Clinicopathological characteristics of mucinous carcinoma of the colon and rectum

Nozoe, Tetsuo; Anai, Hideaki; Nasu, Shinji; Sugimachi, Keizō

doi:10.1002/1096-9098(200010)75:2<103::aid-jso6>3.0.co;2-c

Cited by 156 publications

(95 citation statements)

References 25 publications

(37 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[1][2][3] Colorectal mucinous adenocarcinoma and signet-ring cell carcinoma are adenocarcinomas in which the cancer cells produce excess mucin. A unique pathologic feature of signet-ring cell carcinoma is the presence of signetring cells, which are single tumor cells with intracytoplasmic mucin that displaces their nuclei.…”

mentioning

confidence: 99%

“…In contrast, mucinous adenocarcinoma is characterized by abundant extracellular mucin produced by tumor cells. Mucinous adenocarcinoma shares some clinical characteristics with signetring cell carcinoma, such as affecting younger patients, 4,5 lymph node metastases, 2 and advanced stage at presentation. 2,4,5 Both colorectal mucinous adenocarcinoma and signet-ring cell carcinoma are associated with high-frequency microsatellite instability.…”

mentioning

confidence: 99%

“…Mucinous adenocarcinoma shares some clinical characteristics with signetring cell carcinoma, such as affecting younger patients, 4,5 lymph node metastases, 2 and advanced stage at presentation. 2,4,5 Both colorectal mucinous adenocarcinoma and signet-ring cell carcinoma are associated with high-frequency microsatellite instability. [6][7][8] We also believe that there are clinicopathological differences between mucinous adenocarcinomas and signet-ring cell carcinomas, especially in the aggressiveness of biological behavior.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Clinical significance of signet-ring cells in colorectal mucinous adenocarcinoma

et al. 2008

View full text Add to dashboard Cite

Mucin occasionally accumulates intracellularly in colorectal mucinous adenocarcinomas, resulting in signetring cell morphology. In the current practice of pathology, there is no definitive rule on how to report a minor component of signet-ring cells in colorectal mucinous adenocarcinomas. We hypothesized that the absence of signet-ring cell component might have a favorable effect on survival of mucinous adenocarcinoma patients. To assess the biological characteristics of colorectal mucinous adenocarcinoma, we analyzed its clinicopathological features, microsatellite instability status, and survival outcomes and compared them with those of colorectal signet-ring cell carcinoma. A total of 266 consecutive colorectal mucinous adenocarcinoma patients and 65 signet-ring cell carcinoma patients were included. Mucinous adenocarcinomas, by comparison with signet-ring cell carcinomas, were characterized by development at an older age, less frequent vascular invasion and lymph node metastasis, and lower TNM stage at presentation. A total of 21 (22%) of 95 mucinous adenocarcinomas and 12 (19%) of 63 signet-ring cell carcinomas were high-frequency microsatellite instability. Patients with mucinous adenocarcinoma had significantly better survival than those with signet-ring cell carcinoma (Po0.0001) or than those with signet-ring cell carcinoma showing 450% extracellular mucin by volume (Po0.0001). In univariate analysis, absence of signet-ring cell component (P ¼ 0.0197), absence of vascular invasion, decreased invasion depth, no lymph node metastasis, and lower TNM stage had a favorable effect on survival of mucinous adenocarcinoma patients. Absence of vascular invasion, no lymph node metastasis, and lower TNM stage had a favorable effect on survival of signet-ring cell carcinoma patients. Multivariate analysis showed that higher TNM stage and T stage 4 were independent predictors of poor outcome in patients with mucinous adenocarcinoma. Our observations strongly suggest that pathologists should report the percentage of signet-ring cell component in colorectal mucinous adenocarcinomas and mucinous adenocarcinoma has different biologic behavior compared with signet-ring cell carcinoma. Modern Pathology (2008Pathology ( ) 21, 1533Pathology ( -1541 doi:10.1038/modpathol.2008 published online 10 October 2008 Keywords: colorectal mucinous adenocarcinoma; signet-ring cell; survival Although colorectal adenocarcinoma has a relatively better prognosis than other gastrointestinal malignancies with the same stage, specific histological types of colorectal carcinoma such as mucinous adenocarcinoma and signet-ring cell carcinoma have a poor prognosis. 1-3 Colorectal mucinous adenocarcinoma and signet-ring cell carcinoma are adenocarcinomas in which the cancer cells produce excess mucin. A unique pathologic feature of signet-ring cell carcinoma is the presence of signetring cells, which are single tumor cells with intracytoplasmic mucin that displaces their nuclei. The infiltrating cells spread diffusely throughout the bowel wall. I...

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Clinical significance of signet-ring cells in colorectal mucinous adenocarcinoma

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Mucinous carcinoma accounts for between 5 and 20 % of all colorectal cancers [5][6][7][8]. It is relatively rare to find such tumours in the rectum, being most commonly found in the proximal colon.…”

Section: Epidemiology and Clinical Characteristicsmentioning

confidence: 99%

“…Previous studies have used varying proportions of mucin to define these tumours [3,4]. They represent 5-20 % of all colorectal cancers [5][6][7][8] and are generally considered to have a worse prognosis than nonmucinous tumours of the rectum. Furthermore, they are also suggested to have a limited response to oncological treatments.…”

Section: Introductionmentioning

confidence: 99%

Mucinous carcinoma of the rectum: a distinct clinicopathological entity

Chand

Swift

et al. 2013

Tech Coloproctol

View full text Add to dashboard Cite

Purpose The definition of mucinous tumours relies on quantification of the amount of mucus produced by neoplastic cells within the rectum. This has changed over the years to include varying degrees of mucin production. The inconsistency of diagnosis has led to conflicting reports in the literature regarding clinical outcomes and treatment response. A universally accepted definition and improved imaging and surgical techniques in the last decade are now challenging the traditional view of these tumours. The aim of this review was to present the current evidence on the clinicopathological characteristics of mucinous tumours of the rectum. Methods A systematic review was conducted using Preferred Reporting for Systematic Reviews and Meta-Analyses guidelines. A literature search was performed using the Ovid SP to search both EMBASE and MEDLINE databases, Google Scholar and PubMed to find all studies relating to mucinous carcinoma of the rectum. The search dates were between 1 January 1965 and 1 March 2013. Results Mucinous tumours comprise 5-20 % of all rectal cancers and commonly present at a more advanced stage and in younger patients. They are readily identified on MRI, and the diagnosis is confirmed on histological analysis, demonstrating more than 50 % of extracellular mucin within the tumour complex. They carry an overall worse prognosis compared to adenocarcinoma of the same stage. The response to oncological treatment remains controversial. Conclusion Mucinous tumours of the rectum are less well understood than non-mucinous adenocarcinoma. This is due to the inconsistent histopathological definitions of the past making comparison of clinical outcome data difficult. They remain challenging to treat and are associated with a poor prognosis. A universally accepted definition and the role of imaging techniques such as MRI to accurately detect mucinous tumours are likely to lead to a better understanding of these cancers.

show abstract

Mucinous carcinomas of the colon and rectum show higher rates of microsatellite instability and lower rates of chromosomal instability

Kazama

Watanabe

Kanazawa

et al. 2005

Cancer

View full text Add to dashboard Cite

BACKGROUNDThe clinicopathologic significance of mucinous carcinomas (Muc) of the colon and rectum has been widely discussed, but there have been few studies on Muc regarding genetic and epigenetic alterations. The current study analyzed genetic and epigenetic alterations of Muc to clarify their differences from well differentiated adenocarcinomas (WD).METHODSThirty‐nine cases of Muc and 39 cases of WD were investigated. Cases of WD were matched with cases of Muc for T classification and tumor location. Microsatellite instability (MSI) status and loss of heterozygosity (LOH) of four loci (2p, 5q, 17p, 18q) were evaluated. The methylation status of the hMLH1 promoter region in Muc was also examined.RESULTS“MSI tumors” were defined as those that showed MSI‐high, and “chromosomal instability (CIN) tumors” were defined as those that showed LOH but not MSI‐high. MSI tumors were significantly more frequent in Muc (30.8%) than in WD (5.1%). CIN tumors were significantly less frequent in Muc (53.8%) than in WD (87.2%). In Muc, MSI tumors were significantly more frequent in the proximal colon (55.6%) than in the distal colon (9.5%). Also, methylation of the hMLH1 promoter region in Muc was significantly more frequent in MSI tumors (83.3%) than in CIN tumors (27.8%) (P = 0.0077).CONCLUSIONSWhen matched for T classification and tumor location, Muc shows higher rates of MSI and lower rates of CIN than WD.. Muc shows different characteristics according to tumor location, and methylation of the hMLH1 promoter region strongly correlates with Muc tumors showing MSI. Cancer 2005. © 2005 American Cancer Society.

show abstract

Clinicopathological characteristics of mucinous carcinoma of the colon and rectum

Abstract: As colorectal MCs proliferate and metastasize more rapidly than do NMCs, surgeons should realize that more aggressive surgical treatment should be occasionally administered to improve the postoperative prognosis of the patients with colorectal MCs.

Cited by 156 publications

References 25 publications

Clinical significance of signet-ring cells in colorectal mucinous adenocarcinoma

Clinical significance of signet-ring cells in colorectal mucinous adenocarcinoma

Mucinous carcinoma of the rectum: a distinct clinicopathological entity

Mucinous carcinomas of the colon and rectum show higher rates of microsatellite instability and lower rates of chromosomal instability

Contact Info

Product

Resources

About