Clinicopathological and prognostic features of primary clear cell carcinoma of the liver

Liu, Zhisheng; Ma, Weidong; Li, Huikai; Li, Qiang

doi:10.1111/j.1872-034x.2007.00264.x

Cited by 59 publications

(74 citation statements)

References 39 publications

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“…The median age of diagnosis is 56 years [4] Majority of these tumours have serum alpha-fetoprotein (AFP) levels of ≤ 20 ng/ml [5]. Similar findings were noted in our patient who was 62-year-old male and whose AFP was 12 ng/ml.…”

Section: Discussionsupporting

confidence: 72%

“…These tumor have a strong association with cirrhosis [2] and are frequently seen with HCV related chronic liver disease [3] as compared to classical HCC as was also seen in our case.…”

Section: Discussionsupporting

confidence: 50%

“…Clear cell ratio, capsule formation, preoperative liver function, and vascular invasion were independent risk factors for prognosis [3,4,13].…”

Section: Discussionmentioning

confidence: 99%

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Clear Cell Hepatocellular Carcinoma with Associated Tuberculosis-A Case Report

Bansal¹,

Rastogi²

2017

J Hepatol Gastroint Dis

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Clear cell hepatocellular carcinoma (CCHCC) is a rare variant of classical hepatocellular carcinoma (CHCC). Most of these cases pose a histological diagnostic dilemma with broad range of differentials of tumor with clear cell morphology. Use of immunostains or presence of classical hepatocellular carcinoma morphology focally aids in accurate diagnosis of these lesions.We report a case of a 62-year-old male who presented with loss of appetite and altered bowel habits for last 3 months. On investigation he was found to be HCV positive with genotype 1a and viral load of 3853865 IU/ml. His CECT revealed a well-defined hyper dense lesion of size 38 x 34 mm in segment V with a thin hypo dense rim. Contrast studies were suggestive of hepatocellular carcinoma with chronic liver disease. His PET CT revealed an FDG avid lesion in lung, biopsy from which showed caseating epithelioid granulomas. He underwent living donor related liver transplant. Explant liver tissue examined showed CCHCC with cirrhosis and several epithelioid granulomas.Occurrence of CCHCC with tuberculosis is a rare with no similar case has been reported in indexed English literature till date. We herein report the first case of CCHCC with coincidental Tuberculosis in an elderly male.

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Section: Discussionsupporting

confidence: 72%

“…These tumor have a strong association with cirrhosis [2] and are frequently seen with HCV related chronic liver disease [3] as compared to classical HCC as was also seen in our case.…”

Section: Discussionsupporting

confidence: 50%

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Clear Cell Hepatocellular Carcinoma with Associated Tuberculosis-A Case Report

Bansal¹,

Rastogi²

2017

J Hepatol Gastroint Dis

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“…Primary clear cell carcinoma of the liver (PCCCL) is an uncommon variant of HCC, representing less than 10% of all HCC cases [4,5]. Most patients with PCCCL are cirrhotic and over the age of 50 years, although PCCCL does proportionately affect more women than common-type HCC (2.30:1 in PCCCL verses 4.38:1 for conventional HCC) [4].…”

Section: Introductionmentioning

confidence: 99%

“…Most patients with PCCCL are cirrhotic and over the age of 50 years, although PCCCL does proportionately affect more women than common-type HCC (2.30:1 in PCCCL verses 4.38:1 for conventional HCC) [4]. The strongest risk factor for PCCCL is HCV infection, with no significant associations with HBV, alcohol abuse, NASH, hemochromatosis, autoimmune hepatitis (AIH), or primary biliary cirrhosis (PBC) [4,5]. Establishing the diagnosis of PCCCL is important due to the overall better prognosis of this lesion versus common-type HCC [4,6].…”

Section: Introductionmentioning

confidence: 99%

A Giant Primary Clear Cell Hepatocellular Carcinoma in a Young Woman without Cirrhosis

Chen¹

2015

J Clin Exp Pathol

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Primary clear cell carcinoma of the liver (PCCCL) is an uncommon variant of hepatocellular carcinoma, usually occurring in older patients with longstanding cirrhosis. We report a case of a giant PCCCL rupturing in a young woman without cirrhosis.A 29 year-old female who presented with a three month history of abdominal pain, nausea, vomiting, food intolerance, and unintentional weight loss, was found to have gastric varices and a large liver mass measuring 22.8 cm × 17.8 cm × 13.8 cm. The tumor was comprised of sheets of clear cells with delicate vesicular architecture, and was positive for Hepar 1, Glypican 3, and CD34 in a diffuse staining pattern and CD10 in a canalicular staining pattern, establishing the diagnosis of PCCCL. The patient died of hemorrhagic shock secondary to tumor rupture within two weeks of diagnosis. Conclusion:Although PCCCL most often occurs in older patients with cirrhosis, this uncommon variant of HCC can arise in younger patients without a history of liver disease. It is important to diagnose PCCCL early due to the potentially favorable prognosis of this specific cancer and in order to prevent catastrophic complications.

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Competing risk model for prognostic comparison between clear cell type and common type hepatocellular carcinoma: A population‐based propensity score matching study

Zhong

Fan

2023

Cancer Medicine

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Background Clear cell type hepatocellular carcinoma (HCC) is an uncommon neoplasm with an ambivalent prognosis compared to common type HCC. Methods First, patients with clear cell or common type HCC were enrolled from the Surveillance, Epidemiology, and End Results (SEER) database, and their demographic and clinical characteristics were identified. Next, overall survival (OS), disease‐specific survival (DSS), and subgroup analysis of the two types of HCC were performed. Next, we utilized a competing risk model to focus on cancer‐caused death. Finally, propensity score matching (PSM) was employed to reduce the confounding factors based on the histopathological type, and sensitivity analysis was conducted. Results A total of 205 cases of clear cell type HCC and 29,954 cases of common type HCC were enrolled in our study. Patients with clear cell type HCC were older and predominantly female than those with common type HCC. OS and DSS were not significantly different between the two groups, and histopathological type was not a prognostic factor of HCC, as verified by the competing risk model. Patient characteristics adjusted by PSM and sensitivity analysis confirmed this conclusion. In subgroup analysis, patients with clear cell type HCC at grade III ~ IV and with lymph nodes metastasis had a better prognosis compared to common type HCC. Conclusions This study revealed that the prognosis of clear cell type HCC is similar to common type HCC. Tumor differentiation grade and status of lymph node metastasis affect the prognosis of HCC.

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Clinicopathological and prognostic features of primary clear cell carcinoma of the liver

Abstract: The notable clinicopathological features of the patients in the PCCCL group included a higher rate of HCV infection, capsule formation, and a lower rate of vascular invasion. The prognosis was better than that of the patients in the CHCC group and related to the ratio of clear cells.

Cited by 59 publications

References 39 publications

Clear Cell Hepatocellular Carcinoma with Associated Tuberculosis-A Case Report

Clear Cell Hepatocellular Carcinoma with Associated Tuberculosis-A Case Report

A Giant Primary Clear Cell Hepatocellular Carcinoma in a Young Woman without Cirrhosis

Competing risk model for prognostic comparison between clear cell type and common type hepatocellular carcinoma: A population‐based propensity score matching study

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