Clinicopathological features and incidence rate of oxyntic gland neoplasm: A single center retrospective study

Abstract

In this retrospective study, we aimed to examine oxyntic gland neoplasms (OGNs) identified in patients visiting an internal medicine clinic over a 40-month follow-up period. Additionally, we wished to clarify the clinicopathological characteristics and frequency of occurrence of these lesions. From December 1, 2017 to March 31, 2021, we performed 13,240 upper gastrointestinal endoscopies on 7488 patients. Of these, we identified 27 patients with 30 histopathologically confirmed OGNs, yielding a disease frequency of 0.36% (27/7488). Further, in three of 27 patients (11%), multiple simultaneous lesions had occurred. One of the 30 lesions (3.3%) was present in the antrum. Nine of the 9 patients (33%) had no history of Helicobacter pylori infection, and remaining 18 (67%) were either currently or previously infected. However, 27/30 lesions (90%) occurred in non-atrophied regions. After endoscopic treatment, submucosal infiltration was observed in eight (47%) of the 17 lesions that underwent histopathological evaluations, which showed no submucosal desmoplasia in all eight cases. Additional resection was not performed while patient progress has been monitored. No cases of recurrence have been reported. In conclusion, we found that the frequency of oxyntic gland neoplasms was much higher than previously reported.