Clinicopathological Studies of Esophageal Carcinosarcoma: Analyses of its Morphological Characteristics Using Endoscopic, Histological, and Immunohistochemical Procedures

Chino, Osamu; Kijima, Hiroshi; Sasaki, Hideo; Nishi, Takayuki; Tanaka, Hideo; Oshiba, G; Kise, Yoshifumi; Kenmochi, Takahiro; Himeno, Hiromi; Tsuchida, Toru; Kawai, Kenji; Tanaka, Motomu; Machimura, Takao; Tajima, Takayuki; Makuuchi, Hiroyasu

doi:10.1055/s-2000-9026

Cited by 50 publications

(77 citation statements)

References 12 publications

(17 reference statements)

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“…Chino et al 77 also observed increased expression of p53 protein both in carcinoma associated with idiopathic achalasia and in dysplasia, suggesting that dysplastic alterations in patients with advanced achalasia may be related to increased risk of tumor development. These authors also detected loss of p16 protein expression, which together with p53 participates in cell cycle regulation in the invasive parts of the carcinoma and in situ carcinoma in relation to the areas with dysplasia, hyperplasia, and normal epithelium.…”

Section: Chagas Disease Megaesophagus and Its Association With Esophamentioning

confidence: 94%

Implications of genetic variability of Trypanosoma cruzi for the pathogenesis of Chagas disease

Manoel-Caetano

Silva

2007

Cad. Saúde Pública

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Section: Chagas Disease Megaesophagus and Its Association With Esophamentioning

confidence: 94%

Implications of genetic variability of Trypanosoma cruzi for the pathogenesis of Chagas disease

Manoel-Caetano

Silva

2007

Cad. Saúde Pública

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“…The various terms in use reflect the uncertain pathogenesis of this tumor. 9 Chino et al 10 reported that the carcinomatous component was differentiated squamous cell carcinoma and the sarcomatous component was spindle cell carcinoma. Histological cell (so-called carcinosarcoma), in other words, the sarcomatous components are considered to result from metaplasia of carcinoma cells.…”

Section: Discussionmentioning

confidence: 99%

A Case of Metachronous Development of Esophageal Squamous Cell Carcinoma in the Patient with Esophageal Carcinosarcoma

R.i.

Jung

et al. 2014

Korean J Gastroenterol

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Esophageal carcinosarcoma is a rare malignant esophageal neoplasm consisting of both carcinomatous and sarcomatous elements, with an incidence of 0.5%. There have been only a few case reports of carcinosarcoma and squamous cell carcinoma coexisting in the esophagus. However, all of these are cases of synchronous or metachronous development of carcinosarcoma after chemoradiotherapy in patients of esophageal squamous cell carcinoma. A 53-year-old man underwent esophagogastroduodenoscopy because of chest pain for several months. Endoscopic examination revealed a huge pedunculated esophageal polypoid mass. Endoscopic submucosal dissection (ESD) was performed and histopathologic examination confirmed spindle cell carcinoma (carcinosarcoma). He refused additional esophagectomy. After 21 months, third follow-up endoscopy showed poorly-demarcated flat, faint discolored lesions at different location from the previous ESD site and endoscopic biopsies confirmed squamous cell carcinoma. To the best of our knowledge, this is the first case of metachronous development of esophageal squamous cell carcinoma in a patient with esophageal carcinosarcoma. (Korean J Gastroenterol 2014;64:364-369)

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“…The incidence of carcinoma in patients with achalasia has been reported to range from 1.5% to 3.7% [5][6][7][8], and some studies have shown that, on average, patients with achalasia at the time of the diagnosis of carcinoma were in their fifties, i.e., earlier than patients with a normal esophagus [9,10]. Chino et al reported that most cases of esophageal carcinoma associated with achalasia had advanced achalasia with a flask-or sigmoid-type and grade II or III esophageal dilatation on X-ray classification by an esophagogram [9].…”

Section: Discussionmentioning

confidence: 98%

A case of multiple esophageal carcinomas concomitant with achalasia

Makino

Kawachi²

2006

Esophagus

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A 51-year-old man had been diagnosed with esophageal achalasia 26 years previously; however, regular medical examination was not performed. He presented to the hospital for severe back pain and increased dysphagia during the past 7 months. Endoscopic examination showed the presence of multiple primary carcinoma of the esophagus with achalasia. An esophagogram showed sigmoid-type achalasia with grade III dilatation. Subtotal esophagectomy with mediastinal and abdominal lymphadenectomy was performed. Histopathological examination showed three squamous cell carcinomas at pStage IVB, including pT3 and pM1b. Furthermore, all the three lesions located in the large, slightly iodine-stained area showed hyperplasia with inflammatory cells. Although adjuvant chemotherapy was administered, the patient died of recurrence on the right chest wall and in the stomach, liver, and left iliac bone at 23 months after operation. A patient with esophageal achalasia should be carefully followed up by endoscopy with iodine staining.

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Clinicopathological Studies of Esophageal Carcinosarcoma: Analyses of its Morphological Characteristics Using Endoscopic, Histological, and Immunohistochemical Procedures

Abstract: It is conceivable that the carcinomatous and sarcomatous components grow separately from the early stage of the tumors, and that the sarcomatous component forms a protruding tumor mass because it has abundant stroma positive for type IV collagen and laminin.

Cited by 50 publications

References 12 publications

Implications of genetic variability of Trypanosoma cruzi for the pathogenesis of Chagas disease

Implications of genetic variability of Trypanosoma cruzi for the pathogenesis of Chagas disease

A Case of Metachronous Development of Esophageal Squamous Cell Carcinoma in the Patient with Esophageal Carcinosarcoma

A case of multiple esophageal carcinomas concomitant with achalasia

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