Clinicopathological features of gastric inflammatory myofibroblastic tumor: Report of five cases

Abstract

The present study reported on the histomorphological observations and immunohistochemical features of five cases of gastric inflammatory myofibroblastic tumor (IMT). Loosely arranged fat fusiform myofibroblast-fibroblasts and diffusely or patchily distributed inflammatory cells, which formed a diverse morphological structure, were observed. In the mucous vascular structure, mucoid or collagenous areas, fibromatosis-or scar-like lesions were generally <10 mm in size and both had diffuse or patchy plasma cells, lymphocytes and other inflammatory-cell infiltration backgrounds. The immunophenotype was vimentin-and smooth muscle actin-positive with pan-cytokeratin, desmin and calponin expression and CD34-positive foci; furthermore, three cases were positive for anaplastic lymphoma kinase expression. Gastric IMT is rare, with unique histopathological changes and corrosion-like invasion of the smooth muscle of the stomach wall, blood vessels, nerves and adipose tissue. It should be differentiated from a variety of spindle cell tumor types and tumor-like lesions.

Gastric and cardiac inflammatory myofibroblastic tumor: an extremely rare case

“…The lack of specificity in the clinical presentation of IMT, which is often associated with the location of neoplasia growth, poses a diagnostic challenge. Immunohistochemistry is currently the most effective way to diagnose IMT, which is usually positive for vimentin and SMA and negative for CD34, CD117, and S100 [ 1 , 2 , 15 ]. In our experience, for patients who are eligible for pathologic biopsy, taking deeper tissue from the mass and doing immunohistochemistry can help to confirm the diagnosis of IMT preoperatively, while PET-CT can also play a supporting role in the diagnostic process.…”

A Rare Inflammatory Myofibroblastic Tumor of the Spleen: A Case Report

“…IMT is frequently observed in pediatric and adolescent populations. IMT occurs primarily in the lungs, but also in extrapulmonary sites throughout the body, with the most common being the liver, heart, orbit, central nervous system, and retroperitoneum (8)(9)(10)(11)(12). The underlying pathophysiological mechanism remains unidentified.…”

A pediatric tuberculosis with recurrent fever confirmed to be inflammatory myofibroblastic tumor

“…Most tumors are composed of spindle cells, accompanied by brosis, hyaline degeneration, calci cation, or necrosis. The in ammatory component may be variable, usually comprised of plasma cells, lymphocytes, eosinophils, and neutrophils [4,5]. There was a report that gene alterations, such as fusion of the gene encoding anaplastic lymphoma kinase (ALK) on chromosome 2p23 and tropomyosin 3 (TPM3), are detected in 30% of pediatric IMT cases [6].…”

“…The MIT diagnosis is based on pathological alternations, which may be challenging. IMT often presents as a circumscribed nodular mass, but multinodular lesions have also been described [4]. IMT has diverse morphological changes, including a paracellular spindle cell proliferation set in a predominantly hyalinized and chronically in amed background, and a highly cellular myo broblastic proliferation, as well as atypical neoplastic elements.…”