Cancer Prevention

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“…6 Another study by Prasad R et al reported the mean age to be 57 years. 7 The male to female ratio was 2.4: 1. The ratio was lower compared to the other Indian studies where the male to female ratio varied from 4.5:1 to 7.8:1.…”

Section: Discussionmentioning

confidence: 96%

Does a routine post brush bronchial wash increase the yield in diagnosis of lung cancer?

Raj

Murali

2017

Int J Res Med Sci

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Background: Lung cancer is the most common cause of cancer-related death in both men and women. 80% of the lung cancers are non-small cell lung cancer (NSCLC) and 20% are small cell lung cancer (SCLC). Flexible fiberoptic bronchoscopy is commonly used for diagnostic and staging purposes. Endoscopically visible abnormalities are approached with traditional biopsy forceps, brushings, and washings. Objectives were to assess the yield of bronchial washings, brush cytology and to compare the yield of pre and post brush bronchial washings.Methods: Patients with suspicion of lung cancer will be subjected to bronchoscopy using flexible fibreoptic bronchoscopy. Multiple procedures performed for the retrieval of tissue samples will include bronchial washings (pre and post brushing), bronchial brushing and endobronchial biopsy.Results: A total of 57 cases were included in the study with 40 (70.2%) males and 17 females (29.8%). The yield of pre-brush bronchial washings, post brush bronchial washings and bronchial brushings were 31.6% (18 of 57), 31.6% (18 of 57) and 61.4% (35 of 57) respectively. Biopsy was positive for malignancy in 11 of 19 (58.2%) cases. Adenocarcinoma was the commonest type seen in 32 (56.1%) patients. Of the 27 cases with endobronchial growth 11 were adenocarcinoma (40.7%).Conclusions: There was no difference between the yield of pre-brush washing and post brush washing. The yield of brush cytology was significantly more than the yield of bronchial washings. There is an increase in the yield after adding both pre and post brush bronchial wash.

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Comparative analysis of various cytohistological techniques in diagnosis of lung diseases

Garg

Handa

Mohan

et al. 2006

Diagnostic Cytopathology

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A prospective study was conducted on 100 patients divided in two groups who underwent fiberoptic bronchoscopy (FOB). Group I consisted of 60 cases of suspected lung malignancy on clinical and radiological examination, while group II consisted of 40 cases of nonneoplastic lung diseases. Pre-FOB sputum, bronchoalveolar lavage (BAL), and bronchial brushing (BB) were done in all the cases, while forceps biopsy (FB), transbronchial needle aspiration (TBNA), and transthoracic needle aspiration were done in 56, 25, and 15 patients, respectively. BB and FB showed a sensitivity of 70.83 and 70% respectively in the diagnosis of malignancy. BAL was found to be positive in 37.5% patients. TBNA had the highest sensitivity of 83.33% whereas pre-FOB sputum and post-FOB sputum were positive only in 27.58 and 29.06% cases. In nonneoplastic group, BAL showed sensitivity of 80 and 83.33% in diagnosing tuberculosis and fungal diseases whereas BB was positive in 60 and 66.66% patients, respectively. Thus a combination of various cytohistological techniques results in a statistically significant increase in the diagnostic yield of various neoplastic and nonneoplastic lung diseases. BB, FB, and TBNA are complimentary in diagnosis of various lung malignancies whereas BAL is a useful procedure in detection of infectious diseases.

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Clinicopathological study of bronchogenic carcinoma

Abstract: Bidi smoking is an important contributory factor in the development of bronchogenic carcinoma in India, and approximately 25% of patients with bronchogenic carcinoma are non-smokers.

Cited by 40 publications

References 9 publications

Lung Cancer in Malabar Cancer Center in Kerala - A Descriptive Analysis

Lung Cancer in Malabar Cancer Center in Kerala - A Descriptive Analysis

Does a routine post brush bronchial wash increase the yield in diagnosis of lung cancer?

Comparative analysis of various cytohistological techniques in diagnosis of lung diseases

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