Clinicopathological characteristics and prognosis of metastatic collecting duct carcinoma

Zhou, Li; Liu, Yiqiang; Mo, Jiazhi; Cui, Chuanliang; Chen, Zhihong; Si, Lu; Kong, Yan; Yan, Xieqiao; Li, Siming; Wu, Xiaowen; Li, Juan; Xu, Huayan; Cao, Dengfeng; Guo, Jun; Sheng, Xinan

doi:10.1016/j.urolonc.2022.05.014

Cited by 2 publications

(2 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CDC has a high propensity for distant metastasis, with poor pathological differentiation and symptoms [ 4 , 5 ]. Many efforts, including advances in surgical techniques, radiotherapy, chemotherapy, targeted therapy, immunotherapy, and improvements in supportive treatment, have been made to increase the overall survival (OS) of patients with CDC [ 4 , 6 – 8 ].…”

Section: Introductionmentioning

confidence: 99%

Establishment of a nomogram to predict the overall survival of patients with collecting duct renal cell carcinoma

Jiang,

Zou,

Wen

2024

Discov Onc

View full text Add to dashboard Cite

Background Collecting duct carcinoma (CDC) is a rare histological type of renal cell carcinoma that lacks a prognostic prediction model. In this study, we developed a nomogram to predict the prognosis of CDC patients. Methods Data for patients (n = 247) diagnosed with CDC from 2004 to 2015 were obtained from the Surveillance, Epidemiology, and End Results (SEER) database, and the patients were randomized into training (n = 165) and validation (n = 82) cohorts. Survival outcomes were evaluated by the Kaplan–Meier method. Significant variables determined by univariate and multivariate Cox regression analyses were used to construct the nomogram. C-indexes and calibration plots were applied to evaluate the performance of the nomogram. Results CDC patients had a median overall survival (OS) of 18.0 months (95% confidence interval: 13.7–22.3); 1-year, 3-year, and 5-year OS rates were 58.7%, 34.2%, and 29.4%, respectively. Independent prognostic factors, including age at diagnosis, tumor size, tumor grade, T stage, N stage, M stage, and surgery information, were identified by multivariate analysis. The nomogram was constructed based on significant factors in the training cohort. The C-indexes were 0.769 (training cohort) and 0.767 (validation cohort). The calibration curves for survival rates showed that the predicted and observed values were consistent. Conclusions This study constructed a nomogram to predict prognosis in patients with CDC. The nomogram performed well in predicting the 1-year, 3-year, and 5-year OS, which can help doctors actively monitor and follow up patients.

show abstract

Section: Introductionmentioning

confidence: 99%

Establishment of a nomogram to predict the overall survival of patients with collecting duct renal cell carcinoma

Jiang,

Zou,

Wen

2024

Discov Onc

View full text Add to dashboard Cite

show abstract

“…To the best of our knowledge, only approximately 3 studies have been conducted on CDC with more than 20 cases in a single center. 8 , 11 , 12 Case reports and reviews are the main sources for improving our cognition of CDC. In this study, the clinical, imaging, pathologic characteristics, treatment, and prognostic outcomes of CDCs were retrospectively analyzed to provide insights into the disease.…”

Section: Introductionmentioning

confidence: 99%

Collecting Duct Carcinoma of the Kidney: A Single-Center Retrospective Study of 23 Cases

Tang

Chen

et al. 2023

Technol Cancer Res Treat

View full text Add to dashboard Cite

Objective: To explore the clinical, imaging, pathologic features, treatment, and prognostic outcomes in 23 cases of collecting duct carcinoma (CDC) from a single center. Methods: The clinical and imaging findings, pathological features, treatment methods, and outcomes of the 23 patients with CDC confirmed by microscopic examination between 2003 and 2020 at our institution were retrospectively reviewed. Descriptive statistics of demographic and clinical variables were applied. Kaplan–Meier method was used to analyze survival data and log-rank test statistic survival differences between groups. Cox regression analysis was employed to identify variables independently related to overall survival (OS). Results: A total of 23 patients with CDC were identified. The mean age was 50.8 years. Stage III or IV tumors were diagnosed in 82.6% of the patients at diagnosis. The average size of the tumor was 6.58 cm, and the left kidney was more involved than the right. The median OS was 12 months. The OS rates at 1 and 2 years were 43.5% and 26.1%, respectively. Twenty patients underwent nephrectomy, 3 underwent nephroureterectomy, and 9 (39.1%) patients received subsequent therapeutic interventions following surgery. Distant metastasis and no symptoms at initial diagnosis proved to be an independent factor of unfavorable survival in Cox regression analysis. Conclusions: CDC is a rare and highly aggressive malignant renal tumor, and most patients present at an advanced stage at initial diagnosis. More than half of the patients died within 1 year after surgery. Distant metastasis and no clinical symptoms at initial diagnosis were independent risk prognostic factors for patients with CDC.

show abstract

Clinicopathological characteristics and prognosis of metastatic collecting duct carcinoma

Cited by 2 publications

References 31 publications

Establishment of a nomogram to predict the overall survival of patients with collecting duct renal cell carcinoma

Establishment of a nomogram to predict the overall survival of patients with collecting duct renal cell carcinoma

Collecting Duct Carcinoma of the Kidney: A Single-Center Retrospective Study of 23 Cases

Contact Info

Product

Resources

About