Clinicopathological features and prognosis of gastric cancer in young European adults

Santoro, Roberto; Carboni, Fabio; Lepiane, Pasquale; Ettorre, Giuseppe Maria; Santoro, Eugenio

doi:10.1002/bjs.5600

Cited by 119 publications

(143 citation statements)

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“…GC patients younger than 40 years are rare; approximately 2-16.2% of GC occurs in patients younger than 40 years old (Santoro et al, 2007;Kuling et al, 2008;Dhobi et al, 2013), and only 1.1-3.3% of cases occur in patients younger than 30 years of age (Lim et al, 2003). The preponderance of evidence showed that there are differences in the clinicopathological features and molecular mechanism of gastric carcinoma between young and older patients (Quispe et al, 2000;Lim et al, 2003;Hajmanoocheri et al, 2013a;2013b).…”

Section: Clinicopathological and P53 Gene Alteration Comparison Betwementioning

confidence: 99%

“…Gastric cancer is one of the most common gastrointestinal malignancies worldwide and every year ~1 million new cases of GC are diagnosed and 740,000 die of this disease worldwide (Parkin et al, 2005;Santoro et al, 2007;Ferlay et al, 2013;Guggenheim et al, 2013;Karim et al, 2013). Although recent developments in medical screening has decreased the incidence of advanced GC, still GC in youngsters remains a serious problem as routine screening in many countries including India does to diagnose in young people and is asymptomatic even in the advanced stages of the disease (IARC, 2001;Isobe et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Clinicopathological and p53 Gene Alteration Comparison between Young and Older Patients with Gastric Cancer

Karim¹

2014

Asian Pacific Journal of Cancer Prevention

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Section: Clinicopathological and P53 Gene Alteration Comparison Betwementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinicopathological and p53 Gene Alteration Comparison between Young and Older Patients with Gastric Cancer

Karim¹

2014

Asian Pacific Journal of Cancer Prevention

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“…Only few studies have addressed the absence of positive family history in elderly gastric cancer patients [2] as compared to patients aged 45 years or less [3,10]. In Western countries, a hereditary type of diffuse, poorly-differentiated, infiltrative adenocarcinoma has been described in young patients.…”

Section: Family Historymentioning

confidence: 99%

Gastric cancer in the elderly: An overview

Saif

Makrilia

Zalonis

et al. 2010

European Journal of Surgical Oncology (EJSO)

138

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Aims: Gastric cancer in the elderly represents a distinct entity with specific clinicopathological characteristics and the majority of affected patients belong to this age group. Subtotal or total gastrectomy with radical lymph node dissection, adjuvant chemo-radiotherapy or perioperative chemotherapy represent the only potentially curative treatment options and seem to be performed with acceptable morbidity and mortality rates in selected elderly patients. Published research is very limited due to the strict selection and under-representation of elderly patients in clinical trials. A review of current recommendations and practice was performed.Methods: A comprehensive literature review was performed searching Medline for articles published since 1974, using "gastric cancer", "elderly" and "treatment" as key words.Observations: The data suggest that elderly patients that fulfill the inclusion criteria of clinical trials experience the same advantages and toxicities from chemotherapy as younger patients. Fit elderly patients with operable gastric cancer should be canndidates for the standard surgical resection provided that pre-operative comorbidities are taken into account. Peri-operative chemotherapy or post-operative chemoradiotherapy should be added in case of locally advanced disease. Palliative systemic chemotherapy seems to prolong survival in recurrent and metastatic disease.Conclusions: Chronological age alone is not sufficient reason to withhold curative or palliative treatment from an elderly gastric cancer patient. Performance status does not suffice in order to estimate the general condition of elderly patients and cofactors regarding their functional, social and mental status have to be considered.Word count (abstract): 234

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“…Factors that contribute to the poor prognosis of gastric cancer in the young include delayed detection, resulting in an advanced stage at presentation, diffuse infiltration of the tumor and a poorly differentiated histology [1,4,10]. On the other hand, recent studies have indicated that prognosis in young patients is equivalent to [7,11,12] or better than that in middle-aged patients with cancers at the same stage [8,9,13,14]. Thus, the concept of gastric cancer having a poorer prognosis in relatively young patients remains controversial.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological features of gastric cancer in young patients

et al. 2015

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Background Early-onset gastric cancer is relatively rare. To evaluate the clinicopathological features and surgical outcome of young patients with gastric cancer, this retrospective comparative study was conducted. Methods From 2000 to 2010, 4882 patients underwent surgery for gastric adenocarcinoma in our institution. A total of 136 patients under 40 years old were enrolled as the young group, and a total of 1435 patients aged between 60 and 69 were identified as the control group for this study. The patient's characteristics, pathological findings, surgical and clinical outcomes were reviewed, and the risk factors of recurrence were compared between the two groups. Results Among the young group, patients had significantly fewer comorbidities and postoperative complications. The patient proportion having 7 or more lymph node metastases was higher in the young group (25 %) than in the control group (16 %). The presence of lymph node metastasis was identified as a strong risk factor for recurrence (odds ratio = 4.31) in the young group according to the results of the step-wise logistic regression analysis. Although the disease-specific survival at stage II was relatively better in the young group (p = 0.0439) than in the control group, there were no significant differences in overall survival for all stages. Conclusion Early-onset gastric cancer is likely to present lymph node metastases. The survival rate of gastric cancer in young patients was equivalent to that in patients in their 60s, which is the typical age at onset.

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Clinicopathological features and prognosis of gastric cancer in young European adults

Abstract: Gastric cancer in young adults tends to be more advanced; however, when matched for stage, the prognosis does not differ from that of older patients.

Cited by 119 publications

References 15 publications

Clinicopathological and p53 Gene Alteration Comparison between Young and Older Patients with Gastric Cancer

Clinicopathological and p53 Gene Alteration Comparison between Young and Older Patients with Gastric Cancer

Gastric cancer in the elderly: An overview

Clinicopathological features of gastric cancer in young patients

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