Clinicopathological characteristics of mucinous carcinoma of the colon and rectum

Nozoe, Tetsuo; Anai, Hideaki; Nasu, Shinji; Sugimachi, Keizō

doi:10.1002/1096-9098(200010)75:2<103::aid-jso6>3.3.co;2-3

Cited by 25 publications

(37 citation statements)

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“…Moreover, mucinous adenocarcinomas tended to occur at higher AJCC/UICC stage, although this association lacked statistical significance. Confirming our data, several studies have observed mucinous adenocarcinomas to occur more frequently within the right hemicolon, 15,18,19,21,30,38 with larger tumour size 15,16,39 and with higher stage at time of diagnosis 13,16,18,21,38,40 . Umpleby et al.…”

Section: Discussionsupporting

confidence: 90%

“…Previous studies have reported mucinous adenocarcinomas to show a greater propensity for early spread to regional lymph nodes 8,15,18,21 as well as to the peritoneum 15,16 . Despite abundant body of reports correlating mucinous histology with patients’ outcome, data remain controversial and the biological significance of mucinous differentiation in CRC still needs to be defined.…”

Section: Discussionmentioning

confidence: 99%

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Mucinous differentiation in colorectal cancer – indicator of poor prognosis?

et al. 2012

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Langner C, Harbaum L, Pollheimer M J, Kornprat P, Lindtner R A, Schlemmer A, Vieth M & Rehak P  (2012) Histopathology 60, 1060–1072 Mucinous differentiation in colorectal cancer – indicator of poor prognosis? Aims: To analyse the prognostic impact of mucinous differentiation in colorectal mucinous adenocarcinomas and adenocarcinomas with a mucinous component. Methods and results: A total of 381 tumours were reviewed for mucinous differentiation by two independent pathologists. Mismatch repair status was assessed by immunohistochemistry. Prognostic significance was assessed by univariate and multivariate analyses. Eighty‐one (21%) tumours were Union Internationale Contre le Cancer (UICC) Stage I, 120 (31%) Stage II, 126 (33%) Stage III and 54 (14%) Stage IV. Mucinous adenocarcinomas accounted for 12% and adenocarcinomas with a mucinous component for 19% of tumours. Mucinous differentiation was associated significantly with mismatch repair protein deficiency. The presence of extracellular mucin, regardless of extent, did not affect patients’ outcome, while tumour grade, vascular and perineural invasion, tumour border configuration and budding were associated significantly with outcome. Cox analysis proved venous invasion to be an independent predictor of outcome in mucinous adenocarcinomas and both venous invasion and tumour budding as independent predictors of outcome in adenocarcinomas with any amount of mucin. Conclusions: Mucinous adenocarcinomas and/or adenocarcinomas with mucinous component do not differ from conventional adenocarcinomas with respect to prognosis and histological predictors of outcome. Hence, recording of mucinous differentiation may be used as an indicator of mismatch repair deficiency, but not for prognostic stratification.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Mucinous differentiation in colorectal cancer – indicator of poor prognosis?

et al. 2012

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“…Nodal metastases are also associated with the presence of peritoneal carcinomatosis because lymph node involvement is commonly observed in advanced tumors (higher T stage) [12,13,15]. Histopathological factors of the tumor including mucinous histology [16][17][18] and the presence of signet ring morphology [17,19] have also been shown to be associated with peritoneal carcinomatosis. Clinically, tumors that present with obstruction or perforation are associated with peritoneal carcinomatosis due to the high risk of peritoneal dissemination both because of the extensive growth pattern and the result of surgery that often result in tumor soilage in the peritoneal cavity [20,21].…”

Section: Risk Factors For Peritoneal Carcinomatosiscontrasting

confidence: 42%

Surgery for colorectal peritoneal carcinomatosis

Chua

Pelz

Morris

2012

Scandinavian Journal of Gastroenterology

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Peritoneal carcinomatosis occurs in patients with advanced gastrointestinal and gynecological malignancies and also in patients who experience recurrence after treatment failure of the primary tumor. Malignant disease in the peritoneal cavity is a morbid and significant predictor of a diminished survival in a cancer patient. Systemic chemotherapy alone will not be adequate to palliate or treat patients with peritoneal carcinomatosis. Cytoreductive surgery is a new surgical technique that is performed using peritonectomy procedures to allow total eradication of peritoneal tumors. Intraperitoneal chemotherapy regimens such as intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC) and early postoperative intraperitoneal chemotherapy (EPIC) are effective adjuvant treatment to treat the minimal residual disease after cytoreductive surgery to reduce the risk of locoregional recurrence. A substantial body of evidence available in the current literature has documented the survival benefits of combining cytoreductive surgery and intraperitoneal chemotherapy to treat a previously fatal phase of malignancy. This review provides a summary of the developments in the understanding and treatment of peritoneal surface malignancy from colorectal cancer.

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“…Although we have stated that the difference in prognosis should arise from the biological behavior [1], we are strongly impressed by the excellent results in patients with colorectal mucinous carcinoma treated by intraperitoneal chemotherapy wash [2,3].…”

Section: Replymentioning

confidence: 99%

“…Dear Sir, I read with great interest the article by Nozoe and colleagues [1] entitled,``Clinicopathological Characteristics of Mucinous Carcinoma of the Colon and Rectum.'' They compared 18 patients (6.3%) with mucinous carcinoma to 265 patients with nonmucinous carcinomas.…”

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confidence: 99%

Mucinous colorectal carcinoma

Sugarbaker¹

2001

Journal of Surgical Oncology

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Clinicopathological characteristics of mucinous carcinoma of the colon and rectum

Cited by 25 publications

References 0 publications

Mucinous differentiation in colorectal cancer – indicator of poor prognosis?

Mucinous differentiation in colorectal cancer – indicator of poor prognosis?

Surgery for colorectal peritoneal carcinomatosis

Mucinous colorectal carcinoma

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