Clinicopathological Features in Bilateral Breast Cancer

Baykara, Meltem; Öztürk, Selçuk; Büyükberber, Süleyman; Helvacı, Kaan; Özdemir, Nuriye; Alkış, Necati; Berk, Velı; Koca, Doğan; Coşkun, Uğur; Öksüzoğlu, Berna; Uncu, Doğan; Arpaci, Erkan; Ustaalioğlu, Bala Basak Oven; Demırcı, Umut; Küçüköner, Mehmet; Dogu, Gamze Gokoz; Alıcı, Süleyman; Akman, Tülay; Özkan, Metin; Aslan, Ulku Yalcintas; Durnalı, Ayşe; Benekli, Mustafa

doi:10.7314/apjcp.2012.13.9.4571

Cited by 15 publications

(20 citation statements)

References 18 publications

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“…Like in most series, in the whole ‘multiple cancers’ group the invasive ductal histology was prevalent, although the proportion of invasive lobular subtype was somewhat lower than in some other series . Lower steroid receptor expression in mBBC in our series is consistent with other observations . We could not, however, demonstrate higher grade of mBBC, described in some series .…”

Section: Discussionsupporting

confidence: 87%

Are bilateral breast cancers and breast cancers coexisting with ovarian cancer different from solitary tumors? A pair‐matched immunohistochemical analysis aimed at intrinsic tumor phenotype

Senkus

Szade

Pieczyńska

et al. 2014

Pathology International

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Patients with bilateral breast cancer (BBC) and breast-ovarian cancer syndrome (BOCS) constitute populations potentially enriched for molecular defects involved in the pathomechanisms of these malignancies. The aim of our study was to compare tumor morphology and expression of estrogen and progesterone receptor, HER2, Ki67, cytokeratin 5/6, E-cadherin, vimentin and epidermal growth factor receptor in tissue microarrays from 199 tumors from BBC or BOCS patients and 199 age-matched solitary tumors. Compared to controls, BBC and BOCS considered jointly had lower incidence of DCIS, lower expression of PgR and HER2, and higher expression of Ki67 and vimentin. BOCS tumors were of higher grade, had lower expression of ER and PgR and higher expression of Ki67, CK5/6, vimentin and EGFR. BBC had less DCIS component, lower HER2 expression and higher Ki67 expression. Metachronous BBC (mBBC) had lower expression of ER, PgR and HER2, and higher expression of Ki67 and vimentin. Synchronous BBC (sBBC) had less DCIS component, higher expression of ER, and lower expression of CK5/6, EGFR and E-cadherin. BBC and breast cancers in BOCS differ in many aspects from solitary tumors. BBC are a heterogeneous group of tumors, differing between sBBC and mBBC. mBBC phenotype shares many features with BOCS tumors.

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Section: Discussionsupporting

confidence: 87%

Are bilateral breast cancers and breast cancers coexisting with ovarian cancer different from solitary tumors? A pair‐matched immunohistochemical analysis aimed at intrinsic tumor phenotype

Senkus

Szade

Pieczyńska

et al. 2014

Pathology International

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“…Although BBC is not frequent, MCBCis different from MFBC by having more advanced grade, stage, less ER expression, more frequent rates of local relapse and distant metastasis and better response to chemotherapy in case of relapse/metastasis [3]. Another study [4] demonstrated that among women with synchronous bilateral ER+/HER2-BC, recurrence score were concordant in 67% of cases.…”

Section: Discussionmentioning

confidence: 98%

“…In the study of Meltem Baykara et al [3] metachronous and synchronous groups showed similar age, menopausal status, tumor type, HER2/neu expression; but the family history, tumor grade, tumor stage, ER-negativity rate, local and distant metastases rates, surgery, adjuvant chemotherapy application rates were identified as significantly different. Although BBC is not frequent, MCBCis different from MFBC by having more advanced grade, stage, less ER expression, more frequent rates of local relapse and distant metastasis and better response to chemotherapy in case of relapse/metastasis [3].…”

Section: Discussionmentioning

confidence: 99%

“…This form of metastasis is rare in young women and occurs in advanced stages of the disease. Jobsen et al [2] noted MBBC showed a significant higher local failure compared to UBC and SBBC compared to MBBC and UBC had a significant higher distant metastases rate [3], disease-specific survival and OS were significantly worse for SBBC compared to UBC and MBBC [4], and the OS for MBBC compared to UBC, was significantly better [2].…”

Section: Discussionmentioning

confidence: 99%

“…Different publications suggest the same time to the same year for considering SBBC. Most of the publications proposed the contralateral tumor that was detected within the first 6 months as SBBC, tumors that developed after 6 months as MBBC [3]. The incidence of SBBC is reported to range from 0.8%-3.0%; largely reflecting differing definitions used for synchronous diagnoses, with cutoffs ranging from within 3-12 months of initial diagnosis [4].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Synchronous Bilateral Breast Cancer (SBBC): Report of a Case with Review of Literature

Ramezani¹,

Amiri²,

Kavousi³

et al. 2018

AJMCR

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The incidence of synchronous bilateral invasive breast cancer (SBBC) is reported to range from 0.8%-3.0%. Lower disease-free survival and high rates of distant metastasis is a recognized feature of bilateral synchronous tumors, which therefore have a worse overall survival compared to unilateral tumors. Early detection of the contralateral tumor is of utmost importance emphasizing the significance of breast self-examination. Here we report a case of SBBC with invasive ductal carcinoma on both sides in a 50-year-old lady. The pathology report on both sides was infiltrating ductal carcinoma and ductal carcinoma in situ, nuclear grade of ІІ/ІІІ and histologic grade of II/III. Perineural invasion was present on both sides but vascular invasion only on the right side. In conclusion, SBBC is rare, but is important because it may have worse prognosis, different hormone receptor status and treatment modality. Early detection with breast self-examination is highly emphasized.

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The prognostic comparison among unilateral, bilateral, synchronous bilateral, and metachronous bilateral breast cancer: A meta‐analysis of studies from recent decade (2008‐2018)

Pan

Zhou

et al. 2019

Cancer Medicine

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Background The incidence of bilateral breast cancer (BBC) is increasing nowadays comprising 2%‐11% of all breast cancer (BC). According to the interval time between the first and second cancer, BBC could be divided into synchronous (SBBC) and metachronous (MBBC). However, this interval time is quite different across studies. It remains controversial whether the survival of BBC, SBBC, and MBBC is similar or worse compared to that of unilateral breast cancer (UBC), and whether the survival of SBBC is similar or worse compared to MBBC. To better understand the survival of UBC, BBC, SBBC, and MBBC and how the interval time would influence the prognosis of SBBC and MBBC, we performed this meta‐analysis on studies from recent 10 years (2008‐2018). Methods Databases of PubMed, Embase, and Web of Science were searched for relevant studies within recent 10 years. Hazard ratio (HR) was adopted to evaluate the difference of overall survival (OS) of UBC, BBC, SBBC, and MBBC. HR of OS comparisons were performed between BBC vs UBC, SBBC vs UBC, MBBC vs UBC, and SBBC vs MBBC with 3, 6, 12 months as the interval time, respectively. Results There were 15 studies of 72 302 UBC and 2912 BBC included in the meta‐analysis. The summary HR of OS comparison between BBC vs UBC was 1.68 (95% CI: 1.28‐2.20), SBBC vs UBC was 2.01 (95% CI: 1.14‐3.55), MBBC vs UBC was 3.22 (95% CI: 0.75‐13.78). When 3, 6, 12 months were used as the interval time, the summary HR of the OS comparison between of SBBC vs MBBC were 0.64 (95% CI: 0.44‐0.94), 1.17 (95% CI: 0.84‐1.63) and 1.45 (95% CI: 1.10‐1.92), respectively. Conclusion BBC and SBBC showed worse prognosis in terms of OS compared to UBC while MBBC manifested similar or non‐superior survival as UBC. The OS comparison between SBBC and MBBC changed with different interval time used. The longer the interval time used, the worse the survival of SBBC. SBBC with interval of 3‐12 months between the two cancers had the worst prognosis. When 6 months was used to differentiate SBBC from MBBC, these two clinical entities showed similar OS.

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Clinicopathological Features in Bilateral Breast Cancer

Cited by 15 publications

References 18 publications

Are bilateral breast cancers and breast cancers coexisting with ovarian cancer different from solitary tumors? A pair‐matched immunohistochemical analysis aimed at intrinsic tumor phenotype

Are bilateral breast cancers and breast cancers coexisting with ovarian cancer different from solitary tumors? A pair‐matched immunohistochemical analysis aimed at intrinsic tumor phenotype

Synchronous Bilateral Breast Cancer (SBBC): Report of a Case with Review of Literature

The prognostic comparison among unilateral, bilateral, synchronous bilateral, and metachronous bilateral breast cancer: A meta‐analysis of studies from recent decade (2008‐2018)

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