Clinicopathological pattern and <i>HER 2/neu</i> status in patients presenting with different histological grades of colorectal carcinomas

Anwar, Sadia; Nagi, A. H.; Naseem, Nadia; Saqib, Muhammad; Sami, Waqas

doi:10.1111/j.1755-9294.2009.01069.x

Cited by 3 publications

(4 citation statements)

References 24 publications

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“…In the present study, we found a significant association between pattern of Her-2/ neu staining & grade of colorectal cancer which is in accordance with one of the study done in the same region but to note here is that they compared the significance of Her-2/ neu expression in different grades amongst different types of gastrointestinal carcinomas (gastric, small intestine and colorectal carcinomas) and did not primarily correlate the Her-2/ neu expression within different grades of colorectal carcinoma. Similarly, the other study done in our area reported a significant membranous Her-2/ neu expression in low grade colorectal carcinoma [13]. On contrary to this we noted membranous Her-2/ neu expression to be significantly associated with high grade colorectal cancer.…”

Section: Discussioncontrasting

confidence: 51%

“…In our series we found 26.6 % positivity for membranous Her-2/ neu staining. On contrary to this, two studies from the same region observed higher percentage of membranous expression of Her-2/ neu in colorectal carcinomas, 74.1 % ( n = 31) and 42 % ( n = 100) respectively [13, 22, 23]. The reason for the difference in the rate might be due to different scoring protocols where they took into account only the membranous expression of Her-2 /neu staining and did not consider the cytoplasmic expression.…”

Section: Discussionmentioning

confidence: 93%

“…Moreover, a very few studies have been published from this region regarding Her-2 /neu expression in colorectal adenocarcinoma [13–15]. Therefore, in this study we attempted to know the expression of Her-2/ neu in colorectal tumors in our population which might prove in future a useful prognostic factor and worthy therapeutic target for colorectal carcinoma.…”

Section: Introductionmentioning

confidence: 99%

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Frequency of Her2/neu expression in colorectal adenocarcinoma: a study from developing South Asian Country

et al. 2016

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BackgroundHuman Epidermal Growth Factor (Her-2/neu) has strong therapeutic implications in certain cancers like breast and gastric cancer. Literature on its frequency in colorectal cancer is scarce. In this study, we have investigated the frequency of Her-2/neu expression in colorectal adenocarcinomas and its association with various clinicopathological variables.MethodsA total of 95 patients who underwent colonoscopic biopsy or colectomy were studied after Institutional Ethical Approval. Hematoxylin & eosin (H&E) staining was performed on all the tissue sections. Expression of Her-2/neu was investigated by immunohistochemistry using α-Her-2 antibody. In order to quantify Her-2/neu expression, three criterias were applied that includes the pattern of staining, intensity of staining and percentage of tumor cells stained. Furthermore, its association was seen with various clinicopathological variables including age, gender, histopathological type, grade and stage of the tumor. Data was entered and analyzed using SPSS version 21. A p-value of < 0.05 was considered as significant.ResultsFrom the total of 95 cases, 75 (78.9 %) cases showed Her-2/neu expression. Pattern of Her-2/neu staining was significantly associated with the grade of colorectal cancer depicting cytoplasmic Her-2/neu expression higher in low grade (50 %) while membranous Her-2/neu expression more in high grade colorectal cancer (45 %) (P-value = 0.030). Pattern of Her-2/neu staining was also significantly associated with the type of colorectal cancer representing membranous Her-2/neu expression to be more common in mucinous type (38.5 %) while cytoplasmic Her-2/neu expression to be more frequent in non mucinous type (42.7 %) of colorectal cancer (p-value = 0.024).We observed a significant association between percentage of cells stained & tumor type, with score 3+ maximum in non mucinous type of colorectal cancer (p-value = 0.006).ConclusionHer2/neu is considerably expressed in colorectal adenocarcinoma in Pakistani population. Our findings indicate a significant strong association of cytoplasmic Her-2/neu expression with low grades and membranous Her-2/neu expression with high grades of colorectal cancer. These findings add to the body of information & may help in conducting clinical trials in future to explore its therapeutic significance as well.

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Section: Discussioncontrasting

confidence: 51%

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

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Frequency of Her2/neu expression in colorectal adenocarcinoma: a study from developing South Asian Country

et al. 2016

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“…Moreover, a very few studies have been published from this region regarding Her-2/neu expression in colorectal adenocarcinoma [13][14][15]. Therefore, in this study we attempted to know the expression of Her-2/neu in colorectal tumors in our population which might prove in future a useful prognostic factor and worthy therapeutic target for colorectal carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Frequency of Her2/neu expression in colorectal adenocarcinoma: A study from developing South Asian country

Shabbir¹,

Mirza²,

Khalid³

et al. 2016

J Gastrointest Dig Syst

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Background: Human Epidermal Growth Factor (Her-2/neu) has strong therapeutic implications in certain cancers like breast and gastric cancer. Literature on its frequency in colorectal cancer is scarce. In this study, we have investigated the frequency of Her-2/neu expression in colorectal adenocarcinomas and its association with various clinicopathological variables. Methods: A total of 95 patients who underwent colonoscopic biopsy or colectomy were studied after Institutional Ethical Approval. Hematoxylin & eosin (H&E) staining was performed on all the tissue sections. Expression of Her-2/ neu was investigated by immunohistochemistry using α-Her-2 antibody. In order to quantify Her-2/neu expression, three criterias were applied that includes the pattern of staining, intensity of staining and percentage of tumor cells stained. Furthermore, its association was seen with various clinicopathological variables including age, gender, histopathological type, grade and stage of the tumor. Data was entered and analyzed using SPSS version 21. A pvalue of < 0.05 was considered as significant. Results: From the total of 95 cases, 75 (78.9 %) cases showed Her-2/neu expression. Pattern of Her-2/neu staining was significantly associated with the grade of colorectal cancer depicting cytoplasmic Her-2/neu expression higher in low grade (50 %) while membranous Her-2/neu expression more in high grade colorectal cancer (45 %) (P-value = 0.030). Pattern of Her-2/neu staining was also significantly associated with the type of colorectal cancer representing membranous Her-2/neu expression to be more common in mucinous type (38.5 %) while cytoplasmic Her-2/neu expression to be more frequent in non mucinous type (42.7 %) of colorectal cancer (p-value = 0.024). We observed a significant association between percentage of cells stained & tumor type, with score 3+ maximum in non mucinous type of colorectal cancer (p-value = 0.006). Conclusion: Her2/neu is considerably expressed in colorectal adenocarcinoma in Pakistani population. Our findings indicate a significant strong association of cytoplasmic Her-2/neu expression with low grades and membranous Her-2/ neu expression with high grades of colorectal cancer. These findings add to the body of information & may help in conducting clinical trials in future to explore its therapeutic significance as well.

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A Study of Histopathological Distribution in Colorectal Cancer

Singh¹,

Jat

Singh

et al. 2021

ijsr

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Despite of advances in surgical techniques and adjuvant chemotherapeutic regimens, colorectal cancer remains one of the major leading causes of deaths worldwide. Histopathology is an important factor in the treatment and prognosis of cancer. The purpose of this study was to describe the different histopathological pattern in colorectal cancer. 81 cases of colorectal carcinoma received in pathology department over a period of four years were included in the study. The surgical specimen and colonoscopic biopsies' gross features were noted and samples were stained with Haematoxylin and Eosin. Detailed microscopic examination of tumor with lymph node status was done followed by histological typing. Grading of the tumor, age and sex distribution of cases were also noted. The commonest histopathological nding was adenocarcinoma 75.32% followed by mucinous adenocarcinoma 9.88% and signet ring cell carcinoma 8.64%. Among 61 cases of adenocarcinoma most commonly moderately differentiated adenocarcinoma 60.66% was noted.

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Clinicopathological pattern and HER 2/neu status in patients presenting with different histological grades of colorectal carcinomas

Cited by 3 publications

References 24 publications

Frequency of Her2/neu expression in colorectal adenocarcinoma: a study from developing South Asian Country

Frequency of Her2/neu expression in colorectal adenocarcinoma: a study from developing South Asian Country

Frequency of Her2/neu expression in colorectal adenocarcinoma: A study from developing South Asian country

A Study of Histopathological Distribution in Colorectal Cancer

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