Clinicopathological features and prognosis of mucinous cystic neoplasm with ovarian-type stroma: a multi-institutional study of the Japan Pancreas Society

YAMAO, Kenji; Yanagisawa, Akio; Takahashi, Kuniyuki; KIMURA, Wataru; Doi, Ryuichiro; Fukushima, Noriyoshi; OIKE, Nobuyuki; Shimizu, Mayuko; Hatori, Takashi; NOBUKAWA, Bunsei; HIFUMI, Michio; Kobayashi, Yuji; Tobita, Kosuke; TANNO, Satoshi; Sugiyama, Masanori; Miyasaka, Yoshihiro; NAKAGORI, Toshio; YAMAGUCHI, Taketo; Hanada, Keiji; ABE, Hideki; TADA, Minoru; Fujita, Naotaka; Tanaka, Masao

doi:10.2958/suizo.27.9

Cited by 47 publications

(86 citation statements)

References 9 publications

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“…IPMN are found throughout the gland with 20 to 25 % being multifocal whereas over 95 % of MCN occur in the body or tail of the pancreas and are essentially never multifocal. 9,10 Similarly, SCA and SPN are most often found as isolated lesions. Cystic PanNET are similarly isolated lesions but can be multifocal in patients with MEN I.…”

Section: Diagnosismentioning

confidence: 99%

“…A recent multicenter study from the Japanese Pancreas Society of 156 patients with surgically resected MCN found that 13.4 % had high-grade dysplasia, with only 3.9 % having invasive cancer. 10 A joint study in 163 individuals from the Massachusetts General Hospital and the University of Verona found HGD in 5.5 % and invasive carcinoma in 12 %. 9 One reason for the difference between the older and newer studies is that several of the older studies did not require the presence of ovarian stroma as a prerequisite for the diagnosis of MCN thus likely including side branch IPMN.…”

Section: Mcnmentioning

confidence: 99%

“…14 Even in patients with metastatic diseases, prognosis remains good with only 18.2 % of patients with metastases dying with a mean follow-up of 6.3 years (range [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16]. 31 Postoperative surveillance is normally performed with cross-sectional imaging every 6 months for 2 years and then annually for a total of 5 years.…”

Section: Spnmentioning

confidence: 99%

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Cystic Neoplasms of the Pancreas

Lennon

Wolfgang

2013

Journal of Gastrointestinal Surgery

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Pancreatic cysts are being identified with increasing frequency due to a combination of increased awareness and more frequent use of cross sectional imaging. Cystic neoplasms of the pancreas range from completely benign to frankly malignant. Identifying pre-malignant cysts offers the opportunity to prevent the development of pancreatic cancer. This article reviews the presentation, workup, and non-operative and operative management of premalignant and malignant pancreatic cysts.

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Section: Diagnosismentioning

confidence: 99%

Section: Mcnmentioning

confidence: 99%

Section: Spnmentioning

confidence: 99%

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Cystic Neoplasms of the Pancreas

Lennon

Wolfgang

2013

Journal of Gastrointestinal Surgery

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“…In experienced centers, the complication rate is <1%. 5 The adoption of EUS-FNA as a valuable diagnostic tool is not universal because of the reported risk of mucin spillage and peritoneal contamination during the procedure by some 6,7 and because of the lack of expertise in both the procedure and cytologic interpretation by others. 8 Given the shift in patient management toward conservative, nonsurgical management in a large percentage of patients with pancreatic cysts, 9-11 the added value of cyst fluid analysis is important.…”

Section: Introductionmentioning

confidence: 99%

Prospective analysis of atypical epithelial cells as a high‐risk cytologic feature for malignancy in pancreatic cysts

Pitman

Yaeger

Brugge

et al. 2012

Cancer Cytopathology

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BACKGROUND: Pancreatic cysts are aspirated to assess whether a cyst is mucinous on one hand and malignant on the other. The authors' retrospective data have indicated that high-grade atypical epithelial cells (AECs) identified on cytology are a high-risk feature and a better threshold than ''positive'' for detecting malignancy. The objective of the current study was to assess the accuracy of AECs in predicting malignancy in pancreatic cysts.

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“…10-17 23,24 Solid pseudopapillary neoplasm Rare. Occurs more often in young female (mean age, 30 y).…”

Section: -68mentioning

confidence: 99%

Clinical Approach to Incidental Pancreatic Cystic Neoplasm in Outpatient Clinics

Woo

Lee

2017

Korean J Gastroenterol

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Cystic lesions of the pancreas are increasingly observed due to increased use of abdominal images. The malignant rate of pancreas cystic lesion varies widely between various types. Identification of malignant or high-risk lesions is important when determining the appropriate course of management. Using these image findings, including cyst size, presence of solid components, and pancreatic duct involvement, the 2012 International Association of Pancreatology (IAP) and the 2015 American Gastroenterological Association (AGA) guidelines provide a rationale in identifying higher risk patients requiring further workups using an endoscopic ultrasound (EUS). EUS with fine needle aspiration and cytology allows confirmation of the cyst type and determines the risk of malignancy. Small cysts with no suspicious features may undergo the regular imaging study for regular surveillance due to low risk for malignancy. In this review, the differences between the 2012 IAP and 2015 AGA guidelines are presented, In addition to possible recommendations for management and surveillance.

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Clinicopathological features and prognosis of mucinous cystic neoplasm with ovarian-type stroma: a multi-institutional study of the Japan Pancreas Society

Cited by 47 publications

References 9 publications

Cystic Neoplasms of the Pancreas

Cystic Neoplasms of the Pancreas

Prospective analysis of atypical epithelial cells as a high‐risk cytologic feature for malignancy in pancreatic cysts

Clinical Approach to Incidental Pancreatic Cystic Neoplasm in Outpatient Clinics

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