Clinicopathological profile of lung cancer at a tertiary care center

Dattatreya, Satya; Bansal, Rekha; Vamsy, Mohana; Vaniawala, Salil; Nirni, Sharanabasappa Somanath; Dayal, Monal; Sharma, Rakesh Kumar

doi:10.4103/ijc.ijc_455_17

Cited by 5 publications

(5 citation statements)

References 13 publications

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“…The most common sign in patients with lung cancer in the present study was clubbing, as reported by other authors. 13,19 The commonest radiological presentation in the present study was mass lesion which is consistent with previous studies. 14,19 This was followed by pleural effusion (51%).…”

Section: Discussionsupporting

confidence: 92%

“…13,19 The commonest radiological presentation in the present study was mass lesion which is consistent with previous studies. 14,19 This was followed by pleural effusion (51%). A higher incidence of pleural effusion as compared to previous studies 6,14 may be due to a higher proportion of patients presented in advanced stage with higher prevalence of ADC lung, which is more frequently associated with pleural effusion as compared to SCC and SCLC.…”

Section: Discussionsupporting

confidence: 92%

“…The incidence of atelectasis and pericardial effusion was similar to that found in previous Indian studies. 18,19 We found that upper lobes were involved more frequently than lower lobes which may be attributable to a higher exposure of upper lobes to tobacco smoke and air pollutants. SVC obstruction was significantly higher in patients of SCLC.…”

Section: Discussionmentioning

confidence: 72%

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Clinico-pathological Profile of Lung Cancer Patients in a Tertiary Care Hospital, India: A Prospective, Cross-sectional Study

Sen¹,

Bhattacharya²,

Suri³

et al. 2022

The Indian Journal of Chest Diseases and Allied Sciences

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Background: Adenocarcinoma (ADC) is the commonest subtype of lung cancer, though a number of studies in India have observed squamous cell carcinoma (SCC) to be the commonest histology. Majority of Indian studies on clinico-pathological profile are retrospective and there is limited data on comparison of demographic, clinical, and radiological features among histological subgroups of lung cancer. Methods: Three-hundred and twelve consecutive confirmed cases of lung cancer diagnosed from December 2014 to January 2017 were enrolled prospectively. Data pertaining to the demographic, clinical, radiological, pathological, and molecular profile were analyzed. Results: Their mean age was 57.2 ± 10.8 years. Of all the lung cancer patients studied, 80.5% were males and 73.4% were smokers. Across all histological subtypes, the commonest symptom was cough (76.9%). Chest pain, hoarseness of voice, dysphagia, and neck veins engorgement were significantly higher in small cell lung carcinoma (SCLC) cases, while hemoptysis in SCC cases. The most common radiological finding was a mass lesion predominantly located, peripherally in cases with ADC and SCC lung, while centrally in SCLC. The most common site for distant metastasis was the bone (32.5%), followed by the liver, adrenal, brain, and other organs. ADC, SCC, and SCLC constituted 48.1, 32.1, and 14.4%, respectively. Incidence of epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) mutations in ADC patients were 26.5% and 7.8%, respectively, with a predilection for nonsmokers. The most common EGFR mutation was exon 19 deletions. Conclusions: Adenocarcinoma lung may now be replacing SCC as the commonest type of lung cancer in Northern India. The overall incidence of EGFR mutations in ADC patients was 26.5%, with exon 19 deletion being the most common mutation.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 72%

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Clinico-pathological Profile of Lung Cancer Patients in a Tertiary Care Hospital, India: A Prospective, Cross-sectional Study

Sen¹,

Bhattacharya²,

Suri³

et al. 2022

The Indian Journal of Chest Diseases and Allied Sciences

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“…Adenocarcinoma was the most common histological subtype (66%). Squamous cell carcinoma was present in 11.6% patients [8] . Immunophenotypes of the various histological types of lung cancer are stable and highly reproducible in most cases, with TTF1 and CK7 showed positivity in the glandular differentiation of adenocarcinoma and CK5/6 and p63 the keratinizing differentiation of squamous cell carcinoma [11,12] .…”

Section: Inclusion Criteriamentioning

confidence: 98%

“…Another 20 cases (40%) were positive for CK 5/6 and p63 which were categorized under Squamous Cell Carcinoma (Figure 2) and Remaining 7 cases (14%) were positive for TTF, Synaptophysin and Chromogranin which were categorized under Small Cell Carcinoma (Figure 3). [8] . In our study, out of 50 patients, 48 were males (96%) and 2(4%) were females.…”

Section: Inclusion Criteriamentioning

confidence: 99%

Role of histopathological and immunohistochemical technique in diagnosis of lung carcinoma

Thakor¹,

Bed²,

Bhetariya³

2022

Int. J. Clin. Diagn. Pathol.

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Background: Lung cancer is currently the most frequently diagnosed major cancer and the most common cause of cancer mortality worldwide. M ost lung cancers are associated with a well-known Carcinogen i.e., Cigarette Smoking. Immunohistochemistry helps in the sub typing of the lung neoplasm into different categories which have a therapeutic and prognostic importance. Materials and Methods:The present study is both retrospective and prospective study done at Pathology Department over a period of 1 year (October 2021 to September 2022). The present study was carried out on 50 patients presented with lung mass in radiological examination and undergone biopsy procedure and samples of the same were received at Histopathological section of Pathology Department, Shri M .P. Shah Govt. medical college, Jamnagar. Cases were diagnosed by histopathological examination and subtyping were done by Immunohistochemistry. Aims and Objectives To determine the incidence of lung carcinoma with respect to age and sex of patients. To correlate between incidence and associated risk factors for lung carcinoma like smoking. To use Immunohistochemistry for subtyping of lung carcinoma. Results: In present study, out of 50 cases, most common histological type of lung carcinoma was Adenocarcinoma (n=23 cases,46%) followed by Squamous cell Carcinoma (n=20 cases,40%) and Small Cell Carcinoma (n=7 cases, 14%). There was male preponderance (96%) and male to female ratio was 25:1. Right sided Lung was most commonly involved (60%) than Left sided Lung (40%). Conclusion:As subtyping is important for different treatment modalities, the present study highlights the importance of histopathological and immunohistochemical study in diagnosis and subtyping of lung carcinoma. In this study we found that adenocarcinoma was most common subtype of lung carcinoma in Saurashtra region than other subtypes and majority of them were smokers.

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Rare compound mutation of EGFR L858R and E709A identified in both solid tumor and liquid biopsy of a lung adenocarcinoma patient

Jha,

Trivedi,

Shah

et al. 2024

Medical Reports

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Clinicopathological profile of lung cancer at a tertiary care center

Cited by 5 publications

References 13 publications

Clinico-pathological Profile of Lung Cancer Patients in a Tertiary Care Hospital, India: A Prospective, Cross-sectional Study

Clinico-pathological Profile of Lung Cancer Patients in a Tertiary Care Hospital, India: A Prospective, Cross-sectional Study

Role of histopathological and immunohistochemical technique in diagnosis of lung carcinoma

Rare compound mutation of EGFR L858R and E709A identified in both solid tumor and liquid biopsy of a lung adenocarcinoma patient

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