Clinicopathological Characteristics and Prognosis in Endometrial Cancer With Bone Metastasis: A SEER-Based Study of 584 Women

Abstract

PurposeBone metastasis from endometrial cancer (EC) is rare and poorly described. The purpose of the present study was to investigate the correlation between the clinically accessible factors and survival time among EC patients with bone metastasis.Patients and MethodsWe retrospectively identified and reviewed EC patients with bone metastasis from 2010 to 2016, based on the Surveillance, Epidemiology and End Results (SEER) database. Univariable and multivariable Cox regressions were applied to evaluate the effects of clinical variables on survival. Kaplan–Meier plots were used to visually demonstrate the correlation between independent risk factors and survival.ResultsClinical data of 584 EC patients with bone metastasis from the SEER database were analyzed. EC patients with bone metastasis experienced extremely poor survival, with 1-year overall survival (OS) and cancer-specific survival (CSS) rates 33.8 and 35.8%, respectively. Variables associated with OS and CSS in the univariable analysis included race, tumor grade, tumor subtype, tumor size, lung, liver and brain metastases, surgery, radiotherapy, and chemotherapy. In the multivariable analysis, tumor grade, tumor subtype, liver and brain metastases, local surgery, and systemic chemotherapy remained independent risk factors for OS and CSS. However, local radiotherapy was an independent predictor of OS, not CSS.ConclusionsWe identified several factors affect the survival of EC patients with bone metastasis, which is useful for clinicians to assess patients’ outcomes. Our study supports surgery and radiotherapy of primary EC, and systemic chemotherapy for prolonging survival among EC patients with bone metastasis, which lays a solid foundation for defining optimal treatment strategy in this specific cohort.

Clinical Characteristics and Prognostic Factors of Endometrial Cancer Patients With Liver Metastasis: A Surveillance, Epidemiology, and End Results Database (SEER)-Based Study of 1,034 Women

“…The multivariate analyses in our study revealed that the non-endometrioid histological subtype emerged as an independent risk factor for lower OS within our study cohort. This finding aligns with the conclusions drawn by Liu et al and Hu et al [6,7], supporting the notion that the non-endometrioid subtype is characterized by more aggressive biological behavior and limited responsiveness to targeted medicines and hormonal therapy when compared to endometrioid EC. Furthermore, the increased susceptibility of nonendometrioid tumors to harbor mutations in the TP53 gene is noted, which, in turn, can contribute to a poorer prognosis [21,22].…”

“…Several studies have been conducted to evaluate the different histopathological, clinical status, and treatment outcomes of the EC population. Studies have also been conducted to study the EC population with distant metastasis in the bone and lungs; however, there is still a lack of studies on liver metastasis [7]. This study was performed using the Surveillance, Epidemiology, and End Results (SEER) database to evaluate and assess the clinical features and prognostic factors of EC patients with liver metastasis.…”

Clinicopathological Features, Prognostic Factors and Survival in Patients With Pancreatic Cancer Bone Metastasis

“…Patients over 60 years old are generally considered the elderly. Based on previous literature (27,28), we divided the patients' age into >60 years old and ≤60 years old for convenient analysis. Although some researchers reported tumor site was an independent survival predictor of PC (29)(30)(31), our multivariate Cox regression analysis showed that tumor site was not correlated with OS or CSS in patients with PCBM.…”

“…Although some researchers reported tumor site was an independent survival predictor of PC (29)(30)(31), our multivariate Cox regression analysis showed that tumor site was not correlated with OS or CSS in patients with PCBM. For convenient analysis, patients' tumor size were divided into<5 and ≥5 cm based on previous literature (21,28). However, univariate Cox regression analysis showed tumor size was not correlated with survival.…”

Characteristics and Predictors of Long-Time Survivors in Non-Metastatic Gastric Signet Ring Cell Carcinoma: A Large Population-Based Study

“…The SEER database includes population-based data from 18 registration centers, which covers approximately 30% of the US population. 12 The SEER database includes data on demographics, cancer incidence, tumor-related clinicopathological features, and cancer treatment, thereby providing accessible information for clinical studies of malignant tumors, especially for rare tumor entities. 13 Ethical approval was obtained from the Ethics Committee of the Affiliated Hospital of the Medical School of Ningbo University.…”