Clinicopathological importance of Papanicolaou smears for the diagnosis of premalignant and malignant lesions of the cervix

Bukhari, Mulazim Hussain; Saba, Kanwal; Qamar, Samina; Majeed, Mudassar; Niazi, Shahida; Naeem, Samina

doi:10.4103/0970-9371.93213

Cited by 43 publications

(41 citation statements)

References 14 publications

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“…8 The age of the patient ranged from 17 to 78 years in our study and the predominant population in the present study was between 20-45 years (84.7%). This finding was similar Cervical Pap smears [4][5][6]13 0.6% of pap smears were from patients below 20 years and similar result (0.7%) was seen in study done in Karnataka, India. 14 However in studies done in mid western part of Nepal and Bangladesh there were no cases below 20 years.…”

Section: Discussionsupporting

confidence: 75%

“…Studies done in Kathmandu, Pakistan and India revealed 0.3%, 1.8% and 1.2% cases of unsatisfactory smear respectively. 4,6,14 Few other studies showed that the incidence of unsatisfactory smear to be quite high (11.9%, 9.5%, 5.7% and 4.8%). 9,11,13,16 Negative for Intraepithelal Lesion or Malignancy was seen in 87.9% cases which correlates well with study done by Bamanikar et al in a tertiary hospital (88.93%).…”

Section: Discussionmentioning

confidence: 99%

“…Since its introduction there has been a dramatic reduction in the incidence and mortality of invasive cervical cancer worldwide. [4][5][6] The 2001 Bethesda system terminology reflects important 823 advances in biological understanding of cervical neoplasia and cervical screening technology and is most widely used system for describing pap smear result. [7][8][9] This study is done to evaluate the pattern of cervical pap smear cytology and find out the incidence of epithelial cell abnormalities.…”

Section: Introductionmentioning

confidence: 99%

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Cervical pap smear- A prospective study in a tertiary hospital

et al. 2015

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Background: Cervical cancer is a leading cause of mortality and morbidity among women worldwide and most common gynaecological cancer in developing countries. Papanicolaou smear is a simple and cost effective screening test for cervical cancer. The aim of this study is to evaluate and interpret the cervical pap smear cytology in a tertiary hospital. The interpretation and reporting of the pap smear is based on 2001 Bethesda system. Materials and methods:This is a prospective study conducted in a tertiary hospital, Nepal Medical College over a period of two and a half years (January 2013 to June 2015). All cervical pap smears received in the department of Pathology in the study period were included.Results: A total of 4160 cervical pap smears were reported in the study period. Majority of the cases were Negative for Intraepithelial lesion or malignancy (87.9%). Bacterial vaginosis, atrophy and reactive cellular changes associated with inflammation were seen in 5.3%, 2.4% and 1.5% cases respectively. Epithelial cell abnormalities (0.5%) include Atypical squamous cells of undetermined significance, Low grade squamous intraepithelial lesion and High grade intraepithelial lesion. 88% of Low grade squamous intraepithelial lesion was seen in reproductive age group (20-45 years). Conclusion:Cervical cancer is the most common gynaecological cancer in the developing countries. Pap smear is the simple and cost effective screening tool to detect pre invasive cervical epithelial lesions.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cervical pap smear- A prospective study in a tertiary hospital

et al. 2015

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“…The overall incidence of CIN on cytology was 7.75% reported by Bhojani KR et al (2011) 7 and 8.2% by Bukhari et al (201210). 8 Thus, our result is very similar to these results.…”

Section: Cervical Malignancysupporting

confidence: 82%

Menopause and Cervical Cancer- Descriptive Study of Presentation and Management in Tertiary Centre of Jharkhand, India

Kumari¹,

Neelam²,

Yadav³

2017

jemds

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BACKGROUNDCervical cancer is the most common genital cancer encountered in clinical practice in India. According to WHO there are 510,000 new cases every year with 80% occurring in developing nations, half of these cases end in death. 1 Cervical cancer accounts for 15% of all cancer in women. Menopause is a consequence of biological aging. Menopause itself do not cause cancer, but the risk of cancer increases as the women ages. Most studies on cervical cancer screening have focused on premenopausal women with little information provided on perimenopausal or postmenopausal women. However, these women remain at increased risk for cervical cancer given that there is a second peak in prevalence of high-risk HPV subtype in this oldest population.The aim of the study was to determine the presentation as well as management of cervical cancer in postmenopausal women in Jharkhand.

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“…Pap smear continues to be one of the most important screening procedures for carcinoma cervix, at least, in the developing world [13] . In developed world, large scale screening is done using one of the commercially available automated protocols viz, Pap Net, [5] BD Focal Point.…”

Section: Discussionmentioning

confidence: 99%

A Semi - Automated Morphometric Assessment of Nuclei in Pap Smears Using Imagej

Raghavan¹,

K²

2015

jemds

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BACKGROUND AND PURPOSE: Carcinoma of cervix is the fourth commonest malignancy in women. Its incidence is progressively falling due to the routine use of Pap smears to detect precancerous lesions. However, routine Pap smear examination is time consuming and, as it is based on descriptive morphological assessment, false positive or negative reports are likely to occur. Using morphometric techniques, several attempts have been made to improve the accuracy of reports. In the present study, we have used Image morphometric software and some of its plugins to create a macro to analyse large number of cells at a time. MATERIALS AND METHODS: Using Image and three of its plugins, namely, BEEPS, Kuwahara filter and Mexican Hat filter, we created a macro to morphometrically analyse normal, reactive and neoplastic Pap smears. We also compared the macro measurements with manual measurements. RESULTS AND CONCLUSIONS: Results obtained with macro showed strong positive correlation with manual measurement. Although the neoplastic nuclei were on an average larger than reactive/normal nuclei, there was considerable overlap. More than the enlargement, anisonucleosis (variability in the size) appeared to be a better indicator of neoplasia. The macro that we developed works rapidly and gives results comparable to manual measurements provided the smears and the photographs are technically acceptable.

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Clinicopathological importance of Papanicolaou smears for the diagnosis of premalignant and malignant lesions of the cervix

Cited by 43 publications

References 14 publications

Cervical pap smear- A prospective study in a tertiary hospital

Cervical pap smear- A prospective study in a tertiary hospital

Menopause and Cervical Cancer- Descriptive Study of Presentation and Management in Tertiary Centre of Jharkhand, India

A Semi - Automated Morphometric Assessment of Nuclei in Pap Smears Using Imagej

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