Clinicopathological Characteristics and Prognosis of Hepatoid Adenocarcinoma of the Stomach: Evaluation of a Pooled Case Series

Zeng, Xiangyu; Yin, Yuping; Xiao, Hua; Zhang, Peng; He, Jun; Liu, Weizhen; Gao, Jinbo; Shuai, Xiaoming; Wang, Guobin; Wu, Xiaoyin; Tao, Kaixiong

doi:10.1007/s11596-018-1983-1

Cited by 40 publications

(55 citation statements)

References 44 publications

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“…Another study found that the interval between gastrectomy and liver metastases in patients with HAS is shorter than CGC, resulting in a poorer prognosis [8]. Baek [16]. The median OS of the patients in this study was 28 months.…”

Section: Discussionmentioning

confidence: 54%

“…Su et al reported an elevated serum AFP level in 84.8% of patients with HAS, ranging from 1.0 to 475,000 ng/mL [1]. Another study reported that about 80.6% of patients with HAS had elevated serum AFP levels [16]. Of the 31 patients in this study, 27 had serum AFP levels detected at the time of diagnosis, and 81.5% (22/27) patients had elevated serum AFP levels, of which 26.0% (7/27) patients had higher serum AFP levels than the instrument measurable upper limit.…”

Section: Discussionmentioning

confidence: 97%

“…However, compared with CGC, the radical resection of HAS is more challenging because of its higher incidence of vascular invasion, lymph node metastasis and distant metastasis before surgery. Radical surgery, early pTNM and adjuvant therapy can signi cantly improve the prognosis of HAS [16]. One study described several different treatment options that can delay the progression of HAS, including cisplatin plus uorouracil and epirubicin or irinotecan combined with mitomycin C [23].…”

Section: Discussionmentioning

confidence: 99%

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Clinicopathological and Prognostic Characteristics of Hepatoid Adenocarcinoma of the Stomach

Liu

Qin

Chang

et al. 2020

Preprint

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Objectives The aim of this study is to analyze the clinical and pathological features of HAS and investigate the factors affecting prognosis.Methods From January 2014 to May 2020, 31 patients were diagnosed as HAS in in the First Affiliated Hospital of Zhengzhou University. The clinicopathologic features and the relevant prognosis of these patients were analyzed.Results Of the 31 patients, 23 were male, with a median age of 62 years. And among the 31 patients, 22 patients underwent a radical gastrectomy and a D2 lymph node dissection. During the follow up period, 18 patients died of the disease. The median OS (mOS) was 28 months. The 1-year survival rate was 55%, the 3-year survival rate was 47%, and the 5-year survival rate was 34%. An elevated CA125 level, distant metastasis, and radical surgery were associated with the prognosis of HAS, and distant metastasis is an independent prognostic risk factor for survival. Conclusion HAS had a poor prognosis because of its frequent vascular involvement, and lymph node and liver metastasis. Aggressive multimodal treatment comprising radical gastrectomy and adjuvant chemotherapy is warranted.This article describes the Clinicopathological of Hepatoid Adenocarcinoma of the Stomach and through survival analysis, the factors affecting the patient’s prognosis were studied.

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

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Clinicopathological and Prognostic Characteristics of Hepatoid Adenocarcinoma of the Stomach

Liu

Qin

Chang

et al. 2020

Preprint

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“…of the patients. The median tumor diameter was 5.5 cm (23) . Adachi et al found a 5-year survival rate of 22% in all patients and a median survival time of 14 months, in their Japanese literature series involving 270 cases (24) .…”

Section: Discussionmentioning

confidence: 99%

Review of the Clinicopathological Features and Prognosis of the Rare Histological Types of Gastric Cancer

Talih¹,

Topal²,

Sözüer³

et al. 2020

BMJ

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Objective: Gastric cancer consists of many histological subtypes. Prognostic value of histological types in gastric cancer has not been very well defined. In this study, we aimed to investigate the relationship between different histological types and clinicopathologic features and prognosis in gastric cancer. Method: Patients whose pathological diagnosis was adenosquamous carcinoma, hepatoid adenocarcinoma, lymphoepithelioma-like carcinoma, and papillary adenocarcinoma, among the 1060 patients who underwent gastrectomy for gastric cancer between 2010-2019, were included in the study. Demographic features, clinicopathological features, oncological follow-up results and survival of the patients were analyzed. Results: Group 1 (adenosquamous carcinoma) consisted of 3, Group 2 (hepatoid adenocarcinoma) of 3, Group 3 (lymphoepithelioma-like carcinoma) of 3, and Group 4 (papillary adenocarcinoma) consisted of 4 patients. The mean age of the patients included in the study was 63.3+11.76 (41-81) years. Tumors were more commonly located in the corpus in hepatoid adenocarcinoma and lymphoma-like carcinoma (67%) and in the antrum (75%) in papillary adenocarcinoma. Eight patients underwent total gastrectomy, four patients subtotal gastrectomy, and a patient with a tumor located at the gastroesophageal junction underwent proximal gastrectomy. Average tumor size (cm) was 5.11+2.23 (1.2-8) cm. Local recurrence occurred in two patients with adenosquamous carcinoma, two with hepatoid adenocarcinoma, and one with papillary adenocarcinoma. Two patients with adenosquamous carcinoma developed systemic metastasis (lung, liver), two patients with hepatoid adenocarcinoma developed peritoneal carcinomatosis, and a patient with papillary adenocarcinoma developed surrenal metastasis. Average survival was the shortest in hepatoid adenocarcinoma (17.50 months), and the longest in papillary adenocarcinoma (63 months). There was no statistical difference in survival between the groups (p: 0.445). Conclusion: Rare histological types of the stomach differed in terms of their locations and prognoses. Among the rare histological types, hepatoid adenocarcinoma exhibited the most aggressive biological behavior, while patients with papillary adenocarcinoma had longer survival times.

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“…The gastroscopy biopsy and (or) surgical specimens of HAS both have different percentages of HAS cell components. Once the pre-operative and postoperative specimens were found with adenocarcinoma, hepatocellular carcinoma or the sole hepatocyte-like regions in morphology, which would be added to examine several immune-histochemical markers, such as AFP [21], Glypican-3(GPC-3), SALL4 and Hap-Par 1 [7,22]. If the immunohistochemical marker AFP was positive, we preliminarily considered the diagnosis of a patient's disease as HAS.…”

Section: The Diagnose Of Patientsmentioning

confidence: 99%

The prognosis of hepatoid adenocarcinoma of the stomach: a propensity score-based analysis

Zhou

Wang

et al. 2020

Preprint

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Background : To investigate whether there is a distinct difference in prognosis between hepatoid adenocarcinoma of the stomach ( HAS) and non-hepatoid adenocarcinoma of the stomach (non-HAS) and whether HAS can benefit from radical surgery. Methods : We retrospectively reviewed 722 patients with non-HAS and 75 patients with HAS who underwent radical gastrectomy between 3 November 2009 and 17 December 2018. Propensity score matching (PSM) analysis was used to eliminate the bias among the patients in our study. The relationships between gastric cancer type and overall survival (OS) were evaluated by the Kaplan-Meier method and Cox regression. Results : Our data demonstrate that there was no statistically significant difference in the OS between HAS and non-HAS {K-M, P=log rank (Mantel-Cox), (before PSM P=0.397); (1:1 PSM P=0.345); (1:2 PSM P=0.195)}. Moreover, there were no significant differences in the 1-, 2-, or 3-year survival rates between patients with non-HAS and patients with HAS (before propensity matching, after 1:1 propensity matching, and after 1:2 propensity matching). Conclusion : HAS was generally considered to be an aggressive gastric neoplasm, but its prognosis may not be as unsatisfactory as previously believed.

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Clinicopathological Characteristics and Prognosis of Hepatoid Adenocarcinoma of the Stomach: Evaluation of a Pooled Case Series

Cited by 40 publications

References 44 publications

Clinicopathological and Prognostic Characteristics of Hepatoid Adenocarcinoma of the Stomach

Clinicopathological and Prognostic Characteristics of Hepatoid Adenocarcinoma of the Stomach

Review of the Clinicopathological Features and Prognosis of the Rare Histological Types of Gastric Cancer

The prognosis of hepatoid adenocarcinoma of the stomach: a propensity score-based analysis

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