Clinicopathological features and molecular markers of breast cancer in Jos, Nigeria

Gukas, Isaac D.; Jennings, Barbara; Mandong, BM; Igun, GO; Girling, Anne; Manasseh, A N; Ugwu, B T; Leinster, Sam

doi:10.4314/wajm.v24i3.28220

Cited by 48 publications

(55 citation statements)

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“…23 Analysis of ER/PR status in Nigeria showed similar results wherein 75% of the cases presented with ER-negative and 72% of cases PR-negative tumors. 24 Similar hormonal status expression was observed in African-American women who presented with ER-negative tumors. 25 In conclusion, this study suggests that the typical breast cancer patient in central Sudan tends to be a younger, premenopausal woman living in a rural area and presenting with advanced disease likely to be ER/PR negative.…”

Section: Dovepresssupporting

confidence: 54%

Breast cancer burden in central Sudan

Elgaili

Abuidris²,

Rahman³

et al. 2010

IJWH

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Breast cancer is a worldwide disease resulting in many deaths. Although breast cancer incidence is lower in Sub-Saharan African countries than in developed countries, African women are more likely than women in the developed world to be diagnosed at later stages of the disease and, thus, are more likely to die from it. This is due to the lack of awareness by women, accessibility to screening methods, and availability of African-based research findings that would influence decision making at the governmental level. This descriptive study was undertaken to shed light on the type, stage and age distribution of breast cancer at diagnosis in women living in central Sudan encompassing al-Gezira, Blue Nile, White Nile, and Sennar States. Cases comprised 1255 women from central Sudan diagnosed with breast cancer and referred to and treated at Institute of Nuclear Medicine, Molecular Biology, and Oncology, from January 1999 to December 2006. Data revealed that 74% of the women were 50 years old or premenopausal. Invasive ductal carcinoma was the most common pathology (82%) and women presenting with stage III or higher tumors that had already metastasized, while ductal carcinoma in situ was the least prevalent (0.5%) finding. Estrogen and progesterone receptors expression were performed on a limited number of samples and the overwhelming majority of cases were observed to be negative for estrogen and progesterone receptors expression.

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Section: Dovepresssupporting

confidence: 54%

Breast cancer burden in central Sudan

Elgaili

Abuidris²,

Rahman³

et al. 2010

IJWH

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“…(16) Early age at onset and aggressive clinical features have frequently been documented in clinical series from Africa and case series from several centers in Africa have reported that hormone receptor-negative cases are predominant (17)(18)(19), for example, only 25% of cases in a large multicenter series of patients from West Africa were ERpositive, less than half that observed in the U.S. Black (20,21). However, these findings from Africa were based on archival materials and the role of antigen degradation and false negative results could not be ruled out (18).…”

Section: Discussionmentioning

confidence: 99%

Cancer in Africa 2012

Parkin

Bray

Ferlay

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

294

280

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Background: Noncommunicable diseases, and especially cancers, are recognized as an increasing problem for low and middle income countries. Effective control programs require adequate information on the size, nature, and evolution of the health problem that they pose.Methods: We present estimates of the incidence and mortality of cancer in Africa in 2012, derived from "GLOBOCAN 2012," published by the International Agency for Research on Cancer.Results: There were 847,000 new cancer cases (6% of the world total) and 591,000 deaths (7.2% of the world total) in the 54 countries of Africa in 2012, with about three quarters in the 47 countries of Sub-Saharan Africa. While the cancer profiles often differ markedly between regions, the most common cancers in men were prostate (16.4% of new cancers), liver (10.7%), and Kaposi sarcoma (6.7%); in women, by far the most important are cancers of the breast (27.6% of all cancers) and cervix uteri (20.4%).Conclusions: There are still deficiencies in surveillance systems, particularly in Sub-Saharan Africa and, specifically, of their most vital component, population-based cancer registries. With the number of annual cancer cases and deaths likely to increase by at least 70% by 2030, there is a pressing need for a coordinated approach to improving the extent and quality of services for cancer control in Africa, and better surveillance systems with which they can be planned and monitored.Impact: The results are the best data currently available and provide a reasonable appraisal of the cancer situation in Africa. Cancer Epidemiol Biomarkers Prev; 23(6); 953-66. Ó2014 AACR.

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“…There are few studies of breast cancer in African patients and these suggest that majority of tumors are ER negative, PR negative and are of basal cell type [14,15]. Almost all of these studies rely on archival tissue of variable quality; therefore their conclusions may be inaccurate.…”

Section: Introductionmentioning

confidence: 99%