Clinicopathological features of patients with Borrmann type IV gastric carcinoma

Kim, Dong Yi; Kim, Hyeong Rok; Kim, Young Jin; Kim, Shin Kon

doi:10.1046/j.1445-2197.2002.02523.x

Cited by 38 publications

(48 citation statements)

References 10 publications

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“…Like our study, several others confirmed that the B IV was associated with known factors of poor [5][6][7]11,14,16 . Diagnosis in advanced stages, poorly differentiated histology, serosal invasion and high incidence of lymph node involvement are factors that directly influence the prognosis, causing lower rates of curative operations, which can vary between 31 and 52% 3,[5][6][7][8]20 and are in agreement with our data, which was 42.3% (52/123). Some series have shown that up to 2/3 of these patients underwent non-curative operations 17,20 , which is why Aranha 10 states that linitis plastica is not a surgical disease.…”

Section: Discussion Discussion Discussion Discussion Discussionsupporting

confidence: 88%

“…Despite advances in the treatment of gastric cancer, surgical results of B IV adenocarcinomas remain poor, the worst among all gastric carcinomas19. The survival rates at five years after curative gastrectomies rang from 11% to 33.4% 5,7,17,19 , confirming that they have lower rates compared to other Borrmann types 6,7,9 . In our patients, the overall survival at five years was 33%, similar to the ranges of variation found in the literature.…”

Section: Discussion Discussion Discussion Discussion Discussionmentioning

confidence: 70%

“…In most of these works, such variables were analyzed in groups of patients undergoing any type of gastric resection, without distinguishing curative from palliative approaches 3,5,7,9,[14][15][16][17][18][19] , while a smaller number detained on the study of these factors solely in the curative operation 8,11,20 , similar to our series. Like our study, several others confirmed that the B IV was associated with known factors of poor [5][6][7]11,14,16 . Diagnosis in advanced stages, poorly differentiated histology, serosal invasion and high incidence of lymph node involvement are factors that directly influence the prognosis, causing lower rates of curative operations, which can vary between 31 and 52% 3,[5][6][7][8]20 and are in agreement with our data, which was 42.3% (52/123).…”

Section: Discussion Discussion Discussion Discussion Discussionmentioning

confidence: 78%

“…In 1858, Brinton coined the term linitis plastica 4 to describe the infiltrative gastric carcinoma occupying the entire stomach (diffuse form), also called cirrous carcinoma in English literature 3 . Approximately 10 to 15% of all gastric adenocarcinomas are classified as type B IV, and some studies show its association with factors known to be of poor prognosis [5][6][7] . Thus, despite advances in treatment of gastric cancer, the surgical results of the B IV remains poor, with lower rates of curative resection [5][6][7][8] and survival 6,7,9 in comparison with other types of gastric carcinomas.…”

Section: Introduction Introduction Introduction Introduction Introducmentioning

confidence: 99%

“…The most appropriate operation to be performed remains a subject of discussion, although there is agreement that radical resection with D2 lymphadenectomy is associated with better outcomes, with increased survival time 5,7,11 . In this study we retrospectively evaluated the results obtained with resection with curative intent of B IV gastric adenocarcinoma through the analysis of clinical, surgical and pathological data, identifying which of these prognostic factors were associated with survival.…”

Section: Introduction Introduction Introduction Introduction Introducmentioning

confidence: 99%

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Adenocarcinoma gástrico Borrmann tipo IV: análise dos resultados da ressecção curativa

Accetta

Manso

Mello³

et al. 2011

Rev. Col. Bras. Cir.

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Results Results Results Results: Of the 123 patients studied, 68 underwent gastrectomy, 52 (42.3%) with curative intent and 16 (13%) palliative resection, while 55 (44.7%) had disease not subject to resection. Three postoperative deaths followed the curative resection, constituting a mortality rate of 5.76%. In nine (17.3%) patients there were technical complications, and esophagojejunal fistula seven cases, the most frequent. All technical complications and deaths occurred after total gastrectomy, which was the most commonly performed curative resection type in this series. The most common pattern of recurrence was peritoneal carcinomatosis. The location of the tumor, lymph node metastasis, lymphatic invasion and pathological staging were considered significant prognostic factors. The median survival time was 29 months, with a rate of five-year survival of 33% in patients undergoing curative resection. Conclusion Conclusion Conclusion Conclusion Conclusion: The curative resection of B IV gastric adenocarcinoma had a positive impact on survival of patients with the disease in stages IB, II and III, with up to 15 lymph nodes (pN2) and localized type.

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Section: Discussion Discussion Discussion Discussion Discussionsupporting

confidence: 88%

Section: Discussion Discussion Discussion Discussion Discussionmentioning

confidence: 70%

Section: Discussion Discussion Discussion Discussion Discussionmentioning

confidence: 78%

Section: Introduction Introduction Introduction Introduction Introducmentioning

confidence: 99%

Section: Introduction Introduction Introduction Introduction Introducmentioning

confidence: 99%

See 3 more Smart Citations

Adenocarcinoma gástrico Borrmann tipo IV: análise dos resultados da ressecção curativa

Accetta

Manso

Mello³

et al. 2011

Rev. Col. Bras. Cir.

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Muscle RAS oncogene homolog (MRAS) recurrent mutation in Borrmann type IV gastric cancer

et al. 2016

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The prognosis of patients with Borrmann type IV gastric cancer (Type IV) is extremely poor. Thus, there is an urgent need to elucidate the molecular mechanisms underlying the oncogenesis of Type IV and to identify new therapeutic targets. Although previous studies using whole‐exome and whole‐genome sequencing have elucidated genomic alterations in gastric cancer, none has focused on comprehensive genetic analysis of Type IV. To discover cancer‐relevant genes in Type IV, we performed whole‐exome sequencing and genome‐wide copy number analysis on 13 patients with Type IV. Exome sequencing identified 178 somatic mutations in protein‐coding sequences or at splice sites. Among the mutations, we found a mutation in muscle RAS oncogene homolog (MRAS), which is predicted to cause molecular dysfunction. MRAS belongs to the Ras subgroup of small G proteins, which includes the prototypic RAS oncogenes. We analyzed an additional 46 Type IV samples to investigate the frequency of MRAS mutation. There were eight nonsynonymous mutations (mutation frequency, 17%), showing that MRAS is recurrently mutated in Type IV. Copy number analysis identified six focal amplifications and one homozygous deletion, including insulin‐like growth factor 1 receptor (IGF1R) amplification. The samples with IGF1R amplification had remarkably higher IGF1R mRNA and protein expression levels compared with the other samples. This is the first report of MRAS recurrent mutation in human tumor samples. Our results suggest that MRAS mutation and IGF1R amplification could drive tumorigenesis of Type IV and could be new therapeutic targets.

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Association of the miR‐146aC>G, miR‐149T>C, miR‐196a2T>C, and miR‐499A>G polymorphisms with gastric cancer risk and survival in the korean population

Ahn

Rah

Choi

et al. 2012

Molecular Carcinogenesis

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We investigated whether four common microRNA polymorphisms (miR-146aC>G [rs2910164], miR-149T>C [rs2292832], miR-196a2T>C [rs11614913], and miR-499A>G [rs3746444]) are associated with the susceptibility and prognosis of gastric cancer in the Korean population. The four microRNA single-nucleotide polymorphisms (SNPs) were identified in a case-control study (461 patients; 447 controls) by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis in the Korean population. When patients were stratified into diffuse and intestinal-type gastric cancer groups, subjects with the miR-499AG and AG + GG genotypes had reduced adjusted odds ratios (AORs) for diffuse-type gastric cancer (AOR = 0.54 with 95% confidence interval [CI] = 0.31-0.97; AOR = 0.57 with 95% CI = 0.33-0.97). In the stratified analyses for gastric cancer risk, the miR-146aGG and CG + GG genotypes were associated with increased risk of gastric cancers among the non-smokers, whereas the miR-149TC and TC + CC genotypes showed lower risk of gastric cancer in males. The miR-196a2CC genotype was associated with elevated gastric cancer risk among females. For gastric cancer prognosis, intestinal-type gastric cancer patients with miR-146aCG + GG genotypes had significantly higher survival rates (log-rank P = 0.030) than patients with the CC genotype, and patients with the miR-499AA genotype had significantly increased survival rates compared to patients with the AG + GG genotypes (log-rank P = 0.013). When miR-146aCG + GG and miR-499AA genotypes were combined, the survival rate of intestinal-type gastric cancer patients was elevated (log-rank P < 0.001). No association was found between gastric or diffuse-type cancer prognosis and other miRNAs. Our data demonstrate that specific miRNA SNPs are associated with gastric cancer susceptibility (miR-499A>G) and prognosis (miR-146aC>G and miR-499A>G) in the Korean population depending on gastric cancer type.

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Clinicopathological features of patients with Borrmann type IV gastric carcinoma

Abstract: Improving the prognosis for patients with Borrmann type IV gastric carcinoma requires early detection and a curative resection.

Cited by 38 publications

References 10 publications

Adenocarcinoma gástrico Borrmann tipo IV: análise dos resultados da ressecção curativa

Adenocarcinoma gástrico Borrmann tipo IV: análise dos resultados da ressecção curativa

Muscle RAS oncogene homolog (MRAS) recurrent mutation in Borrmann type IV gastric cancer

Association of the miR‐146aC>G, miR‐149T>C, miR‐196a2T>C, and miR‐499A>G polymorphisms with gastric cancer risk and survival in the korean population

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