Clinicopathological Characteristics and Survival Outcomes of Primary Hepatic Neuroendocrine Tumor: A Surveillance, Epidemiology, and End Results (SEER) Population-Based Study

Li, Yufeng; Zhang, Qiuqiang; Wang, Weilin

doi:10.12659/msm.923375

Cited by 15 publications

(15 citation statements)

References 28 publications

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“…Currently, there is no uniform treatment guideline for PHNETs, but surgical resection is the best treatment option for resectable lesions. Li et al reported that the 5-year survival rates were 71.9% and 15.6%, respectively, in the analysis of 291 patients, with or without undergoing surgery [13] . The study by Givi et al showed that the median survival time for patients who underwent surgery was approximately 159 months, compared to only 47 months for those who did not [14] .…”

Section: Discussionmentioning

confidence: 99%

Primary hepatic neuroendocrine carcinoma with colon adenoma: A case report with literature review

Wang

Zhang

Liu

et al. 2022

International Journal of Surgery Case Reports

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Section: Discussionmentioning

confidence: 99%

Primary hepatic neuroendocrine carcinoma with colon adenoma: A case report with literature review

Wang

Zhang

Liu

et al. 2022

International Journal of Surgery Case Reports

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“…PHNET is a rare NET entity arising from Kulchitsky cells originating from the neural crest[ 2 ]. The total number of PHNET cases reported in the English literature is less than 200[ 5 ]. Due to its rarity, the clinical features and image findings are not well understood.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have shown that tumor markers such as alpha-fetoprotein, carcinoembryonic antigen, and CA 19-9 have no diagnostic value for PHNET[ 5 ]. Imaging examinations, such as ultrasound, CT, and magnetic resonance imaging, also have low sensitivity and specificity for PHNET.…”

Section: Discussionmentioning

confidence: 99%

Primary hepatic neuroendocrine tumor — ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography findings: A case report

Rao¹,

Zhang²,

Wang³

et al. 2021

WJCC

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BACKGROUND Primary hepatic neuroendocrine tumors (PHNETs) are rare hepatic tumors. Their diagnosis, which is based on radiological findings, is difficult. CASE SUMMARY We present a case of PHNET in a 79-year-old man with no clinical symptoms. Computed tomography (CT) and 2-Deoxy-2-[fluorine-18] fluorodeoxyglucose positron emission tomography/CT ( 18 F-FDG PET/CT) were performed for further evaluation. A hypoattenuating mass with rim-like enhancement in segment 6 of the liver was detected on contrast-enhanced CT imaging. Increased uptake was also observed on 18 F-FDG PET/CT. Histopathological and immunohistochemical examinations, which revealed a grade 2 neuroendocrine tumor (NET), confirmed the diagnosis. CONCLUSION Diagnosing PHNET is challenging, and must be distinguished from other liver tumors. Metastatic NETs should be excluded.

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“…The lower cellular proliferation grades (G1/G2) were demonstrated as a favorable prognostic factor for PHNET. 9,14 In addition, previous reports showed a tendency that the older patients presented with a higher tumor grade.…”

Section: Although Preoperative Blood Tests and Tumor Marker Testsmentioning

confidence: 94%

Primary Hepatic Neuroendocrine Tumor Arising at a Young Age: Rare Case Report and Literature Review

SONG

Koh

2022

Korean J Gastroenterol

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Neuroendocrine tumors (NETs) are low-grade malignancies arising from neuroendocrine cells. Primary hepatic neuroendocrine tumors (PHNETs) are extremely rare and difficult to differentiate from other liver tumors, such as hepatocellular carcinoma (HCC) or cholangiocarcinoma. A 22-year-old male presented with intermittent abdominal pain. A preoperative imaging study revealed a 5.1cm-sized heterogeneously enhancing mass in S6 of the liver, suggesting HCC. Laparoscopic right hepatectomy was performed, and a well-demarcated brown solid mass was found. The pathology report revealed a neuroendocrine tumor of the liver. 18F-fluorodeoxyglucose-positron emission tomography/computed tomography was performed postoperatively to exclude extrahepatic lesions, and no lesions were found. This is a rare case of PHNET that developed at a young age and was misdiagnosed as HCC preoperatively. This suggests that PHNET should be considered one of the differential diagnoses when a non-specific enhanced hepatic tumor is found, even when the patient is young.

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Clinicopathological Characteristics and Survival Outcomes of Primary Hepatic Neuroendocrine Tumor: A Surveillance, Epidemiology, and End Results (SEER) Population-Based Study

Cited by 15 publications

References 28 publications

Primary hepatic neuroendocrine carcinoma with colon adenoma: A case report with literature review

Primary hepatic neuroendocrine carcinoma with colon adenoma: A case report with literature review

Primary hepatic neuroendocrine tumor — ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography findings: A case report

Primary Hepatic Neuroendocrine Tumor Arising at a Young Age: Rare Case Report and Literature Review

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Clinicopathological Characteristics and Survival Outcomes of Primary Hepatic Neuroendocrine Tumor: A Surveillance, Epidemiology, and End Results (SEER) Population-Based Study

Cited by 15 publications

References 28 publications

Primary hepatic neuroendocrine carcinoma with colon adenoma: A case report with literature review

Primary hepatic neuroendocrine carcinoma with colon adenoma: A case report with literature review

Primary hepatic neuroendocrine tumor — 18F-fluorodeoxyglucose positron emission tomography/computed tomography findings: A case report

Primary Hepatic Neuroendocrine Tumor Arising at a Young Age: Rare Case Report and Literature Review

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Primary hepatic neuroendocrine tumor — ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography findings: A case report