Clinicopathological and immunohistochemical analysis of 19 cases of oral eosinophilic ulcers

Fonseca, Felipe Paiva; Andrade, Bruno Augusto Benevenuto de; Coletta, Ricardo D.; Vargas, Pablo Agustı́n; Lopes, Márcio Ajudarte; Almeida, Oslei Paes de; Santos‐Silva, Alan Roger

doi:10.1016/j.oooo.2012.11.007

Cited by 21 publications

(44 citation statements)

References 18 publications

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“…Eosinophilic ulcers usually occur in the fifth and seventh decades of life with equal distribution between males and females; however, a slight male predilection was noted by Fonseca et al 7. The tongue is the most commonly involved site in about 60% of the cases.…”

Section: Discussionmentioning

confidence: 97%

“…Eosinophilic ulcer of the oral mucosa was first described in adults by Popoff in 1956 and, in 1970, it was identified as a distinct entity by Shapiro and Juhlin 6 7. Since then, names such as eosinophilic ulcer, traumatic eosinophilic granuloma of the tongue, traumatic granuloma, atypical histiocytic granuloma and TUGSE have been used to describe the lesion.…”

Section: Discussionmentioning

confidence: 99%

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Eosinophilic ulcer of the tongue: a rare and confusing clinical entity

Lingaraju¹,

Gaddelingiah

Shivalingu³

et al. 2015

BMJ Case Reports

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Eosinophilic ulcers are rare, benign, reactive and often self-limiting lesions of the oral cavity. Although the aetiology is not clear, trauma is believed to play a role in their development. Clinically, the lesion manifests as an isolated ulcer, with raised, indurated borders and a yellow fibrinous floor; because of its long duration it often leads to the suspicion of squamous cell carcinoma. Although the ulcer is benign in nature, a biopsy is necessary to rule out malignancy. Histopathologically, the ulcer is characterised by the presence of dense inflammatory infiltrate extending into the deeper muscle layers with sheets of lymphocytes intermixed with eosinophils. This is a case report of a 65-year-old woman with an eosinophilic ulcer on the lateral border of the tongue. The ulcer healed rapidly after an incisional biopsy and topical steroid application. The final diagnosis was achieved following clinical and histopathological examination.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Eosinophilic ulcer of the tongue: a rare and confusing clinical entity

Lingaraju¹,

Gaddelingiah

Shivalingu³

et al. 2015

BMJ Case Reports

View full text Add to dashboard Cite

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“…Smaller ulcers may be seen in autoimmune disease (e.g., Sjogren's syndrome), granulomatous cheilitis, and Crohn's disease. [ 3 13 14 15 16 ] The clinical and microscopic features together with special stains for micro-organisms and immunohistochemical markers should assist in distinguishing these conditions.…”

Section: Discussionmentioning

confidence: 99%

“…They may be due to released tissue toxins or other reactants. [ 14 15 16 17 ] Eosinophils may be present in a variety of cutaneous and gastrointestinal conditions, often related to allergic, parasitic or drug-related causes, or as part of a systemic eosinophilia. However, in the most cases of oral eosinophilic ulceration these conditions are not evident.…”

Section: Discussionmentioning

confidence: 99%

Oral eosinophilic or traumatic ulcer: A case report and brief review

Dhanrajani

Cropley²

2015

Natl J Maxillofac Surg

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Eosinophilic ulcer of the oral mucosa is considered to be a benign, reactive, and self-limiting lesion, with unclear pathogenesis, manifesting as a rapidly developing solitary ulcer. We report a case of a 42-year-old man who presented with a chronic indurated ulcer of buccal mucosa adjacent to the right upper wisdom tooth. Histopathological examination showed polymorphic inflammatory infiltrate, rich in eosinophilis, involving the superficial mucosa, and the deeper muscle layer. Immunohistochemical analysis revealed single CD30+ cells scattered within an inflammatory infiltrate. The lesion was excised, and healing was uneventful with no recurrence in more than a year.

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“…The injury is identified, however, in less than 50% of cases. 2,4,[6][7][8][9][10][11] Simultaneous lesions are extremely rare. Elzay 3 argues that the presence of multiple ulcers excludes trauma as the only predisposing factor.…”

Section: Discussionmentioning

confidence: 99%

Eosinophilic Ulcer of the Oral Mucosa

Damevska

Gocev²,

Nikolovska³

2014

The American Journal of Dermatopathology

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Eosinophilic ulcer of the oral mucosa is considered to be a benign, reactive, and self-limiting lesion, with unclear pathogenesis, manifesting as a rapidly developing solitary ulcer. We report the case of a 52-year-old man who presented with 4 synchronous ulcerations of the tongue. Histopathological examination showed polymorphic inflammatory infiltrate, rich in eosinophils, involving the superficial mucosa and the deeper muscle layer. Immunohistochemical analysis revealed single CD30 cells scattered within an inflammatory infiltrate. All the lesions began to regress spontaneously within 1 week after biopsy. A 4-year follow-up showed no recurrence.

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Clinicopathological and immunohistochemical analysis of 19 cases of oral eosinophilic ulcers

Abstract: Considering the clinical, histopathological, and immunohistochemical characteristics, oral eosinophilic ulcers must be considered a self-limiting reactive condition.

Cited by 21 publications

References 18 publications

Eosinophilic ulcer of the tongue: a rare and confusing clinical entity

Eosinophilic ulcer of the tongue: a rare and confusing clinical entity

Oral eosinophilic or traumatic ulcer: A case report and brief review

Eosinophilic Ulcer of the Oral Mucosa

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