Clinicopathological significance of ganglioside DSGb5 expression in renal cell carcinoma

Itoh, Jun; Ito, Akihiro; Shimada, Shuichi; Kawasaki, Yoshihide; Kakoi, Narihiko; Saitō, Hideo; Mitsuzuka, Koji; Watanabe, Mika; Satoh, Makoto; Saito, Seiichi; Arai, Yoichi

doi:10.1007/s10719-017-9763-x

Cited by 8 publications

(8 citation statements)

References 17 publications

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“…Disialosyl globopentaosylceramide (DSGb5), is a ganglioside originally isolated from tissue extracts of RCC, and higher expression of DSGb5 is associated with lower recurrence-free survival in RCC 34 . DSGb5 expressed on RCC cells binding to sialic acid-binding lg-like lectin 7 (Siglec-7) on NK cells, which leads to inhibition of NK cell cytotoxicity 35 .…”

Section: (Iii) Tumor-associated Gangliosidesmentioning

confidence: 99%

Immune evasion in renal cell carcinoma: biology, clinical translation, future directions

Wang

Lopez

Luchtel

et al. 2021

Kidney International

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: (Iii) Tumor-associated Gangliosidesmentioning

confidence: 99%

Immune evasion in renal cell carcinoma: biology, clinical translation, future directions

Wang

Lopez

Luchtel

et al. 2021

Kidney International

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“…Disialosyl globopentaosylceramide (DSGb5) is a dominant ganglioside isolated from RCC tissues [ 70 ] which binds to sialic acid-binding Ig-like lectin-7 (Siglec-7) expressed on natural killer (NK) cells, thereby inhibiting NK-cell cytotoxicity [ 71 ]. Higher DSGb5 expression exhibits greater migration potential in ACHN RCC cells and is correlated with metastasis in RCC patients [ 71 , 72 ]. Other gangliosides, such as GalNAc disialosyl lactotetraosylceramide [ 73 ] and monosialosyl galactosylgloboside (MSGG) [ 74 , 75 ], bring a higher risk of metastasis; however, the exact mechanisms are still not thoroughly investigated.…”

Section: Glycosphingolipids In Renal Cancermentioning

confidence: 99%

Lipids as Targets for Renal Cell Carcinoma Therapy

Tanturovska

Manaila

Fabbro³

et al. 2023

IJMS

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Kidney cancer is among the top ten most common cancers to date. Within the kidney, renal cell carcinoma (RCC) is the most common solid lesion occurring. While various risk factors are suspected, including unhealthy lifestyle, age, and ethnicity, genetic mutations seem to be a key risk factor. In particular, mutations in the von Hippel–Lindau gene (Vhl) have attracted a lot of interest since this gene regulates the hypoxia inducible transcription factors HIF-1α and HIF-2α, which in turn drive the transcription of many genes that are important for renal cancer growth and progression, including genes involved in lipid metabolism and signaling. Recent data suggest that HIF-1/2 are themselves regulated by bioactive lipids which make the connection between lipids and renal cancer obvious. This review will summarize the effects and contributions of the different classes of bioactive lipids, including sphingolipids, glycosphingolipids, eicosanoids, free fatty acids, cannabinoids, and cholesterol to renal carcinoma progression. Novel pharmacological strategies interfering with lipid signaling to treat renal cancer will be highlighted.

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“…Primary RCC with expression of MSGb5 or GalNAcDSLc4 had a high risk of metastasis based on immunostaining in fresh-frozen sections of RCC tissue (Saito et al 1997;Maruyama et al 2007). DSGb5 expression was associated with microvascular invasion in paraffinembedded RCC tissues, and patients with high DSGb5 expression showed significantly lower recurrence-free survival rates (Itoh et al 2017). From the results of in vitro experiments using small interfering RNA (siRNA) transfectant for DSGb5 synthase gene, it was found that DSGb5 expressed in RCC cells inhibits the cytotoxicity of natural killer (NK) cells through interactions between sialic acidbinding immunoglobulin-like lectin-7 (Siglec-7) on NK cells and DSGb5 on RCC cells (Ito et al 2001a;Kawasaki et al 2010).…”

Section: Introductionmentioning

confidence: 95%

Expression of Ganglioside Disialosyl Globopentaosyl Ceramide in Prostate Biopsy Specimens as a Predictive Marker for Recurrence after Radical Prostatectomy

Sato

Shimada

Watanabe

et al. 2020

Tohoku J. Exp. Med.

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Carbohydrate antigens are associated with carcinogenesis, cancer invasion, and metastasis and their expression reflect biological activities of various cancers. We previously reported that expression of disialosyl globopentaosyl ceramide (DSGb5), one of carbohydrate antigens, in radical prostatectomy specimens independently predicted biochemical recurrence (i.e., elevating serum prostate specific antigen without recurrent lesions in the image) after radical prostatectomy. However, it is important to evaluate the prognosis at the diagnosis. In this study we investigated DSGb5 expression in prostate biopsy specimens to develop a novel biomarker for providing appropriate management. Between 2005 and 2011, patients who underwent both prostate biopsy and radical prostatectomy in our institution were included. The median follow-up period was 88 months. DSGb5 expression was assessed by immunohistochemical staining and defined 116 patients as high DSGb5 expression (42 patients) or low DSGb5 expression (74 patients). High DSGb5 expression was significantly associated with lymphovascular invasion in radical prostatectomy specimens on both univariate and multivariable analyses (p = 0.028, 0.027). On multivariable analysis, Gleason Score in prostatectomy specimen, positive resection margin, and DSGb5 expression in the biopsy specimen were independently associated with biochemical recurrence-free survival following radical prostatectomy (p = 0.004, 0.008, 0.024). When targeting only patients with negative resection margin, DSGb5 expression was significantly associated with biochemical recurrencefree survival on both univariate and multivariable analyses (p = 0.006, 0.007). DSGb5 expression in prostate biopsy specimens is predictive of lymphovascular invasion and biochemical recurrence-free survival following radical prostatectomy. DSGb5 is a potential biomarker for preoperatively predicting oncological outcomes of prostate cancer.

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Clinicopathological significance of ganglioside DSGb5 expression in renal cell carcinoma

Cited by 8 publications

References 17 publications

Immune evasion in renal cell carcinoma: biology, clinical translation, future directions

Immune evasion in renal cell carcinoma: biology, clinical translation, future directions

Lipids as Targets for Renal Cell Carcinoma Therapy

Expression of Ganglioside Disialosyl Globopentaosyl Ceramide in Prostate Biopsy Specimens as a Predictive Marker for Recurrence after Radical Prostatectomy

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