Clinicopathological Analysis of Early-Stage Gastric Cancers Detected After Successful Eradication of Helicobacter pylori

Abstract

Our findings indicate that the clinicopathological characteristics of gastric cancers detected after H. pylori eradication are different from those of gastric cancers in patients with persistent H. pylori infection. H. pylori eradication may suppress intestinalization during the development of gastric cancer.

A Comparative Study of White Light Endoscopy, Chromoendoscopy and Magnifying Endoscopy with Narrow Band Imaging in the Diagnosis of Early Gastric Cancer after Helicobacter pylori Eradication

“…However, gastric cancer is discovered in patients even after successful H. pylori eradication [5]. Moreover, H. pylori eradication influences the clinicopathological features of gastric tumors, including macro-and microscopic appearances [6][7][8][9][10]. Gastric cancer found after H. pylori eradication appears with indistinct forms, such as tiny and flattened lesions [6][7][8].…”

Morphologic Characterization of Residual DNA Methylation in the Gastric Mucosa after Helicobacter Pylori Eradication

“…Gastric cancer incidence after H. pylori eradication is increasing recently, but it is difficult to find it because of its ambiguity. [14]. Our result might provide more appropriate clinical implementation for gastric cancer surveillance after eradication, reflecting individual cancer risk.…”

“…The data also demonstrated that the therapy could reverse the hypermethylation in certain genes [11,12]. Even after successful H. pylori eradication, on the other hand, gastric cancers are sometimes identified [13,14]. The residual methylation in gastric mucosa after eradication might be relevant to this process [12,15].…”

Endoscopic Detection of Gastric Carcinoma After Helicobacter pylori Eradication: More Difficult or Just Hype?

“…Including the reports by Yamamoto et al [1] and Matsuo et al [2], [10 studies of GC detected after Hp eradication have been published to date [3][4][5][6][7][8][9][10]. The characteristics of post-eradication GC include: (a) detection *40 months after eradication; (b) lesions are histologically well differentiated; (c) gross lesion morphology is depressed; and (d) the lesions are small (10-20 mm diameter).…”

“…The characteristics of post-eradication GC include: (a) detection *40 months after eradication; (b) lesions are histologically well differentiated; (c) gross lesion morphology is depressed; and (d) the lesions are small (10-20 mm diameter). Pathologically, the Ki-67 index and Wnt5a expression are significantly reduced [1,11]. In some patients, the mucosa surrounding the lesion is obscured [11], possibly due to the flattening of the tumor tissue, with formation of non-neoplastic foveolar epithelium as the outermost layer.…”