Clinicopathological Significance of Nerves in Esophageal Cancer

Griffin, Nathan; Rowe, Christopher W; Gao, Fangfang; Jobling, Phillip; Wills, Vanessa; Walker, Marjorie M.; Faulkner, Sam; Hondermarck, Hubert

doi:10.1016/j.ajpath.2020.05.012

Cited by 14 publications

(20 citation statements)

References 41 publications

(41 reference statements)

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“…17 Esophageal tumors with higher NGF expression were infiltrated by nerves more often than low NGF-expressing counterparts. 28 These results suggest that nerve infiltration could be triggered by tumor-derived NGF. In contrast, semaphorins, a large family of extracellular signaling proteins, modulate axonal guidance.…”

Section: Axonogenesismentioning

confidence: 85%

“…Likewise, brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), that are upregulated in cancer cells, increase nerve density through axonogenesis in pancreatic ductal adenocarcinoma 18 and in gastric cancer 17 . Esophageal tumors with higher NGF expression were infiltrated by nerves more often than low NGF-expressing counterparts 28 . These results suggest that nerve infiltration could be triggered by tumor-derived NGF.…”

Section: Axonogenesismentioning

confidence: 97%

“…Esophageal cancers and normal esophageal tissues have nerve infiltration by both nerve fibers and nerve trunks, detected by PGP9.5 immunostaining 28 . Taking the presence or absence of nerves in TMAs as a dichotomous variable, 96% of normal samples had nerves, 40% of squamous type cancers, and 18% of adenocarcinomas were infiltrated by nerves.…”

Section: Gastric Esophageal and Colorectal Cancersmentioning

confidence: 99%

“…While there was no association between presence of nerves and clinical outcome variables, presence of PNI was significantly associated with poor survival (n = 9 PNI-positive patients). However, no measurement of nerve density was performed, likely due to the limitations of using TMA tissue 28 .…”

Section: Gastric Esophageal and Colorectal Cancersmentioning

confidence: 99%

“…Esophageal cancers and normal esophageal tissues have nerve infiltration by both nerve fibers and nerve trunks, detected by PGP9.5 immunostaining. 28 Taking the presence or absence of nerves in TMAs as a dichotomous variable, 96% of normal samples had nerves, 40% of squamous type cancers, and 18% of adenocarcinomas were infiltrated by nerves. While there was no association between the presence of nerves and clinical outcome variables, the presence of PNI was significantly associated with poor survival (n = 9 PNI-positive patients).…”

Section: Gastric Esophageal and Colorectal Cancersmentioning

confidence: 99%

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Nerve density in cancer: Less is better

2021

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The density of nerves in cancer is emerging as a relevant clinical parameter for patient survival.Nerves in the tumor microenvironment have been associated with poor survival and recurrence, particularly if involved in perineural invasion. However, usually only a few nerves inside a tumor are affected by perineural invasion, while most nerves are not. Mechanistic studies have shown nervesecreted factors promote tumor growth and invasion thereby making tumors more aggressive.Therefore, the overall number of nerves in the tumor microenvironment should be more representative of the nerve-tumor biological interaction than perineural invasion. This literature review summarizes the available clinical information about nerve density as a measure of clinical outcome in cancer and explores the mechanisms underlying nerve density in cancer, specifically, neurogenesis, axonogenesis, and neurotropism.

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Section: Axonogenesismentioning

confidence: 85%

Section: Axonogenesismentioning

confidence: 97%

Section: Gastric Esophageal and Colorectal Cancersmentioning

confidence: 99%

Section: Gastric Esophageal and Colorectal Cancersmentioning

confidence: 99%

Section: Gastric Esophageal and Colorectal Cancersmentioning

confidence: 99%

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