Clinicopathological features of early gastric cancers arising in <i>Helicobacter pylori</i> uninfected patients

Sato, Chiko; Hirasawa, Kingo; Tateishi, Yoko; Ozeki, Yuichiro; Sawada, Atsushi; Ikeda, Ryosuke; Fukuchi, Takehide; Nishio, Masafumi; Kobayashi, Ryosuke; Makazu, Makomo; Kaneko, Hiroaki; Inayama, Yoshiaki; Maeda, Shin

doi:10.3748/wjg.v26.i20.2618

Cited by 24 publications

(39 citation statements)

References 53 publications

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“…Interval EGCs detected in the first and second periods were analyzed separately by HP infection status, and detection of HP-positive interval EGCs did not differ. The reason for this may be that HP-positive EGC lesions are relatively large in diameter and easily visible, while most HP negative gastric cancers are small gastric cancers (< 10 mm) [26,27], so the detection rate may have been sufficiently good even in the absence of QMS. In fact, the size of HP-positive gastric cancers detected during this study was larger than that of HP-negative gastric cancers (15.7 ± 4.4 mm vs 10.2 ± 3.8 mm, P = 0.003).…”

Section: E1905mentioning

confidence: 99%

“…Detection of HP-eradicated interval EGC and HP-naïve interval EGC significantly improved after the introduction. It has been reported that HP-negative EGCs are characterized by small-diameter and obscure lesions [26,[28][29][30]. We believe that the QMS was effective in maintaining endoscopist attention and identifying HP-negative EGC lesions during the examination; these lesions are small in diameter and obscure, and identification requires visualizing slight ▶ Table 6 Comparisons of background factors in patients with HP-negative interval and non-interval gastric cancers identified within 1 year.…”

Section: E1905mentioning

confidence: 99%

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Quality management system for screening esophagogastroduodenoscopy improves detection of Helicobacter pylori-negative interval gastric cancer

Ishibashi¹,

Kobayashi²,

Kawakami³

et al. 2021

Endosc Int Open

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Background and study aims Double-checking the findings of examinations is necessary for endoscopy quality control in gastric cancer screening; however, there have been no reports showing its effectiveness. We prospectively analyzed the effectiveness of a quality management system (QMS) in endoscopy for gastric cancer screening. Patients and methods QMS was defined as having images and reports checked by a second endoscopist on the same day and reporting inconsistencies to the examining endoscopist. Patients diagnosed with early gastric cancer (EGC) in the 2 years before and after the introduction of QMS were divided into two groups: the interval cancer group, which included those for whom cancer was detected within 1 year of the last endoscopy and the noninterval cancer group. Changes in detection rates were compared. Results Before the introduction of QMS, 11 interval EGC cases were diagnosed among 36,189 endoscopies, whereas after the introduction, 32 interval ECG cases were diagnosed among 38,290 endoscopies (P = 0.004). Fifteen noninterval EGC cases were diagnosed before the introduction, while 12 noninterval EGC cases were diagnosed after the introduction; no significant difference was observed. Subanalyses by Helicobacter pylori (HP) infection status revealed no difference in the detection rate among HP-positive EGC patients, but the detection rates among HP-eradicated and HP-naïve EGC patients were improved (P = 0.005 and P = 0.011). Logistic regression analysis showed that QMS was an independent predictor for detection of HP-negative interval EGC (P = 0.017, OR = 4.4, 95 % CI: 2.0–9.7). Conclusions QMS improved the detection rate for HP-negative interval early gastric cancer. (UMIN000042991)

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Section: E1905mentioning

confidence: 99%

Section: E1905mentioning

confidence: 99%

Quality management system for screening esophagogastroduodenoscopy improves detection of Helicobacter pylori-negative interval gastric cancer

Ishibashi¹,

Kobayashi²,

Kawakami³

et al. 2021

Endosc Int Open

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“…Age‐specific gastric cancer incidence and stage‐specific 5‐year survival rate were obtained from Japanese cancer statistics 10 . The responsibility rate of H. pylori infection for gastric cancer development was assumed to be 98% 2,3,4,5 . The incidence of gastric cancer in H. pylori ‐positive patients was estimated using the responsibility rate of H. pylori infection for gastric cancer development and the prevalence of H. pylori infection 2,3,4,5,12,16 .…”

Section: Methodsmentioning

confidence: 99%

“…More than half of the world's population is infected with Helicobacter pylori ( H. pylori ) 1 . H. pylori infection causes chronic atrophic gastritis, a common stage of progression to gastric cancer, and is responsible for 98% of the causes of gastric cancer in Japan 2,3,4,5 . Japan has the third highest age‐standardized rate for gastric cancer in the world 6 .…”

Section: Introductionmentioning

confidence: 99%

Economic and health impacts of introducing Helicobacter pylori eradication strategy into national gastric cancer policy in Japan: A cost‐effectiveness analysis

Kowada

Asaka

2021

Helicobacter

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Background Helicobacter pylori (H. pylori) eradication reduces gastric cancer risk. Since 2013, a population‐wide H. pylori eradication strategy for patients with chronic gastritis has begun to prevent gastric cancer in Japan. The aim of this study was to evaluate the economic and health effects of H. pylori eradication strategy in national gastric cancer prevention program. Materials and Methods We developed a cohort state‐transition model for H. pylori eradication and no eradication over a lifetime horizon from a healthcare payer perspective, and performed one‐way and probabilistic sensitivity analyses. We targeted a hypothetical cohort of H. pylori‐positive patients aged 20, 30, 40, 50, 60, 70, and 80. The main outcomes were costs, quality‐adjusted life‐years (QALYs), life expectancy life‐years (LYs), incremental cost‐effectiveness ratios, gastric cancer cases, and deaths from gastric cancer. Results H. pylori eradication was more effective and cost‐saving for all age groups than no eradication. Sensitivity analyses showed strong robustness of the results. From 2013‐2019 for 8.50 million patients, H. pylori eradication saved US$3.75 billion, increased 11.11 million QALYs and 0.45 million LYs, and prevented 284,188 cases and 65,060 deaths. For 35.59 million patients without eradication, H. pylori eradication has the potential to save US$14.82 billion, increase 43.10 million QALYs and 1.66 million LYs, and prevent 1,084,532 cases and 250,256 deaths. Conclusions National policy using population‐wide H. pylori eradication to prevent gastric cancer has significant cost savings and health impacts for young‐, middle‐, and old‐aged individuals in Japan. The findings strongly support the promotion of H. pylori eradication strategy for all age groups in high‐incidence countries.

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“…Khatoon et al showed the relationship between confirmed heterogeneity of the cag pathogenicity island gene and peptic ulcer disease in H. pylori strains and the effective prevention of peptic ulcer disease by the identification of H. pylori. 31,32 Stage IIID is characterized by histologically diffuse lymphocyte proliferation and a number of lymphatic follicles of varying sizes. H. pylori can also be detected in surface mucus cells surrounding lymphocyte proliferation and in areas of proliferating neck mucus cells.…”

Section: H Pylori Was Recently Shown To Reduce the Acidinduced Tightening Of Cell Junctions In Anmentioning

confidence: 99%

Follow-up analysis and histopathological study of gastric mucosa in patients withHelicobacter pyloriinfection

Zhao¹,

Zhang

Li³

et al. 2021

J Int Med Res

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Objective To investigate the histomorphological characteristics of the gastric mucosa and the prognosis in patients with Helicobacter pylori infection. Methods Progressive damage to the gastric mucosa was examined by immunohistochemistry in 2294 patients with H. pylori infection and follow-up information was analyzed. Results H. pylori initially colonized the mucus layer covered by the gastric mucosa epithelium, then selectively adhered to and destroyed the surface mucus cells causing intra-gastric and extra-gastric lesions. Gastric mucosal damage induced by H. pylori was divided into five stages according to the depth of H. pylori invasion and degree of lesion deterioration: mucilaginous, surface mucocellular, lamina propria lesion, mucosal atrophy, and intraepithelial neoplasia stages. Morphological follow-up analysis revealed no significant difference in 6-month curative effects between stage I and stage II, but significant differences were found between stages II and III, stages III and IV, and between stages IV and stage V, respectively. Conclusions This novel staging strategy may be a valuable tool for diagnosing and predicting the results of gastric mucosal damage induced by H. pylori infection.

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Clinicopathological features of early gastric cancers arising in Helicobacter pylori uninfected patients

Cited by 24 publications

References 53 publications

Quality management system for screening esophagogastroduodenoscopy improves detection of Helicobacter pylori-negative interval gastric cancer

Quality management system for screening esophagogastroduodenoscopy improves detection of Helicobacter pylori-negative interval gastric cancer

Economic and health impacts of introducing Helicobacter pylori eradication strategy into national gastric cancer policy in Japan: A cost‐effectiveness analysis

Follow-up analysis and histopathological study of gastric mucosa in patients withHelicobacter pyloriinfection

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