Clinicopathological Significance and Predictive Value of High Intratumoral Tumor Budding in Patients With Breast Carcinoma Treated With Neoadjuvant Chemotherapy

Chu, Jinah; Kim, Hyunsoo; Im, Sung Il

doi:10.21873/anticanres.16397

Cited by 3 publications

(3 citation statements)

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“…Immunostaining for Ki-67 was performed using whole-tissue sections as described previously [16][17][18][19][20][21][22][23][24]. For each case, the most representative slide containing >80% of viable tumor tissue was chosen for immunostaining.…”

Section: Immunohistochemical Stainingmentioning

confidence: 99%

Endocervical Adenocarcinoma Showing Microcystic, Elongated, and Fragmented (MELF) Pattern of Stromal Invasion: A Single-Institutional Analysis of 10 Cases with Comprehensive Clinicopathological Analyses and Ki-67 Immunostaining

Bae,

Kim

2023

Biomedicines

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Microcystic, elongated, and fragmented (MELF) pattern of invasion has seldom been documented in endocervical adenocarcinoma (EAC). The aim of this study was to analyze the clinicopathological characteristics of EAC showing MELF pattern. We collected the clinicopathological information of 10 cases of EAC with the MELF pattern and conducted polymer-based immunostaining for Ki-67 (dilution 1:200, clone MIB-1) on these cases. Ki-67 expression was assessed using the average estimation within the hotspot method. All tumors were human papillomavirus-associated EAC with Silva pattern C. All except one tumor exceeded 3 cm in size. Five tumors involved the entire thickness of the cervical stroma, and four tumors extended into the parametrium. Lymphovascular space invasion was identified in six cases. Two patients developed metastatic recurrences in the para-aortic lymph nodes and lungs, respectively. The MELF area showed significantly lower Ki-67 labelling index than that of a conventional tumor area. We confirmed our previous observation that the MELF area displayed lower proliferative activity than the conventional tumor area of EAC. We also demonstrated that patients with EAC showing MELF pattern had several adverse clinicopathological characteristics reflecting aggressive behavior. On the other hand, since the frequencies of post-operative recurrence and disease-related mortality that occurred during the follow-up period were relatively low, further investigations are warranted to clarify the prognostic value of MELF pattern in EAC patients.

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Section: Immunohistochemical Stainingmentioning

confidence: 99%

Endocervical Adenocarcinoma Showing Microcystic, Elongated, and Fragmented (MELF) Pattern of Stromal Invasion: A Single-Institutional Analysis of 10 Cases with Comprehensive Clinicopathological Analyses and Ki-67 Immunostaining

Bae,

Kim

2023

Biomedicines

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“…Immunohistochemistry. Immunostaining was performed using Bond-III immunostainer (Leica Biosystems, Newcastle-upon-Tyne, UK) (12)(13)(14)(15)(16)(17)(18)(19)). An antigen retrieval was performed using Bond ER2 Solution (Leica Biosystems) for 30 min at 100˚C.…”

Section: Clinicopathological Data Collectionmentioning

confidence: 99%

Gastrointestinal Follicular Lymphoma: A Single-institutional Experience of 22 Cases With Emphasis on the Comprehensive Clinicopathological Analysis and Diagnostic Re-classification

OH,

KIM,

et al. 2023

Anticancer Res

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Background/Aim: Distinguishing gastrointestinal involvement in classic follicular lymphoma (CFL) and duodenal-type follicular lymphoma (DFL) is crucial for proper treatment. This study aimed to describe an integrated diagnostic re-classification of gastrointestinal follicular lymphoma (GIFL) and identify useful features for its differential diagnosis. Patients and Methods: We reviewed radiological and endoscopic images and pathology slides of 22 GIFL cases, not otherwise specified. Results: Thirteen cases of duodenal grade 1 FL without nodal disease were reclassified as DFL. Five cases of non-duodenal grade 3 FL accompanied by nodal enlargement were re-classified as CFL. The DFL showed peripherally accentuated CD21 immunoreactivity, whereas the CFL showed strong homogeneous CD21 expression. Four atypical cases were reclassified as DFL and CFL in one and three cases, respectively. Conclusion: Our findings support the notion that DFL differs from CFL. In cases of GIFL with atypical features, the possibility of gastrointestinal involvement by CFL should be considered. CD21 expression patterns can assist in the differential diagnosis of CFL and DFL.

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“…TB has already been investigated in many tumors (colon carcinoma, gastric cancer, urothelial carcinoma, pancreatic carcinoma, breast cancer, endometrial carcinoma, lung cancer, esophageal cancer, liver cancer) [4][5][6][7][8][9][10][11][12]. In many tumors, the TB score is associated with a worse prognosis [13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

New Tumor Budding Evaluation in Head and Neck Squamous Cell Carcinomas

Cacchi,

Fischer,

Wermker

et al. 2024

Cancers

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Background: Tumor budding (TB) is a histomorphological characteristic of the tumor invasion front and it has an impact on the tumor outcome prediction for head and neck squamous cell carcinoma (HNSCC) aetiopathology. Patients and methods: The average TB score (TB rel) of all tumor-positive marginal sections (n = 443) in the primary tumor was analyzed in the FFPE-fixed tumor slices of 66 patients with HNSCC, and they were compared with cryo-fixed sections. Results: TB rel correlates with tumor aggressiveness (i.e., lymph node metastasis quantity, lymph node ratio, extra capsular growth, Pn1, pV1, grading). The TB scores often vary between the different tumor margins of FFPE sections in the same patient, and in many cases, they differ depending on the fixation method. Conclusion: Our data show that a randomly selected marginal cut cannot reliably mirror the TB score, and thus, they cannot predict the prognostic outcome. However, TB rel could be a tool that compensates for differences in TB score analysis. TB score determination in cryo sections seems to be inaccurate compared with TB determination in FFPE.

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Clinicopathological Significance and Predictive Value of High Intratumoral Tumor Budding in Patients With Breast Carcinoma Treated With Neoadjuvant Chemotherapy

Cited by 3 publications

References 0 publications

Endocervical Adenocarcinoma Showing Microcystic, Elongated, and Fragmented (MELF) Pattern of Stromal Invasion: A Single-Institutional Analysis of 10 Cases with Comprehensive Clinicopathological Analyses and Ki-67 Immunostaining

Endocervical Adenocarcinoma Showing Microcystic, Elongated, and Fragmented (MELF) Pattern of Stromal Invasion: A Single-Institutional Analysis of 10 Cases with Comprehensive Clinicopathological Analyses and Ki-67 Immunostaining

Gastrointestinal Follicular Lymphoma: A Single-institutional Experience of 22 Cases With Emphasis on the Comprehensive Clinicopathological Analysis and Diagnostic Re-classification

New Tumor Budding Evaluation in Head and Neck Squamous Cell Carcinomas

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