Clinicopathological Characteristics and Prognosis of Squamous Cell Carcinoma of the Breast: A Population-Based Analysis

Wang, Jiayu; Wang, Zijing; Xu, Binghe

doi:10.1177/10732748211044355

Cited by 4 publications

(4 citation statements)

References 15 publications

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“…The inconsistent results regarding the above treatment methods indicate the need to examine more cases of ASCC. 19,20 Given the irreversible nature of the mass in the current case, we administered neoadjuvant therapy with albumin-paclitaxel, carboplatin, and trastuzumab, with excellent results, confirming the efficacy of this treatment for HER2-positive SCC. Postoperative pathology suggested that there was some residual carcinoma in situ in the lesion, ER and PR were highly expressed, and that the addition of anastrozole could reduce the risk of recurrence and metastasis.…”

Section: Discussionsupporting

confidence: 56%

Neoadjuvant therapy for HER2-positive acantholytic squamous cell breast carcinoma: a case report

Cong¹,

Zou³

et al. 2023

J Int Med Res

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HER2-positive acantholytic squamous cell carcinoma (ASCC) of the breast is exceptionally rare, and its clinicopathologic features are poorly understood. The impact of neoadjuvant therapy on HER2-positive breast ASCC is unclear. Here we report on a 58-year-old woman who was diagnosed with HER2-positive ASCC of the right breast, who underwent neoadjuvant treatment with albumin-paclitaxel, carboplatin, and trastuzumab, and surgery. Neoadjuvant therapy was effective, with no recurrence or metastasis after 1.5 years of postoperative follow-up.

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Section: Discussionsupporting

confidence: 56%

Neoadjuvant therapy for HER2-positive acantholytic squamous cell breast carcinoma: a case report

Cong¹,

Zou³

et al. 2023

J Int Med Res

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“…Central cystic degeneration is common in tumors larger than 2 cm, and this cavity is filled with necrotic squamous debris (4). Tumors with diffuse keratinization are macroscopically softer and granular in appearance (10).…”

Section: Discussionmentioning

confidence: 99%

“…Because it was reported in our patient who had an ulcerated skin lesion, the pathological examination revealed that the tumor had no cutaneous origin and developed primarily from the breast. When establishing a definitive diagnosis of primary squamous cell carcinoma of the breast, it may be possible after exclusion of metastasis from an extramammary primary squamous cell carcinoma, such as carcinomas of the lung, uterine cervix, bladder, and head and neck region (10). It is important to distinguish between Primary or Metastatic Squamous Cell Carcinoma because treatment protocols are very different.…”

Section: Discussionmentioning

confidence: 99%

Primary Squamous Cell Carcinoma of the Breast. A Case Report with Review of the Literature

Esmer

Dağ

2023

Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi

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Primary squamous-cell carcinoma of the breast is a rare entity classified under the metaplastic carcinomas of the breast. The prognosis is poor, and there is no consensus for clinical treatment that is multi-modal treatment options of surgery, chemotherapy, and radiation therapy. In our case, all the locations that can develop squamous-cell carcinoma were scanned, and no tumors were found in these foci. Histopathological examination of our case matched the verrucous carcinoma variant of primary squamous-cell carcinoma of the breast. We presented 30-year-old female primary squamous-cell carcinoma of the left breast due to a rare clinical entity, and the recent literature is reviewed and presented.

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“…Metaplastic carcinomas account for approximately 0.2—1% of all invasive breast cancers [ 1 ]. Squamous cell carcinoma (SCC) of the breast is a rare type of metaplastic cancer that accounts for approximately 0.1% of all invasive malignancies [ 2 ]. Owing to its extremely low prevalence, there is limited knowledge about its clinical presentation and lack of standardized treatment for SCC of the breast [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Primary squamous cell carcinoma of the breast: a case report

Liu,

Chen,

Hou

2024

Discov Onc

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Introduction Squamous cell carcinoma (SCC) of the breast is a rare variant of invasive breast cancer that has been classified as metaplastic carcinoma. When a tumor is composed of spindle cells, diagnosis is challenging. Case report A 42-year-old woman with a large mass in the right breast underwent modified radical mastectomy. A pathological examination revealed a tumor with central necrosis in it. The tumor had a sarcomatoid growth pattern and the cells were spindle-shaped with severe atypicality. Immunohistochemical staining showed that P63, P53, vimentin, and CKpan were positive, whereas estrogen receptor and C-erbB-2 were negative. Ki-67 proliferation index was as high as 90%. Therefore, a diagnosis of SCC of the right breast was made. The patient received eight cycles of postoperative chemotherapy with paclitaxel and carboplatin, followed by seven cycles of radiotherapy. During follow-up, the patient also had a left thyroid tumor, and postoperative pathology suggested microinvasive follicular carcinoma. Since breast surgery, the patient has remained disease-free for more than four years. Conclusion SCC of the breast with spindle cell and sarcomatoid features is rare. The diagnosis of such tumors requires exclusion of tumors with similar histological morphologies.

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Clinicopathological Characteristics and Prognosis of Squamous Cell Carcinoma of the Breast: A Population-Based Analysis

Cited by 4 publications

References 15 publications

Neoadjuvant therapy for HER2-positive acantholytic squamous cell breast carcinoma: a case report

Neoadjuvant therapy for HER2-positive acantholytic squamous cell breast carcinoma: a case report

Primary Squamous Cell Carcinoma of the Breast. A Case Report with Review of the Literature

Primary squamous cell carcinoma of the breast: a case report

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