Clinicopathological Features of Two Extremely Rare Hepatocellular Carcinoma Variants: a Brief Review of Fibrolamellar and Scirrhous Hepatocellular Carcinoma

Şamdancı, Emine; Akatlı, Ayşe Nur; Soylu, Neşe Karadağ

doi:10.1007/s12029-020-00500-1

Cited by 7 publications

(16 citation statements)

References 44 publications

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“…After these macroscopic definitions and macroscopic heterogeneity, it is necessary to mention microscopic heterogeneity. This heterogeneity is also reflected in the histopathological subtyping of HCC [71]. In the 5th edition of WHO classification of the tumors of the digestive system (2019), the subtypes of HCC are as follows; fibrolamellar, scirrhus, cear cell type, steatohepatitic, macrotrabecular massive, chromophobe, neutrophil-rich, lympocyte-rich [1].…”

Section: Pathological Featuresmentioning

confidence: 99%

Histopathological Features of the Steatohepatitic Variant of Hepatocellular Carcinoma and Its Relationship with Fatty Liver Disease

Şamdancı¹

2022

Hepatocellular Carcinoma - Challenges and Opportunities of a Multidisciplinary Approach

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Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver in adults. Steatohepatitic HCC (SH-HCC) is a recently described, rarer variant of HCC and is associated with nonalcoholic fatty liver disease (NAFLD). The relationship between fatty liver disease and/or steatohepatitis and SH-HCC is now known. This subtype can be confused with lipid-containing nodules (such as cirrhotic nodules, regenerative nodules, focal nodular hyperplasia) clinically, radiologically and histopathologically. Here, the histopathological features of SH-HCC, its relationship with fatty liver disease and briefly its clinical features will be discussed. In addition, histopathological features of this specific variant, immunohistochemical staining of the tumor and diagnostic difficulties in tru-cut biopsies will also be discussed. Actually, I think this article will raise clinicopathological awareness about this rare variant.

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Section: Pathological Featuresmentioning

confidence: 99%

Histopathological Features of the Steatohepatitic Variant of Hepatocellular Carcinoma and Its Relationship with Fatty Liver Disease

Şamdancı¹

2022

Hepatocellular Carcinoma - Challenges and Opportunities of a Multidisciplinary Approach

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“…4,5,[23][24][25] Grossly, S-HCC often appears as a multilobulated solid subcapsular mass that has a firm consistency due to the intratumoral fibrous content and thus appears somewhat similar to an iCCA on gross examination. [24][25][26] Tumor necrosis or hemorrhage is less frequent in S-HCC compared with conventional HCCs. 24,27 At low-power magnification, the tumor cells of S-HCCs form nests or trabeculae that appear embedded within a dense collagenous stroma.…”

Section: Scirrhous Hccmentioning

confidence: 99%

“…33 It is important that S-HCC is not to be confused for FLHCC, another subtype of HCC that also contains abundant intratumoral fibrous stroma. 26 Fibrolamellar HCC, which is more common in Western countries and very rare in Asia, shows unique clinical, histomorphological, and molecular characteristics. Clinically, it is mostly diagnosed in adolescents and young adults without underlying chronic liver disease and without the typical risk factors for HCC.…”

Section: Scirrhous Hccmentioning

confidence: 99%

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Histomorphological Subtypes of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma: Review and Update

Hwang¹,

Kim²

2022

AJSP: Reviews and Reports

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Primary liver cancers comprise a heterogeneous group of neoplasms, with the 2 main entities being hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA). Over the past decades, HCC and iCCA have been recognized to be heterogeneous in morphology, molecular features, and biological behavior, and the most recent World Health Organization classification of digestive system tumors describes various histomorphological subtypes of HCC and iCCA, some of which also have characteristic molecular features, clinical correlates, and prognostic implications. In this review, we discuss 4 recently described subtypes of HCC and iCCA-macrotrabecular HCC, steatohepatitic HCC, scirrhous HCC, and small duct iCCA-based on a series of cases.

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“…It is characterized by a central scar that could appear as a central area of hyperechogenicity. The next diagnostic step is frequently the computerized tomography (CT) study, in which FLHCC is shown as a lobulated lesion with good edge definition and a central scar with calcification nodules [ 5 ]. The enhancement is heterogeneous due to different portions of cellular and fibrous tissue.…”

Section: Introductionmentioning

confidence: 99%

Differential Diagnosis of Hepatic Mass with Central Scar: Focal Nodular Hyperplasia Mimicking Fibrolamellar Hepatocellular Carcinoma

et al. 2021

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Fibrolamellar hepatocellular carcinoma is a primary hepatic tumor that usually appears in young adults. Radical surgery is considered curative for this kind of tumor, so early diagnosis becomes essential for the prognosis of the patients. The main characteristic of this entity is the central scar, which is the center of differential diagnosis. We report the case of a 30-year-old man who was diagnosed with fibrolamellar hepatocellular carcinoma by ultrasonography. Contrast-enhanced CT confirmed this diagnosis, and the patient underwent a [18F] fluorocholine PET/CT. Hypermetabolism and the morphology in the nuclear medicine exploration suggest neoplastic nature of the lesion. Radical surgery was performed, and histopathologic analysis was performed, which resulted in focal nodular hyperplasia. Hepatic masses with central scar could have a difficult differential diagnosis, and focal nodular hyperplasia could mimic fibrolamellar hepatocellular carcinoma imaging patterns. These morphofunctional characteristics have not been described in [18F] Fluorocholine PET/CT, so there is a need to find out the potential role PET/CT in the differential diagnosis of hepatic mass with central scar.

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Clinicopathological Features of Two Extremely Rare Hepatocellular Carcinoma Variants: a Brief Review of Fibrolamellar and Scirrhous Hepatocellular Carcinoma

Cited by 7 publications

References 44 publications

Histopathological Features of the Steatohepatitic Variant of Hepatocellular Carcinoma and Its Relationship with Fatty Liver Disease

Histopathological Features of the Steatohepatitic Variant of Hepatocellular Carcinoma and Its Relationship with Fatty Liver Disease

Histomorphological Subtypes of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma: Review and Update

Differential Diagnosis of Hepatic Mass with Central Scar: Focal Nodular Hyperplasia Mimicking Fibrolamellar Hepatocellular Carcinoma

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