Clinicopathological Features of Ganglioneuroma Originating From the Adrenal Glands

Abstract

AGN was asymptomatic in most cases and diagnosis may be challenging. Adrenalectomy is a safe treatment modality for AGN and ensures favorable outcomes when diagnosed.

Left adrenal ganglioneuroma: Report of a new case

“…Adrenal ganglioneuromas are usually found to be silent and are incidentally discovered. In most cases AGNs are asymptomatic because of the nonhormone secreting nature of the tumor [ [7] , [8] ]. They may occasionally secrete catecholamines [ 3 ].…”

“…They present low attenuation on precontrast phase with increase in the postcontrast phase. Homogenous appearance in precontrast phase and heterogeneous in postcontrast phase is also another characteristic of neurogenic tumors [ 8 ]. The presence of punctate calcifications with no vessel involvement and low precontrast attenuation on CT should lead the physician to consider GN as a possible diagnosis [ 7 ].…”

Adrenal ganglioneuroma: What you need to know

“…Adrenal GNs are usually discovered incidentally due to the widespread use of computed tomography (Figure 1 ) and MRI (Figure 2 ) imaging techniques[ 2 , 11 ]. Particularly, GNs account for approximately 0.3%-2% of all adrenal incidentalomas[ 12 - 14 ]. In most cases, ultrasonography reveals a well-circumscribed, homogenous, hypo-echogenic lesion[ 15 ].…”

Ganglioneuromas across age groups: Systematic review of individual patient data

“…The majority of patients (76.4%) were from registries and case series focusing on children 5,8,10,15,19 or young patients (<28 years). 11 Reports including older adults were restricted to adrenal GN, 20,21 one explicitly excluding composite pheochromocytomas. 22 Inhomogenous reporting and differences in patient selection restricted meta-analysis to patient age and gender distribution.…”