Clinicopathological analysis of oral Burkitt's lymphoma in pediatric patients: A systematic review

Rodrigues-Fernandes, Carla Isabelly; Pérez‐de‐Oliveira, Maria Eduarda; Arboleda, Lady Paola Aristizábal; Fonseca, Felipe Paiva; Lopes, Márcio Ajudarte; Vargas, Pablo Agustı́n; Santos‐Silva, Alan Roger

doi:10.1016/j.ijporl.2020.110033

Cited by 12 publications

(16 citation statements)

References 36 publications

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“…HIV is associated with BL in approximately 30% of cases. 7 However, in the present study, an HIV-positive status was only recorded in 3 patients (5.77%), including two Brazilian patients aged 19 and 24 years, and one 28-year-old Guatemalan patient. As in…”

Section: Historically It Is Known That Ebl Is Typically Found In Equatorialcontrasting

confidence: 67%

“…Clinically, features such as swelling, pain/odontalgia, tooth mobility/loosening, chin numbness, and systemic symptoms (fever, weight loss, and headache) are common in BLHN. [5][6][7] Three main clinical variants of BL have been described: endemic, sporadic, and immunodeficiency-associated, each of them presenting specific epidemiological and clinical features. Endemic BL (eBL) commonly affects facial bones and adjacent soft tissues of Equatorial African pediatric patients, and has a strong association with Epstein-Barr virus (EBV) infection (>90%).…”

Section: Introductionmentioning

confidence: 99%

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Burkitt lymphoma of the head and neck: An international collaborative study

Arboleda

Rodrigues-Fernandes

Mariz

et al. 2021

J Oral Pathology Medicine

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Background: Burkitt lymphoma (BL) is an aggressive B-cell lymphoma with three variants (endemic, sporadic, and immunodeficiency-associated), presenting with specific epidemiological and clinical features. Burkitt lymphoma affects the head and neck region (BLHN) in approximately 10% of cases. The aim of this study was to undertake a comparative analysis of the clinicopathologic and immunohistochemical (IHC) features of BLHN diagnosed in patients from Africa, Guatemala, and Brazil. Methods: Cases diagnosed as BLHN were collected from the files of six oral pathology laboratory services (Brazil, South Africa, and Guatemala) and one Brazilian pediatric oncology hospital from 1986 to 2020. Clinicopathological and IHC data, and Epstein-Barr virus (EBV) status by in situ hybridization data for each case were reviewed and described. Results: Of the 52 cases, BLHN was predominant in pediatric patients [43 (82.69%)] and males [43 (82.69%)], with a mean age of 11.26 ± 9.68 years (range, 1-39 years). Neck and cervical lymph nodes [14 (26.92%)], and involvement of both maxilla and mandible [8 (15.38%)], were the most common anatomical sites. Clinically, tumor/ swelling [40 (31.25%)], cervical lymphadenopathy [14 (10.94%)], pain [12 (9.38%)], and bone destruction [12 (9.38%)] were frequent findings. All cases showed typical morphological characteristics of BL. IHC profiles included positivity for CD20 [52 (100%)], CD10 [38 (79.17%)], Bcl6 [29 (87.88%)], and c-Myc protein [18 (81.82%)]. EBV was positive in 18 cases (62.07%). The Ki-67 index ranged from 90 to 100%. Special issue "Lymphomas and lymphoid lesions of the oral cavity".| 573 ARBOLEDA Et AL.

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Section: Historically It Is Known That Ebl Is Typically Found In Equatorialcontrasting

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Burkitt lymphoma of the head and neck: An international collaborative study

Arboleda

Rodrigues-Fernandes

Mariz

et al. 2021

J Oral Pathology Medicine

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“…One must be aware of pathology other than dental infection when cortical bone is absent. BL has a predominance in males, mostly in young patients 6,7,10,17 …”

Section: Discussionmentioning

confidence: 99%

Burkitt lymphoma in children causing an osteolytic lesion in the mandible: A case report

Coninck

Govaerts

Bila

et al. 2020

Clinical Case Reports

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“…BL has a predominance in males, mostly in young patients. 6,7,10,17 The panoramic radiograph (Figure 2) shows the dentition in transition from deciduous to permanent. The second molar of each quadrant is in development given the incomplete root formation.…”

Section: Discussionmentioning

confidence: 99%

“…BL is considered to have an aggressive behavior and moderate overall survival rate. 17 Imaging is the first step in diagnosing a persistent swelling of the jaw. A lymphoma in the jaw typically manifests as a poor defined osteolytic lesion.…”

Section: Discussionmentioning

confidence: 99%