Clinicopathologic study on cholangiolocellular carcinoma

Shiota, Koji; Taguchi, Jun; Nakashima, Osamu; Nakashima, Miwako; Kojiro, Masamichi

doi:10.3892/or.8.2.263

Cited by 69 publications

(78 citation statements)

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“…It can therefore be concluded that primary intermediate carcinoma of the liver may be a distinct type of liver carcinoma, which arises from hepatic progenitor cells with the potential of differentiation into both hepatocytic and cholangiocytic lineage. Another tumor that might be derived from hepatic progenitor cell is cholangiolocellular carcinomas [29]. Although there is as yet no consensus on the criteria for cholangiolocellular carcinoma, some have described the histological features as cells no larger than the usual CC arranged in small, regular narrow tubular structures resembling the canals of Hering with frequent anastomoses, which differed from the histology of our intermediate carcinoma.…”

Section: Discussionmentioning

confidence: 56%

Primary liver carcinoma of intermediate (hepatocyte–cholangiocyte) phenotype

Kim

Park

Han

et al. 2004

Journal of Hepatology

193

151

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Section: Discussionmentioning

confidence: 56%

Primary liver carcinoma of intermediate (hepatocyte–cholangiocyte) phenotype

Kim

Park

Han

et al. 2004

Journal of Hepatology

193

151

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“…infections, alcoholism, or hemochromatosis, with higher frequency than patients with CCC. 1,3,7,8 This is thought to result from the observation that hepatic stem cells are activated during chronic liver injury. Our patient was negative for HBs-Ag and HCV-Ab, but HBs-Ab and HBc-Ab were positive.…”

Section: Discussionmentioning

confidence: 99%

“…The incidence of CoCC was reported to be 0.56% in patients with resected primary liver cancer. 1 Although CoCC was first described by Steiner and Higginson in 1959, 2 the histogenesis of CoCC was unclear for many years; however, recent studies have shown that CoCC originates from hepatic stem cells, which exist in the canals of Hering. [3][4][5] Hepatic stem cells have the potential to differentiate into both hepatocytes and cholangiocytes.…”

mentioning

confidence: 99%

Giant Cholangiolocellular Carcinoma With Early Recurrence That Was Difficult to Distinguish From Cholangiocellular Carcinoma: Report of a Case

Ishii

Suzuki

Tsukagoshi

et al. 2015

International Surgery

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Cholangiolocellular carcinoma (CoCC) is a rare type of malignant liver tumor derived from hepatic stem cells, which exist in the canals of Hering. However, the characteristics of CoCC have not been clarified. In general, CoCC is associated with a better prognosis than cholangiocellular carcinoma (CCC). Here, we report a case of giant CoCC, which was difficult to distinguish from CCC and showed early recurrence and necrosis inside the tumor. A 59-year-old man was diagnosed with CCC based on preoperative imaging. The diameter of the tumor was approximately 14 cm, and he subsequently underwent extended right lobectomy of the liver. Histopathologic analysis revealed that tumor cells proliferated and replaced the surrounding normal liver cell cords in front of the tumor. Furthermore, the tumor cells were positive for cytokeratin 19 and epithelial membrane antigen. Epithelial membrane antigen staining pattern was positive on the membranous area of the lumen. Therefore, the tumor was diagnosed as CoCC. Although adjuvant chemotherapy was performed, intrahepatic recurrence occurred at 4 months after surgery. We present here the novel characteristics of CoCC that show early recurrence and necrosis within the tumor. These characteristics have not previously been reported in patients with CoCC.

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“…Because of its low frequency, clinicopatholigical features of CLC have not been clarified. The clinicopatholigical characteristics and findings of images were studied on 9 cases of CLC whose clinical courses were reported in Japan (3,4). Five of these 9 patients (56%) were infected with HCV, one (11%) was infected with HBV, and 3 (33%) were negative for both HCV antibody and HBs antigen ( Table 2).…”

Section: Discussionmentioning

confidence: 99%