Clinicopathological findings in dogs with distemper encephalomyelitis presented without characteristic signs of the disease

Molecular detection and phylogenetic relationship of wild-type strains of canine distemper virus in symptomatic dogs from Uberlândia, Minas Gerais

“…Further, RT-PCR assays detected CDV viruria in these dogs, and sequencing revealed partial sequences of the CDV N gene from three urine samples. These findings confirmed the participation of CDV in the etiopathogenesis of the disease manifestations observed in these dogs; similar results have been described (Amude et al, 2007;Headley et al, 2013). Additionally, RT-PCR identified CDV viruria in an additional ten dogs with diverse clinical manifestations (neurological and nonneurological) that were attributed to CD, indicating that these other dogs were also infected by CDV.…”

“…Additionally, RT-PCR identified CDV viruria in an additional ten dogs with diverse clinical manifestations (neurological and nonneurological) that were attributed to CD, indicating that these other dogs were also infected by CDV. Similar results were observed in dogs with neurological manifestations suggestive of CDV but with molecular confirmation in some of the affected dogs (Amude et al, 2007). These results suggest that not all dogs with clinical manifestations suggestive of CD can demonstrate CDV viruria by RT-PCR.…”

“…Alternatively, statistical evaluations of the neurological manifestations of 181 dogs infected by CDV have demonstrated that there were significant differences between the ages of dogs infected by CDV (Headley et al, 2012). Most of the neurological manifestations observed in the dogs with CDV viruria have been associated with CD (Tipold et al, 1992;Koutinas et al, 2002;Amude et al, 2007); however these studies did not analyse the clinical observations statistically. Nevertheless, most studies that have investigated the occurrence of CDV-induced neurological manifestations have demonstrated that myoclonus is the most frequently observed sign in dogs with CDE (Tipold et al, 1992;Koutinas et al, 2002;Amude et al, 2007).…”

“…Most of the neurological manifestations observed in the dogs with CDV viruria have been associated with CD (Tipold et al, 1992;Koutinas et al, 2002;Amude et al, 2007); however these studies did not analyse the clinical observations statistically. Nevertheless, most studies that have investigated the occurrence of CDV-induced neurological manifestations have demonstrated that myoclonus is the most frequently observed sign in dogs with CDE (Tipold et al, 1992;Koutinas et al, 2002;Amude et al, 2007). However, not all dogs that demonstrated myoclonus had CDV viruria; similar results using other clinical samples have been described (Koutinas et al, 2002;Amude et al, 2007).…”

“…Only dogs with clinical manifestations suggestive of infection by CDV (Amude et al, 2007;Headley et al, 2012) from February to September 2012 were included in this study. The main clinical signs considered as CDV-induced disease included pulmonary infection (bronchopneumonia, ocular-nasal purulent secretions), cutaneous lesions (abdominal pustules), neurological manifestations (e.g., myoclonus, convulsions, ataxia, locomotory difficulties, and motor incoordination), and hard-pad disease (hyperkeratosis).…”