Clinicopathological characteristics of mammary Paget’s disease: A single‐center 25‐year experience in Korea

Kim, Young Jae; Lee, Keon H; Lee, Woo J; Won, Chong Hyun; Chang, Sung Eun; Choi, Jee Ho; Lee, Mi W

doi:10.1111/tbj.13651

Cited by 4 publications

(7 citation statements)

References 7 publications

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“…In our study, the prevalence of MPD in females was significantly lower than that in South Korea, which reported a prevalence of 0.091% between 1995 and 2019 25 . However, the hospital-based design in South Korea study could contribute to this evident discrepancy.…”

Section: Discussioncontrasting

confidence: 72%

“…The relatively longer life expectancy in these developed western countries might have an impact on this difference 35 . However, racial disparity might also play a role, considering that patients with MPD in other Asian areas including the South Korea, Iran, Turkey, Saudi Arabia, Thailand and Taiwan of China were also much younger than those in Western populations [12][13][14][16][17][18]25,36 . A similar age discrepancy was observed in breast cancer between Chinese women and women from Western countries 28 .…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of mammary Paget’s disease in urban China in 2016

Yin

Wang

et al. 2021

Sci Rep

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No national data have been available on descriptive epidemiology of mammary Paget’s disease (MPD) in China. This population-based study aimed to estimate the prevalence of MPD and its pattens by sex, age and area in China. We conducted a population-based study using data in 2016 from China’s Urban Employee Basic Medical Insurance and Urban Resident Basic Medical Insurance, covering approximately 0.43 billion residents. MPD cases were identified based on the diagnostic names and codes in claim data. A total of 825 patients of confirmed diagnosis of MPD were found during the study period. The prevalence of MPD in 2016 was 0.42 per 100,000 population (95% CI 0.19 to 0.73), with marked female predominance. The prevalence rates peaked at 40–59 years and ≥ 80 years in females and males, respectively. The prevalence rates varied among different regions, ranging from 0.06 (95% CI 0.00 to 0.23) in Northeast China to 1.21 (95% CI 0.07 to 3.72) in Northwest China. MPD showed marked female predominance in China. Chinese female patients were much younger, with lower prevalence than that in the United States. Obvious sex difference in the age pattern of MPD prevalence was also observed in China.

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Section: Discussioncontrasting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Prevalence of mammary Paget’s disease in urban China in 2016

Yin

Wang

et al. 2021

Sci Rep

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“…In univariate analysis, tumor type was the only significant parameter affecting the OS. Like the previous studies, IDC was found to be associated with poor prognosis [6,18,22]. Müjgan et al found that cancer specific survival was significantly worse for patients with invasive disease [4].…”

Section: Discussionmentioning

confidence: 63%

“…Paget’s disease is frequently encountered in females, in the 5th–6th decades of life [ 3 , 8 , 10 , 18 ]. In our study, the mean age was 53.5 years.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological features of mammary Paget’s disease: a single-center experience in Turkey

Kar¹,

Altindag²,

Etıt³

et al. 2021

Turk J Med Sci

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Background/aim: Paget's disease (PD) of the breast is a very rare presentation of breast malignancy, accounting for 1-3% of all primary breast tumors. We aimed to evaluate and compare the clinicopathological featuresand clinical outcome of PD accompanied by in situ carcinoma and invasive cancer. Materials and Methods:We used the archive of our pathology laboratory retrospectively for age, gender, history of surgery, histopathological findings, treatment modalities and follow-up information. We used the Kaplan-Meier method for survival analysis.Results: There were 46 female patients diagnosed with PD. In 39 (84.7%) patients invasive carcinoma accompanied PD, while 7 (15.3%) patients had ductal carcinoma in situ (DCIS).The median age at diagnosis was 53.5 years. The median follow-up period was 47 months. Of the 39 invasive carcinoma 10 (25.6%) died during the follow-up period. Invasive ductal carcinoma group had a mean overall survival of rate of 57.8 ± 6.6 months. According to univariate analysis only the tumor type was found to impact overall survival (p < 0.001) Conclusions:The current study displayed the tumor type as the only parameter affecting overall survival in the invasive carcinoma group. Although it was not statistically significant, breast cancers accompanied by PD were found to be predominantly advanced stage tumors, high grade, hormon receptor negative and HER2 positive.

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“… 1 - 4 It is observed in 0.5% to 5% of cases of breast carcinoma, 5 , 6 , and the prevalence of MPD was 0.091% in skin biopsy slides. 7 The median (range) age was 60 (20-90) years, 8 mainly occurring in patients over the age of 40, and is rarely found in young women. 9 The most common treatment is complete mastectomy and the 5-year overall survival rate of patients with MPD is greater than 80% but is lower among older and black people.…”

Section: Introductionmentioning

confidence: 99%

Mammary Paget’s Disease of Young Females: Case Reports and Comparison With Middle-Aged and Elderly Patients

Cheng

Guo

et al. 2023

Clin Med�Insights�Pathol

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Purpose: Mammary Paget’s disease (PD) in young women has seldom been reported. The aim of this study was to improve the knowledge of the clinicopathological characteristics in young patients with PD to provide a basis for the precise treatment of young patients. Methods: The medical records and pathological slides of 8 young patients (younger than 40 years old) with PD were reviewed. The data of 20 patients over 40 years old within the same period were used as controls. Results: The average age was 32.00 ± 3.96 years for the young patient group, with the youngest aged 27 years. The first symptom, physical examination, Paget cell morphology, and immunohistochemical marks were the same in different age groups. But young patients have varied tumor distribution patterns, fewer interstitial inflammatory cells, and advanced pathological local lymphatic metastasis than older patients in the same period. Conclusions: PD in young women has unique histopathological features. These manifestations seem to provide personalized treatment for PD treatment in young patients. More research is needed to clarify the significance of this research.

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Clinicopathological characteristics of mammary Paget’s disease: A single‐center 25‐year experience in Korea

Cited by 4 publications

References 7 publications

Prevalence of mammary Paget’s disease in urban China in 2016

Prevalence of mammary Paget’s disease in urban China in 2016

Clinicopathological features of mammary Paget’s disease: a single-center experience in Turkey

Mammary Paget’s Disease of Young Females: Case Reports and Comparison With Middle-Aged and Elderly Patients

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