Clinicopathological Characteristics and Prognostic Prediction in Pseudomyxoma Peritonei Originating From Mucinous Ovarian Cancer

Fu, Fengxian; Ma, Xulan; Lu, Yiyan; Xu, Hongbin; Ma, Ruiqing

doi:10.3389/fonc.2021.641053

Cited by 5 publications

(7 citation statements)

References 23 publications

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“…Patients with low-grade mucinous cancers and those with lower peritoneal cancer index scores had improved overall survival. Notably, median overall survival times were shorter than 40 months for the entire cohort of patients with pseudomyxoma peritonei due to mucinous ovarian cancer in this study 56…”

Section: Systemic Treatmentmentioning

confidence: 59%

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Primary mucinous ovarian cancer: options for surgery and chemotherapy

Kurnit

Frumovitz

2022

Int J Gynecol Cancer

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Primary mucinous ovarian cancer is a rare type of epithelial ovarian cancer. In this comprehensive review we discuss management recommendations for the treatment of mucinous ovarian cancer. Although most tumors are stage I at diagnosis, 15–20% are advanced stage at diagnosis. Traditionally, patients with primary mucinous ovarian cancer have been treated similarly to those with the more common serous ovarian cancer. However, recent studies have shown that mucinous ovarian cancer is very different from other types of epithelial ovarian cancer. Primary mucinous ovarian cancer is less likely to spread to lymph nodes or the upper abdomen and more likely to affect younger women, who may desire fertility-sparing therapies. Surgical management of mucinous ovarian cancer mirrors surgical management of other types of epithelial ovarian cancer and includes a bilateral salpingo-oophorectomy and total hysterectomy. When staging is indicated, it should include pelvic washing, omentectomy, and peritoneal biopsies; lymph node evaluation should be considered in patients with infiltrative tumors. The appendix should be routinely evaluated intra-operatively, but an appendectomy may be omitted if the appendix appears grossly normal. Fertility preservation can be considered in patients with gross disease confined to one ovary and a normal-appearing contralateral ovary. Patients with recurrent platinum-sensitive disease whose disease distribution suggests a high likelihood of complete gross resection may be candidates for secondary debulking. Primary mucinous ovarian cancer seems to be resistant to standard platinum-and-taxane regimens used frequently for other types of ovarian cancer. Gastrointestinal cancer regimens are another option; these include 5-fluorouracil and oxaliplatin, or capecitabine and oxaliplatin. Data on heated intra-peritoneal chemotherapy (HIPEC) for mucinous ovarian cancer are scarce, but HIPEC may be worth considering. For patients with recurrence or progression on first-line chemotherapy, we advocate enrollment in a clinical trial if one is available. For this reason, it may be beneficial to perform molecular testing in all patients with recurrent or progressive mucinous ovarian cancer.

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Section: Systemic Treatmentmentioning

confidence: 59%

“…51 A group from China published their experience with patients diagnosed with pseudomyxoma peritonei secondary to mucinous ovarian cancer. 56 Over a 10-year period they performed cytoreduction and HIPEC in 22 patients. Similar to van Driel et al, this group used cisplatin for perfusion.…”

Section: Systemic Treatment Primary Treatmentmentioning

confidence: 99%

Primary mucinous ovarian cancer: options for surgery and chemotherapy

Kurnit

Frumovitz

2022

Int J Gynecol Cancer

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“…We scored the prior surgical outcomes with PSS for each patient; PSS-0 was the rating for no surgery or biopsy, PSS-1 for surgery in one abdominal region only, PSS-2 for surgery in two to five regions, and PSS-3 for surgery in more than five regions 5 . A recent report showed that the univariate analysis of poor prognosis in patients with peritoneal pseudomyxoma after neoplasm reduction included women (P = 0.0127), intestinal obstruction before treatment (P = 0.00791) and PSS (P = 0.0054).…”

Section: Discussionmentioning

confidence: 99%

“…We obtained cutoff values based on objective data for gender, intestinal obstruction, weight loss, PSS, RBC, Hb, ALB, right hemicolectomy and HIPEC, among which the cutoff values for Hb and ALB were based on the lower limit of the normal reference range. The cutoff values of age, PCI, and CCR were obtained according to the previous grouping of our research center [5][6][7][8] . Due to the wide range of hospitalization days, we selected one month as the cutoff value.…”

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confidence: 99%

Prognostic prediction of preoperative nutritional status in low-grade appendiceal mucinous neoplasms

Wang

Shi

et al. 2022

Sci Rep

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To describe the preoperative nutritional status of Low-grade Appendiceal Mucinous Neoplasms (LAMNs) and identify prognostic factors for survival. Medical records from 165 patients with LAMNs who attended the Aerospace Center Hospital, Beijing, China between January 2017, and December 2018 were retrospectively reviewed. Survival analysis was performed with the Kaplan–Meier method, the log-rank test, and a Cox proportional hazards model. Among 165 patients, 59 (36%) were male and 106 (64%) were female. Patient’s median age was 58 years (range 20 to 78 years). Univariate analysis indicated that gender, weight loss, prior surgical score (PSS), red blood cell, albumin, peritoneal cancer index (PCI), completeness of cytoreduction (CCR), and hyperthermic intraperitoneal chemotherapy (HIPEC) were related to prognosis. Multivariate analysis showed that PSS, CCR and HIPEC were independent predictors of prognosis. The preoperative nutritional status of patients plays an important role in predicting prognosis. Patients can benefit from a complete cytoreductive surgery (CCRS) and HIPEC in an experienced institution for the first medical treatment.

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“…Oncological adequacy of surgery requires monoblock removal of the tumor-affected organ and resection of the blood vessel, followed by its reconstruction [7]. It should be recognized that the performance of operations related to resection, as well as one or another type of vascular plasticity in pelvic extraorgan tumors, can only afford large, technically equipped surgical centers with qualified surgical personnel [6].…”

Section: загальна та невідкла дна хірургіяmentioning

confidence: 99%

Surgical Treatment of Patients With Extraorganic Tumors of the Pelvic Localization With Invasion of the Iliac Vessels

Kryvorotko¹,

Chykin²,

Tymchenko³

et al. 2021

Khark. Surg. Sch.

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The aim of our study was to determine the indications for expanding the scope of operations in patients with pelvic extraorgan local formations. Materials and methods. The results of surgical treatment of 7 patients with nonorgan tumors of the pelvic localization, who underwent resection on the main vessels in connection with their involvement in the tumor process, are presented. Results and discussion. A total of 7 interventions were performed on the iliac arteries — 2 resections with an end-to-end anastomosis and 5 prostheses (one case — the aorta resection with reconstruction with a bifurcation prosthesis). Patients with pelvic extraorgan tumors are a special cohort of patients, due to the presence of several organs in a narrow space, which inevitably causes them to fit snugly to the tumor. Locally advanced tumor process in extraorganic tumors involving the main vessels of the pelvis and adjacent organs is not a reason to refuse surgery, and despite the complications, repeated recurrences and previous operations, are well tolerated by patients. This is especially important due to the lack of a real alternative to surgical treatment of this group of patients. Conclusions. Surgical intervention in the treatment of pelvic inorganic tumors involving the main vessels is the only radical method of treatment. Invasion of the main arterial and venous vessels is not a contraindication to surgery in patients with pelvic tumors. Combined angioplastic interventions allow to achieve a long without recurrent period even after cytoreductive operations.

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Clinicopathological Characteristics and Prognostic Prediction in Pseudomyxoma Peritonei Originating From Mucinous Ovarian Cancer

Cited by 5 publications

References 23 publications

Primary mucinous ovarian cancer: options for surgery and chemotherapy

Primary mucinous ovarian cancer: options for surgery and chemotherapy

Prognostic prediction of preoperative nutritional status in low-grade appendiceal mucinous neoplasms

Surgical Treatment of Patients With Extraorganic Tumors of the Pelvic Localization With Invasion of the Iliac Vessels

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