Clinicopathological factors influencing the number of stages of Mohs surgery for basal cell carcinoma

Calvão, Joana; Pinho, André; Brinca, Ana; Vieira, Ricardo

doi:10.1016/j.abd.2021.08.007

Cited by 5 publications

(3 citation statements)

References 14 publications

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“…There is no real- time ability to evaluate whether or not the lesion was completely removed and, consequently, high risk that the residual tumor will remain at the excision site [ 16 ]. Mohs micrographic surgery (MMS) technique achieves high cure rates (~99%) using intraoperative evaluation of hematoxylin and eosin (H&E) histopathology for intraoperative margin control [ 17 , 18 ]. This method utilizes horizontal tissue sectioning to enable inspection of the entire surgical margin [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Design and Validation of a Handheld Optical Polarization Imager for Preoperative Delineation of Basal Cell Carcinoma

Jermain

Iorizzo

Maloney

et al. 2022

Cancers

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Background: Accurate removal of basal cell carcinoma (BCC) is challenging due to the subtle contrast between cancerous and normal skin. A method aiding with preoperative delineation of BCC margins would be valuable. The aim of this study was to implement and clinically validate a novel handheld optical polarization imaging (OPI) device for rapid, noninvasive, in vivo assessment of skin cancer margins. Methods: The handheld imager was designed, built, and tested. For clinical validation, 10 subjects with biopsy-confirmed BCC were imaged. Presumable cancer margins were marked by the study surgeon. The optical images were spectrally encoded to mitigate the impact of endogenous skin chromophores. The results of OPI and of the surgeon’s preoperative visual assessment were compared to clinical intraoperative histopathology. Results: As compared to the previous prototype, the handheld imager incorporates automated image processing and has 10-times shorter acquisition times. It is twice as light and provides twice as large a field of view. Clinical validation demonstrated that margin assessments using OPI were more accurate than visual assessment by the surgeon. The images were in good correlation with histology in 9 out of 10 cases. Conclusions: Handheld OPI could improve the outcomes of skin cancer treatments without impairing clinical workflows.

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Section: Introductionmentioning

confidence: 99%

Design and Validation of a Handheld Optical Polarization Imager for Preoperative Delineation of Basal Cell Carcinoma

Jermain

Iorizzo

Maloney

et al. 2022

Cancers

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“…It is idealism to preserve as much normal skin tissue as possible while removing the tumor. Mohs Micrographic Surgery (MMS), which allows complete histological examination of tumor margins during surgery, is the first choice for treatment of refractory skin cancers 2 . However, clinicians need to undergo appropriate training before performing MMS, intraoperative simultaneous cooperation from pathologists, time‐consuming and expensive procedures limit the widespread application of this technology.…”

mentioning

confidence: 99%

“…Mohs Micrographic Surgery (MMS), which allows complete histological examination of tumor margins during surgery, is the first choice for treatment of refractory skin cancers. 2 However, clinicians need to undergo appropriate training before performing MMS, intraoperative simultaneous cooperation from pathologists, time-consuming and expensive procedures limit the widespread application of this technology. Therefore, the simple and rapid traditional surgical excision is still the most common method of treating BCC.…”

mentioning

confidence: 99%

Usefulness of Shear Wave Elastography in Determining the Tumor Extent of Basal Cell Carcinomas

Liang

Feng

Wang

et al. 2022

J of Ultrasound Medicine

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Objectives-The purpose of this study was to investigate the value of shear wave elastography (SWE) in determining tumor extent of basal cell carcinomas (BCC), and thereby determine the optimal surgical margins (OSM).Methods-10 patients (40 surgical margins) with BCC were collected, the visual observation boundaries (VOB) were marked, and the SWE parameters of soft tissues were measured 1 mm intervals in "3, 6, 9, 12" clock directions, starting from VOB. Then tumors were resected with a 5 mm surgical margin outward expansion of VOB. All specimens were examined pathologically 1 mm intervals from VOB in four clock directions. With the positive margins furthest from the tumor as the real tumor boundaries (RTB) and the negative margins closest to the tumor as the optimal surgical margins (OSM). The SWE parameters were compared between these two groups.Results-The elasticity ratio (E ratio ) of average young's modulus between region of interest and adjacent normal soft tissue had statistically significant differences between groups (P = .000), while other parameters show no difference. The E ratio of RTB and OSM were 1.22 AE 0.14 and 0.99 AE 0.07. The area under the ROC curve was .947. Taking 1.075 as the threshold of E ratio for the diagnosis of tumor extent, the sensitivity, specificity and accuracy were 87.5%, 90.0% and 90.0%. The surgical margins designed according to OSM were better than those designed according to VOB + 5 mm (P = .000).Conclusions-The E ratio of SWE is helpful in determining tumor extent of BCC. This is beneficial for surgical margin designing.

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Basal cell carcinoma has greater subclinical extension than squamous cell carcinoma: a cohort study

Rahman,

Hooper,

Rohrer

2024

Arch Dermatol Res

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Clinicopathological factors influencing the number of stages of Mohs surgery for basal cell carcinoma

Cited by 5 publications

References 14 publications

Design and Validation of a Handheld Optical Polarization Imager for Preoperative Delineation of Basal Cell Carcinoma

Design and Validation of a Handheld Optical Polarization Imager for Preoperative Delineation of Basal Cell Carcinoma

Usefulness of Shear Wave Elastography in Determining the Tumor Extent of Basal Cell Carcinomas

Basal cell carcinoma has greater subclinical extension than squamous cell carcinoma: a cohort study

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