Clinicopathological features of inflammatory pseudotumour‐like follicular dendritic cell tumour of the abdomen

Chen, Yanyang; Shi, Huijuan; Li, Hui; Zhen, Tiantian; Han, Anjia

doi:10.1111/his.12851

Cited by 43 publications

(80 citation statements)

References 16 publications

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“…Extensive epithelioid granulomas and eosinophilic abscess formation can be rarely seen within the tumor . Studies have demonstrated positive EBER by in situ hybridization in almost all cases, frequent expression of the oncogenic protein EBV‐latent membrane protein‐1 by immunohistochemical stain, and monoclonal episomal EBV by southern blot analysis, suggesting a pathogenic role of EBV in this tumor …”

Section: Discussionmentioning

confidence: 99%

“…The tumor cells have morphologic, ultrastructural, and immunophenotypic features resembling those of normal follicular dendritic cells and can occur in both nodal and extranodal sites. Inflammatory pseudotumor‐like FDC sarcoma is regarded as a separate entity due to selective involvement to the liver and spleen, distinct pathologic features, and strong association with EBV . The tumor typically presents as a large, solitary, well‐circumscribed mass in liver or spleen.…”

Section: Discussionmentioning

confidence: 99%

“…Inflammatory pseudotumor‐like follicular dendritic cell (FDC) sarcoma is a rare malignant neoplasm almost exclusively arising from liver and spleen. Albeit it's slow‐growing and low‐grade nature, the recurrent rate has been reported around 10% . Due to morphological similarity, this tumor has been frequently confused with other inflammatory myofibroblastic proliferations, such as benign reactive inflammatory psuedotumor and inflammatory myofibroblastic tumor .…”

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confidence: 99%

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Cytological features of inflammatory pseudotumor‐like follicular dendritic cell sarcoma of spleen: A case report

Hang

Wang

Lai

2016

Diagnostic Cytopathology

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Here, we present the first cytological report of a primary splenic inflammatory pseudotumor-like follicular dendritic cell sarcoma. The 57 year-old male was incidentally found with a 2.2 cm well-demarcated splenic nodule. A sonography guided fine needle aspiration of the lesion was performed. The cytologic smears revealed loosely cohesive fragments of oval to spindle cells in a background of prominent lymphoplasmacytic infiltration. The cells showed sparse chromatin, distinct nucleoli, syncytial cell borders, and occasional cytoplasmic processes. On the liquid-based preparation, several histiocyte-like cells with emperipolesis phenomenon were noted. Scant large atypical cells with prominent, cherry-red nucleoli were found on the cell block sections. The initial cytologic interpretation was "atypical cells cannot exclude classical Hodgkin lymphoma." The subsequent partial splenectomy showed an inflammatory pseudotumor-like follicular dendritic cell sarcoma. The tumor cells were positive for CD21, CD35, smooth muscle actin, and EBER in situ hybridization. The cytologic differential diagnoses are briefly discussed. The knowledge of this rare entity, awareness of its cytomorphology, and proper ancillary tests would be helpful for correct cytologic diagnosis. Diagn. Cytopathol. 2017;45:230-234. © 2016 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Cytological features of inflammatory pseudotumor‐like follicular dendritic cell sarcoma of spleen: A case report

Hang

Wang

Lai

2016

Diagnostic Cytopathology

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“…From 1996 to date we retrieved 22 publications reporting IPT-like FDC tumors [11,15,35,[89][90][91][92][93][94][95][96][97][98][99][100][101][102][103][104][105][106][107]. There were 46 patients described: 24 female, 22 male (ratio 1.1:1), median age 57y (range 29-79y).…”

Section: Follicular Dendritic Cell Tumors Of the Spleenmentioning

confidence: 99%

Inflammatory pseudotumor-like follicular dendritic cell tumor: an underdiagnosed neoplasia

et al. 2017

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Follicular dendritic cell (FDC) tumor is an uncommon neoplasm. It generally presents as a slow-growing, painless mass, without systemic symptoms. Histological features usually include low grade spindle cell proliferation. This tumor occurs primarily in lymph nodes, especially cervical and axillary, however, involvement of extranodal sites such as the tonsils, spleen, liver, and gastrointestinal tract has been reported. Inflammatory pseudotumor-like follicular dendritic cell tumor (IPT-like FDCT) is a rare, distinctive histological subtype of this low-grade malignant neoplasm, with consistent Epstein-Barr virus (EBV) association. The differential diagnosis with other fibro-inflammatory tumor proliferations, as inflammatory pseudotumor (IPT) and inflammatory myofibroblastic tumor (IMT), may be challenging. In the present article, two cases of IPT-like FDCT of the spleen are presented, with a broad overview of the literature: one 77-year-old male and one 70-year-old female. A large immunohistochemical panel should be used for diagnosis, as no single specific and totally sensitive markers are available, including markers for CD21, CD23, CD35, CNA42, and clusterin. Individual cases may express one or more of these markers, so that all of them should be investigated. In situ hybridization for EBV is constantly positive. Immunostaining for ALK should be negative, as it is present in roughly half of the cases of IMT. This panel should be used in combination of clinical, laboratory, and topographic evidences. Importantly, inclusion of this lesion as a possible option in clinical and pathological investigation represents the basis for a correct diagnosis.

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“…IPT-like FDC tumors of liver are even more rare, and the clinicopathological nature of this type of disease remains unknown. First, the most common presentation of patients with FDC tumors is abdominal pain or weight loss, but IPT-like FDC tumors often grow without clinical symptoms or abdominal discomfort, as was the case in our patient (9). Second, IPT-like FDC tumors always exhibit a marked female predominance (10).…”

Section: Discussionmentioning

confidence: 65%

Hepatic inflammatory pseudotumour-like follicular dendritic cell tumor: A case report

Zhang

Zhu

et al. 2017

Molecular and Clinical Oncology

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Abstract. Hepatic inflammatory pseudotumor (IPT)-like follicular dendritic cell (FDC) tumor is a rare neoplasm. We herein report the case of 19-year-old female patient with an IPT-like FDC tumor and summarize 24 cases of hepatic FDC tumors previously reported in the English literature. The patient presented with complaints of abdominal discomfort, without significant laboratory abnormalities, and underwent surgical removal of a hepatic tumor. The resected tumor was 6 cm in the longest diameter and the tumor cells were positive for CD21, CD35 and Epstein-Barr virus (EBV). The postoperative course was uneventful and there have been no metastases or recurrence during 1 year of follow-up. The majority of the cases of hepatic IPT-like FDC tumors have a female predominance and exhibit an association with EBV infection. Their clinical manifestations and image findings are usually non-specific and the diagnosis of this disease mainly relies on pathology.

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Clinicopathological features of inflammatory pseudotumour‐like follicular dendritic cell tumour of the abdomen

Abstract: Inflammatory pseudotumour-like FDC tumour should be differentiated from inflammatory myofibroblastic tumour, Hodgkin lymphoma, interdigitating dendritic cell sarcoma, and gastrointestinal stromal tumour.

Cited by 43 publications

References 16 publications

Cytological features of inflammatory pseudotumor‐like follicular dendritic cell sarcoma of spleen: A case report

Cytological features of inflammatory pseudotumor‐like follicular dendritic cell sarcoma of spleen: A case report

Inflammatory pseudotumor-like follicular dendritic cell tumor: an underdiagnosed neoplasia

Hepatic inflammatory pseudotumour-like follicular dendritic cell tumor: A case report

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