Clinicopathological Profile of 80 Cases of Unicystic Ameloblastoma Aided by a Histopathological Comparison Using Modified Philipsen–Reichart Classification and Marx–Stern Classification

Narwal, Anjali; Pandiar, Deepak; Kamboj, Mala; Devi, Anju; Saxena, Shikha; Sundaragiri, Krishna Sireesha; Wadhwan, Vijay; Reddy, Vandana; George, Jiji

doi:10.1007/s12105-021-01307-7

Cited by 2 publications

(6 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…9,10 UA accounts for 5 to 22% of ameloblastomas, most commonly involving the mandible (about 89%). 5-7…”

Section: Odontogenic Tumorsmentioning

confidence: 99%

“…The tumor must be confined to the cystic lumen and/or wall, as extension into the adjacent bone precludes classification of the tumor under the unicystic category. 7…”

Section: Odontogenic Tumorsmentioning

confidence: 99%

“…3,4 UA presents in younger populations than solid multicystic ameloblastoma, with a mean age of 22.8 (range of 10 months to 88 years), median age 30 years, and a slight male predilection. [5][6][7][8] The average age of UA associated with an impacted tooth is younger than those not associated with an impacted tooth (in 1 study 16.5 versus 35.2 years), and its clinical presentation can mimic a dentigerous cyst. 9,10 UA accounts for 5 to 22% of ameloblastomas, most commonly involving the mandible (about 89%).…”

Section: Odontogenic Tumorsmentioning

confidence: 99%

“…9,10 UA accounts for 5 to 22% of ameloblastomas, most commonly involving the mandible (about 89%). [5][6][7] Gross Features. UA is defined as a single cystic cavity, with or without luminal proliferation.…”

Section: Odontogenic Tumorsmentioning

confidence: 99%

See 3 more Smart Citations

Pediatric Odontogenic Tumors

Liu,

Smith,

Patel

et al. 2023

Pediatr Dev Pathol

View full text Add to dashboard Cite

Odontogenic tumors are rare tumors of the jaws that arise from remnants of the tooth forming apparatus. Some odontogenic tumors demonstrate strong predilection for pediatric patients including the unicystic ameloblastoma, adenomatoid odontogenic tumor, ameloblastic fibroma, ameloblastic fibro-odontoma, odontoma, and primordial odontogenic tumor. In this review, we discuss the clinical, radiographic, histopathologic, and molecular characteristics of select odontogenic tumors that demonstrate pediatric predilection and review management.

show abstract

“…9,10 UA accounts for 5 to 22% of ameloblastomas, most commonly involving the mandible (about 89%). 5-7…”

Section: Odontogenic Tumorsmentioning

confidence: 99%

“…The tumor must be confined to the cystic lumen and/or wall, as extension into the adjacent bone precludes classification of the tumor under the unicystic category. 7…”

Section: Odontogenic Tumorsmentioning

confidence: 99%

Section: Odontogenic Tumorsmentioning

confidence: 99%

Section: Odontogenic Tumorsmentioning

confidence: 99%

See 2 more Smart Citations

Pediatric Odontogenic Tumors

Liu,

Smith,

Patel

et al. 2023

Pediatr Dev Pathol

View full text Add to dashboard Cite

show abstract

“…It mainly comprises follicular and plexiform histological patterns, and less commonly acanthomatous, granular cell, clear cell, and desmoplastic patterns, without any histological impact on tumor prognoses (8,9) . Unlike conventional ABs, the unicystic type is characterized by the following: a) tumor growth limited to the lumen with a very thin cystic lining and displays of only three varieties: luminal, intraluminal, and mural (otherwise it shares all of the classic histopathologic features of an AB), b) it has a unilocular radiolucent pattern, and c) it is considered less aggressive and less invasive; hence it responds effectively when treated with a conservative approach (10) .…”

Section: Introductionmentioning

confidence: 99%

Double Immunohistochemical Analysis of PCNA and FAK Expression in Selected Odontogenic Lesions

Baz

Mohamed

2023

Egyptian Dental Journal

View full text Add to dashboard Cite

Background: Odontogenic neoplasms and cysts have diverse biological behaviors, ranging from indolence to aggression along a spectrum. The proliferating cell nuclear antigen (PCNA) is an antigen involved in DNA synthesis and proliferation. Focal adhesion kinase (FAK) is a cytoplasmic molecule associated with cellular signaling, growth, and invasion. PCNA and FAK markers have been shown to be involved in neoplastic proliferation, invasion, and migration. Hence, an immunohistochemical assay of PCNA and FAK can be used as a predictive tool for the level of aggressive behavior of odontogenic lesions. Methods:The current study was conducted to evaluate the expressions of PCNA and FAK. A double immunohistochemical technique for conventional ameloblastoma (AB), unicystic AB, calcifying epithelial odontogenic tumor (CEOT), and glandular odontogenic cyst (GOC) was used to evaluate the role of both markers in assessments of the aggressiveness of selected odontogenic lesions. All formalin-fixed paraffin-embedded blocks (n = 10) for each studied group were double PCNA and FAK immunostained and then assessed using a transmission light microscope and an image-analyzer computer system. Statistical analysis was performed with a one-way analysis of variance (ANOVA) test followed by Tukey's post hoc test.Results: All study groups showed nuclear immunoreactivity of PCNA and cytoplasmic immunoreactivity for FAK. The greatest mean nuclear count of PCNA and the greatest mean area percent for FAK were both recorded in the aggressive lesions; i.e., the CEOT group and conventional AB group. The non-aggressive unicystic AB group had a lower mean nuclear count for PCNA and showed the lowest mean area percent for FAK. Conclusions:In conclusion, PCNA and FAK immunoexpression profiles may have a strong correlation with the aggressive nature of AB, CEOT, and GOC. Hence, PCNA and FAK markers could aid in their routine examination, treatment planning, and prognosis.

show abstract

Clinicopathological Profile of 80 Cases of Unicystic Ameloblastoma Aided by a Histopathological Comparison Using Modified Philipsen–Reichart Classification and Marx–Stern Classification

Cited by 2 publications

References 21 publications

Pediatric Odontogenic Tumors

Pediatric Odontogenic Tumors

Double Immunohistochemical Analysis of PCNA and FAK Expression in Selected Odontogenic Lesions

Contact Info

Product

Resources

About