Clinicopathological and Prognostic Significance of Octamer-Binding Transcription Factor 4 in Patients with Gastric Cancer: A Systematic Review and Meta-Analysis

Wei, Yuanfeng; Han, Lei; Wang, Chengtan; Zhang, Weihui; Wen, Xiaoman; Long, Hui-Deng; Xu, Zhongqiu; Guo, Hao; Liu, Yuchao; Wei, Dongmei; Qiu, Chengyu; Li, Ganxiong; Sun, Zhihui

doi:10.2217/bmm-2018-0086

Cited by 3 publications

(1 citation statement)

References 40 publications

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“…As for cervical cancer, Liu et al [297] found that the aberrant activity of HDAC1 in C-33A cells significantly increases the expression of octamer-binding embryonic transcription factor 4 (Oct4), a prognostic biomarker of various types of malignancies that plays a critical role in maintaining the pluripotency and self-renewal of embryonic stem cells [308][309][310][311]. The contribution of histone deacetylase 1 to the maintenance of stem properties in transformed cells was also shown in a recent study by Yokoi et al [312], where an abnormal HDAC 1 expression profile in the ME180 and CaSki cell lines led to the activation of the Oct4, Nanog, and SOX2 genes that exhibit oncogenic function.…”

Section: Changes In the Intensity Of Histone Acetylation During Oncog...mentioning

confidence: 99%

Deciphering the Mysterious Relationship between the Cross-Pathogenetic Mechanisms of Neurodegenerative and Oncological Diseases

Aleksandrova,

Neganova

2023

IJMS

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The relationship between oncological pathologies and neurodegenerative disorders is extremely complex and is a topic of concern among a growing number of researchers around the world. In recent years, convincing scientific evidence has accumulated that indicates the contribution of a number of etiological factors and pathophysiological processes to the pathogenesis of these two fundamentally different diseases, thus demonstrating an intriguing relationship between oncology and neurodegeneration. In this review, we establish the general links between three intersecting aspects of oncological pathologies and neurodegenerative disorders, i.e., oxidative stress, epigenetic dysregulation, and metabolic dysfunction, examining each process in detail to establish an unusual epidemiological relationship. We also focus on reviewing the current trends in the research and the clinical application of the most promising chemical structures and therapeutic platforms that have a modulating effect on the above processes. Thus, our comprehensive analysis of the set of molecular determinants that have obvious cross-functional pathways in the pathogenesis of oncological and neurodegenerative diseases can help in the creation of advanced diagnostic tools and in the development of innovative pharmacological strategies.

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Section: Changes In the Intensity Of Histone Acetylation During Oncog...mentioning

confidence: 99%

Deciphering the Mysterious Relationship between the Cross-Pathogenetic Mechanisms of Neurodegenerative and Oncological Diseases

Aleksandrova,

Neganova

2023

IJMS

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Hsa-miR-3658 down-regulates OCT4 gene expression followed by suppressing SW480 cell proliferation and migration

Hosseini

Soltani

Baharvand

et al. 2020

Biochemical Journal

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The pluripotency factor, OCT4 gene is a stemness marker that is involved in the tumorigenicity of different cancer types and knowing about molecular mechanisms of its regulation is crucially important. To date, a few microRNAs (miRNAs) are known to be regulators of OCT4 gene expression. Looking for the novel miRNAs which are capable of regulating OCT4 gene expression, our bioinformatics analysis introduced hsa-miR-3658 (miR-3658) as a bona fide candidate. Then, RT-qPCR results indicated that miR-3658 expression is decreased in colorectal cancer (CRC) tumor tissues, compared with normal pairs. Furthermore, RT-qPCR and western blot analysis showed that the OCT4 gene has been down-regulated following the miR-3658 overexpression. Consistently, dual-luciferase assay supported the direct interaction of miR-3658 with the 3′-UTR sequence of OCT4 gene. Unlike in HCT116 cells, overexpression of miR-3658 in SW480 cells brought about growth inhibition, cell cycle arrest and reduced cell migration, detected by flow cytometry, and scratch test assay. Overall, these findings demonstrated that miR-3658 as a tumor suppressor miRNA exerts its effect against OCT4 gene expression, and it has the potential of being used as a prognostic marker and therapeutic target against colorectal cancer.

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Prognostic Value of Oct4 in Colorectal Cancer: Analysis Using Immunohistochemistry and Bioinformatics Validation

Fang

Ni²,

Zhang

et al. 2020

Biomark. Med.

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Aim: This study was first performed to investigate the role of octamer-binding transcription factor 4 (OCT4) in colorectal cancer (CRC). Methods: The electronic databases were searched for the eligible studies. Odds ratios and hazard ratios were calculated. Functional analysis of OCT4 was examined. Results: Eight studies with 1480 CRC cases were identified. OCT4 expression was correlated with advanced clinical stage, tumor grade, lymph node metastasis, lymphatic invasion, and distal metastasis. OCT4 was an independent prognostic biomarker for predicting worse disease-specific survival and overall survival in CRC. The functional analyses demonstrated that OCT4 was involved in multiple functions, such as cell adhesion, phosphoinositide 3-kinase/Akt signaling, and regulating pluripotency of stem cells. Conclusion: OCT4 may be correlated with disease progression and metastasis, and could predict prognosis in CRC.

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Clinicopathological and Prognostic Significance of Octamer-Binding Transcription Factor 4 in Patients with Gastric Cancer: A Systematic Review and Meta-Analysis

Cited by 3 publications

References 40 publications

Deciphering the Mysterious Relationship between the Cross-Pathogenetic Mechanisms of Neurodegenerative and Oncological Diseases

Deciphering the Mysterious Relationship between the Cross-Pathogenetic Mechanisms of Neurodegenerative and Oncological Diseases

Hsa-miR-3658 down-regulates OCT4 gene expression followed by suppressing SW480 cell proliferation and migration

Prognostic Value of Oct4 in Colorectal Cancer: Analysis Using Immunohistochemistry and Bioinformatics Validation

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