Clinicopathological Characteristics and Mutation Profiling in Primary Cutaneous Melanoma

Yaman, Banu; Akalın, Taner; Kandıloğlu, Gülşen

doi:10.1097/dad.0000000000000241

Cited by 32 publications

(32 citation statements)

References 55 publications

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“…However, the rate of BRAF V600K mutation found was higher than that in most of the previously-reported results (Table II) (1,6,10,17). It should be noted that data gathered from closer geographical regions to that of the present study showed similar results, including higher rates of V600K mutations (15,18,19). The difference in the rate of V600K mutations may be due to the sequencing method (sequencing the entire exon 15 genome) used in other studies.…”

Section: Discussionsupporting

confidence: 67%

“…Although it is said that the BRAF V600K mutation is rare, a few recent papers report higher rates of this mutation (20 to 44%) in some populations (6)(7)(8)15). In the present study, the BRAF V600E mutation was the most common subtype of the BRAF gene, followed by the BRAF V600K mutation.…”

Section: Discussionmentioning

confidence: 49%

“…Many studies have revealed that the BRAF mutation is associated with younger age, nodular or superficial spreading histological type, tumour location on the trunk and intermittent sun exposure (5,15,17,20). Also, a study by Hughahl et al (22) revealed the association between higher rates of BRAF V600 immunohistochemistry expression and increased tumour thickness, presence of ulceration and higher rates of mitosis.…”

Section: Discussionmentioning

confidence: 99%

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Braf v600 mutation profile of metastatic melanoma in the thrace region of turkey

Can¹,

Taştekin²,

Yalta³

et al. 2018

TJPATH

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Objective: BRAF is the most common mutation in melanoma. The most common subtype is BRAF V600E, followed by V600K. Initially, the authors aimed to investigate whether clinicopathological features of melanoma are associated with BRAF mutations. We then aimed to present the relationships between the clinicopathological features and the mutated subtype (V600E vs V600K). Material and Method:61 patients with metastatic malignant melanoma (affecting the lymph node or other distant sites) were selected. Patient data regarding age at the time of diagnosis, sex, metastatic site (lymph node, distant metastasis or both) and primary tumour site were obtained from the hospital's database. Tissue samples containing at least 30% tumour cells were isolated from the specimens of 61 patients (24 samples from primary tumours and 37 from metastatic foci) for BRAF analysis. Comparisons between the BRAF V600 mutation and clinicopathological and histopathological features were performed.Results: BRAF V600 mutation was detected in 34 (55.7%) patients. The subtype was BRAF V600E in 22 (64.7%) patients, BRAF V600K in 11(32.4%) patients and BRAF V600R in 1(2.9%) patient. The crucial results of the present study may be summarized as follows: i) BRAF V600 mutation was more common in older patients and tumors with BRAF V600 mutation revealed necrosis and LVI more commonly than wild-type tumors, ii) BRAF V600K mutation was more common in older patients and BRAF V600K mutated tumors exhibited ulceration more commonly than tumors with BRAF V600E mutation (close to significant). Conclusion:The BRAF V600 mutation may have interactions with prognostic clinicoptahological features of melanoma including necrosis and lymphovascular invasion. V600K mutation may be more common than expected and may have different associations with properties of the tumor such as tumor ulceration and patient age. Investigation of the mutated subtype of the BRAF gene may therefore reveal more detailed data about the management of melanoma and may also prevent missing of candidates for BRAF inhibitor therapies.

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Section: Discussionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Braf v600 mutation profile of metastatic melanoma in the thrace region of turkey

Can¹,

Taştekin²,

Yalta³

et al. 2018

TJPATH

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show abstract

“…It is associated with male gender, young age, trunk localization and intermittent sun exposure [9] . Although not conclusive, it was suggested to be linked with rapid progression, poor RFS and short disease-specific survival (DSS) in several independent post-resection stage III melanoma data sets [10][11][12] .…”

Section: Discussionmentioning

confidence: 99%

“…Notably, his tumour harbors BRAF mutation, which is the most common oncogenic mutation in melanoma and frequently seen in nodular and superficial spreading melanoma [9] .…”

Section: Discussionmentioning

confidence: 99%

Skeletal muscle metastasis from malignant melanoma: a case report and review of the literature

Zhu

Selvarajan

Sittampalam

et al. 2015

CRCP

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Malignant head and neck melanoma

Pföhler

Vogt

Müller

2015

HNO

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About 15% of all cutaneous melanomas develop in the head and neck region. Mucosal melanomas are rare and represent only 1% of all melanomas, however, most frequently, these are located in the nose, the paranasal sinuses and the oral cavity. Visual diagnosis and reflected-light microscopy are relevant for the evaluation of melanoma-suspect lesions. Histological investigation of resected tumors need special skills of the histopathologist and includes in case of high-risk tumors investigations of mutations in the tumor tissue concerning NRAS, BRAF and KIT. The risk of lymphatic or hematogeneous spread rises with increasing tumor thickness and the presence of further prognostic risk factors such as ulceration of the primary tumor or the presence of mitoses within the tumor.

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Clinicopathological Characteristics and Mutation Profiling in Primary Cutaneous Melanoma

Cited by 32 publications

References 55 publications

Braf v600 mutation profile of metastatic melanoma in the thrace region of turkey

Braf v600 mutation profile of metastatic melanoma in the thrace region of turkey

Skeletal muscle metastasis from malignant melanoma: a case report and review of the literature

Malignant head and neck melanoma

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