Clinicopathological analysis of thyroid carcinomas with the RET and NTRK fusion genes: characterization for genetic analysis

Okubo, Yoichiro; Toda, Soji; Kadoya, Mei; Sato, Shinya; Yoshioka, Emi; Hasegawa, Chie; Ono, Kyoko; Washimi, Kota; Yokose, Tomoyuki; Miyagi, Yohei; Masudo, Katsuhiko; Iwasaki, Hiroyuki; Hayashi, Hiroyuki

doi:10.1007/s00428-024-03777-w

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“…Tumors arising from the deep soft tissue mainly occur in middle-aged adults with no sex predilection [ 15 ]. Histological assessment using imaging is typically difficult, and detailed histological analysis is important for diagnosis [ 15 , 17 , 18 ]. The diagnostic criteria for primary leiomyomas from deep soft tissues are stringent [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Primary omental smooth muscle tumor in an adult male: a diagnostic dilemma for leiomyoma: a case report

Ono,

Okubo,

Washimi

et al. 2024

J Med Case Reports

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Background The greater omentum comprises peritoneal, adipose, vascular, and lymphoid tissues. Most omental malignancies are metastatic tumors, and the incidence of primary tumors is rare. We report on a prior omental smooth muscle tumor case in an adult male patient. Case presentation A 54-year-old Japanese male patient with no relevant medical history was diagnosed with an abdominal mass during a routine medical checkup. Subsequent contrast-enhanced computed tomography revealed a mass of approximately 3 cm in size in the greater omentum, and a laparotomy was performed. A 27 × 25 × 20 mm raised lesion was found in the omentum. Microscopically, spindle cells were observed and arranged in whorls and fascicles. Individual tumor cells had short spindle-shaped nuclei with slightly increased chromatin and were characterized by a slightly eosinophilic, spindle-shaped cytoplasm. The mitotic count was less than 1 per 50 high-power fields. The tumor cells showed positive immunoreactivity for α smooth muscle actin, HHF35, and desmin on immunohistochemical examination. The Ki-67 labeling index using the average method was 1.76% (261/14806). No immunoreactivity was observed for any of the other tested markers. We considered leiomyoma owing to a lack of malignant findings. However, primary omental leiomyoma has rarely been reported, and it can be difficult to completely rule out the malignant potential of smooth muscle tumors in soft tissues. Our patient was decisively diagnosed with a primary omental smooth muscle tumor considering leiomyoma. Consequently, the patient did not undergo additional adjuvant therapy and was followed up. The patient was satisfied with treatment and showed neither recurrence nor metastasis at the 13-month postoperative follow-up. Discussion and conclusion We encountered a primary smooth muscle tumor of the greater omentum with no histological findings suggestive of malignancy in an adult male patient. However, omental smooth muscle tumors are extremely difficult to define as benign, requiring careful diagnosis. Further case reports with long-term follow-up and case series are required to determine whether a true omental benign smooth muscle tumor (leiomyoma) exists. In addition, proper interpretation of the Ki-67 labeling index should be established. This case study is a foundation for future research.

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