Clinicopathological studies on thyroglossal duct remnant

Kuroda, Takai; Iwasa, Takehiko; Miyakawa, M; Makiuchi, M.; Furihata, Rikio

doi:10.1007/bf02468713

Cited by 4 publications

(6 citation statements)

References 4 publications

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“…Clinical manifestation of TGDC based on a mid-year mean patient population of 3,064,661 patients for Southern California Permanente Medical Group would correspond to 2.23/100,000 population at risk each year. In our series, TGDC showed no gender predilection, a finding similar to the literature [3,[8][9][10][11][12][13]. However, males tended to predominate in pediatric patients while females predominated in adults.…”

Section: Discussionsupporting

confidence: 90%

“…Thyroglossal duct remnant cysts (TGDC) are among the most common cervical lesions encountered in infancy and childhood [6,7], although they not infrequently present in adults [8][9][10][11][12][13]. The cysts may arise anywhere along the migratory pathway of the thyroglossal duct of the developing thyroid gland.…”

Section: Introductionmentioning

confidence: 99%

“…Although multiple studies have addressed the clinical features of TGDC, few have included a detailed analysis of the associated pathologic findings [8,[13][14][15][16][17][18][19][20]. To date, there has been no large community practice based series evaluating TGDC histologically compared with management outcomes.…”

Section: Introductionmentioning

confidence: 99%

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A Clinicopathologic Series of 685 Thyroglossal Duct Remnant Cysts

Thompson¹,

Herrera²,

Lau³

2016

Head and Neck Pathol

102

104

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The clinical features of thyroglossal duct remnant cysts (TGDC) have been well described, however the histopathologic aspects of these lesions have not been addressed in a detailed manner. In particular, there has been no large community practice based series evaluating TGDC histologically compared with management outcomes. A retrospective review of all TGDC diagnosed between 2005 and 2015 was performed. Six hundred eighty-five patients were identified (344 males; 341 females). Age at presentation was bimodal (first and fifth decades) and ranged from 0.8 to 87 years (mean 31.3 years). Males predominate in children (150:111); females in adults (230:194). Patients presented most frequently with a mobile midline neck mass in an infrahyoid location. An associated skin fistula (n = 67) was twice as common in pediatric as adult patients. The average cyst size was 2.4 cm (range 0.4-9.9 cm) by imaging studies and 2.6 cm (range 0.2-8.5 cm) by pathologic examination; pediatric patients had smaller cysts (mean 2.1 cm) than adults (mean 2.8 cm). Histologically, 257 (38 %) TGDC were lined by respiratory epithelium alone, 68 (10 %) squamous epithelium alone, 347 (51 %) exhibited both respiratory and squamous epithelium, and 13 (1 %) had no identifiable epithelial lining. Four hundred eighty-four (71 %) TGDC had associated thyroid gland tissue present within the cyst wall (n = 282), skeletal muscle (n = 71), adipose tissue (n = 34), or a combination of these sites (n = 97). The hyoid bone was identified in 647 (grossly and/or histologically), and absent in 38. Surgical management consisted of Sistrunk procedure (n = 647), cystectomy (n = 31), or thyroidectomy/thyroid lobectomy (n = 7). Treatment related complications were observed in 6 patients, which included vocal cord damage, seroma, and hematoma. Recurrences developed in 20 (3 %) patients, 14 of whom were managed initially by cystectomy. Papillary thyroid carcinoma was identified in 22 (3.2 %) TGDC. In summary, TGDC show a bimodal peak in the 1st and 5th decades, commonly presenting as a midline cervical lesion below the hyoid bone, associated with a skin fistula in 10 %. Histologically TGDC are most commonly lined by a combination of respiratory and squamous epithelium. Thyroid gland tissue is identified in 71 % of cases (0.45 cm mean size), although not limited to the cyst wall, but present in the surrounding soft tissues. Rare TGDC may harbor malignancy (3.2 %). TGDC are most effectively managed by Sistrunk procedure rather than excision, which carries low rates of complications (1 %) and recurrence (3 %).

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Clinicopathologic Series of 685 Thyroglossal Duct Remnant Cysts

Thompson¹,

Herrera²,

Lau³

2016

Head and Neck Pathol

102

104

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“…Although they can be seen at any time, they occur most frequently in the first ten years, and the ratio of women to men is the same [4]. When we looked at the literature, it was observed that there was no significant difference between the male and female sexes [5,6]. Thyroglossal duct remnants have been reported in approximately 7% of the adult population [7].…”

Section: Discussionmentioning

confidence: 95%

Our Surgery Experience with Thyroglossal Ductus Cyst and Fistules

Dedeoğlu

2022

AJBSR

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“…Because of its relationship to both the hyoid bone and foramen cecum, the cyst typically moves cranially with swallowing and protrusion of the tongue. These manoeuvres may be difficult to elicit in small children [6]. Thyroglossal duct remnants are lined by ductal epithelium and may contain solid thyroid tissue.…”

Section: Introductionmentioning

confidence: 99%

The Relationship Between the Location of Thyroglossal Duct Cysts and the Epithelial Lining

Ali

Al-Jandan

Suresh

et al. 2012

Head and Neck Pathol

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Thyroglossal duct cysts (TDCs) with ambiguous epithelial lining are the most common midline cervical anomaly encountered in children. To histopathologically study the epithelial lining of 32 thyroglossal duct cysts in relation to their locations. A total of 32 cases of thyroglossal duct cysts were collected for this study. The samples were classified into 3 groups as follows: (1) above the hyoid bone; (2) at the level of hyoid bone; (3) below the hyoid bone. All samples were H&E stained. Seventeen TDCs (53 %) were found above the hyoid bone, 6 (18.8 %) were found at the level of hyoid bone and 9 (28.1 %) were found below the hyoid bone. Of the 32 total cases, 6 (18.8 %) were lined with stratified squamous epithelium (SSE), 17 (53 %) were lined with pseudostratified ciliated epithelium (PSCE), 3 (9.4 %) were lined with stratified cuboidal epithelium (SCE), and 6 (18.8 %) exhibited both SSE and PSCE. Pseudostratified ciliated epithelium was dominant in the region superior to the hyoid bone, whereas SCE was detected only in TDCs at the level of hyoid bone. These differences were statistically significant (P = 0.0001). Different types of epithelial lining were detected in the study samples of TDCs. A statistically significant correlation was found between the type of epithelium detected and the location of the TDC at the time of diagnosis.

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Clinicopathological studies on thyroglossal duct remnant

Cited by 4 publications

References 4 publications

A Clinicopathologic Series of 685 Thyroglossal Duct Remnant Cysts

A Clinicopathologic Series of 685 Thyroglossal Duct Remnant Cysts

Our Surgery Experience with Thyroglossal Ductus Cyst and Fistules

The Relationship Between the Location of Thyroglossal Duct Cysts and the Epithelial Lining

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