Clinicopathological Perspectives on Endometrioid Epithelial Ovarian Carcinoma in Indian Women

Abstract

Purpose To analyse cases of endometrioid epithelial ovarian carcinoma with respect to clinicopathological features, management and outcome at a tertiary cancer referral hospital in western India. disease, adjuvant therapy and survival were studied and analysed, using SPSS 22.0 software. Non-parametric tests for statistical significance and Kaplan-Meier survival analysis were applied. Results Out of 46 women (median age 50 years), 39 % were diagnosed in early stage, 24 % in advanced stage and 37 % were unstaged. Overall survival at 24 months was 87.8 %. It was associated with infertility (28 %), endometriosis (9 %) and synchronous endometrial carcinoma (20 %). R0 resection was achieved in 74 % of patients. Conclusions The univariate analysis showed that size of tumour, disease stage and R0 resection status were significant prognostic factors for endometrioid subtype of epithelial ovarian cancer. Endometrioid epithelial ovarian cancer was associated with synchronous endometrial carcinoma, nulliparity and younger age at presentation. NACT with interval cytoreduction (in patients with clinically advanced tumours where R0 resection may be unfeasible) can offer survival benefits equivalent to primary cytoreduction (in advanced stage).