Clinicopathologic study of mixed adenoneuroendocrine carcinomas of hepatobiliary organs

Harada, Kenichi; Sato, Yasunori; Ikeda, Hiroko; Hsu, Maylee; Igarashi, Satoru; Okamura, Atsushi; Masuda, Shinji; Nakanuma, Yasuni

doi:10.1007/s00428-012-1212-4

Cited by 93 publications

(130 citation statements)

References 11 publications

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“…MANEC histogenetic definition represents a current controversial issue among pathologists [1,2,4,5,6,7,8]. Two main theories have been formulated: (a) these tumors might arise independently in a synchronous or metachronous fashion, or (b) they might derive from a common, multipotent stem/progenitor cell.…”

Section: Introductionmentioning

confidence: 99%

Mixed Adenoneuroendocrine Carcinomas of the Gastrointestinal Tract: Targeted Next-Generation Sequencing Suggests a Monoclonal Origin of the Two Components

Vittoria²,

et al. 2014

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Background: Mixed adenoneuroendocrine carcinomas (MANECs) of the gastrointestinal tract are rare neoplasms characterized by coexisting exocrine and neuroendocrine neoplastic components. MANECs' histogenetic classification and molecular characterization remain unclear, significantly affecting the identification of innovative therapeutic options for these tumors. Methods: The exocrine and neuroendocrine components of 6 gastrointestinal MANECs were microdissected and subjected to the simultaneous mutation assessment in selected regions of 54 cancer-associated genes using Ion Torrent semiconductor-based next-generation sequencing. Sanger sequencing and immunohistochemistry were used as validation of the mutational status. Results: A total of 20 driver gene somatic mutations were observed among the 12 neoplastic components investigated. In 11 of 12 (91.7%) samples, at least one mutation was detected; 7 samples (58.3%) were found to have multiple mutations. TP53 gene mutations were the most frequent genetic alterations observed in the series, occurring in 11/12 samples (91.7%). Somatic mutations in other genes were detected at lower frequencies: ATM, CTNNB1, ERBB4, JAK3, KDR, KRAS, RB1. Conclusions: Five of the 6 MANECs presented an overlapping mutational profile in both components, suggesting a monoclonal origin of the two MANEC components.

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Section: Introductionmentioning

confidence: 99%

Mixed Adenoneuroendocrine Carcinomas of the Gastrointestinal Tract: Targeted Next-Generation Sequencing Suggests a Monoclonal Origin of the Two Components

Vittoria²,

et al. 2014

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“…In general, MANECs are highly aggressive tumour types with a high risk for distant metastasis, and prognosis is often dismal. It is largely unclear whether the glandular or the neuroendocrine component is the major driving force of disease progression and thus crucial for metastatic cancer spread (11,20,21).…”

Section: Discussionmentioning

confidence: 99%

Mixed adenoneuroendocrine carcinoma of the ampulla of Vater: A case report

Max

Rothe

Langner

2016

Molecular and Clinical Oncology

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Abstract. Mixed adenoneuroendocrine carcinomas (MANECs) are rare biphasic tumour types, which are morphologically recognisable as both gland-forming and neuroendocrine neoplasms. Within the gastrointestinal tract, MANECs occur predominantly in the stomach or colorectum. The present study described a case of a MANEC originating from the ampullary region. The patient presented with widespread metastatic disease. Biopsy samples obtained from the ampullary primary tumour disclosed a complex lesion with adenocarcinoma and neuroendocrine small cell carcinoma components, positive for the intestinal transcription factor caudal type homeobox-2 and for neuroendocrine markers, including chromogranin A, synaptophysin, cluster of differentiation 56/neural cell adhesion molecule. By contrast, biopsy samples obtained from metastatic tissue revealed pure neuroendocrine carcinoma. As exemplified by this true mixed tumour, tumour heterogeneity evolves as the major challenge in oncology today, with potentially severe implications for the choice of chemotherapy. The assessment of metastatic sites may render valuable diagnostic information that is crucial for clinical decision-making and patient management.

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“…Agonists with high selectivity for SSTR2 or SSTR5 could suppress gallbladder emptying, whereas SSTR1-, SSTR3-and SSTR4-selective agonists failed to cause gallbladder contraction (Kaczmarek et al, 2010) and SST induced apoptosis concerning the expression of p53 and Bax protein (Songgang et al, 2009). Consider of less clinical cases in our research, further study on more cases of gallbladder cancer patients need to be carried on the mechanism of SSTR mediated gallbladder cancer and the mechanism of SSTR participates gallbladder cancer formation needs to carry out (Behr et al, 2002;Fiebiger et al, 2002;Chopra, 2004;Harada et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Somatostatin Receptors 3, 4 and 5 Play Important Roles in Gallbladder Cancer

Guo

Shi²,

Zhou³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Clinicopathologic study of mixed adenoneuroendocrine carcinomas of hepatobiliary organs

Abstract: SUMMARYBackgrounds: Neuroendocrine neoplasms in hepatobiliary organs are very rare, but several cases of

Cited by 93 publications

References 11 publications

Mixed Adenoneuroendocrine Carcinomas of the Gastrointestinal Tract: Targeted Next-Generation Sequencing Suggests a Monoclonal Origin of the Two Components

Mixed Adenoneuroendocrine Carcinomas of the Gastrointestinal Tract: Targeted Next-Generation Sequencing Suggests a Monoclonal Origin of the Two Components

Mixed adenoneuroendocrine carcinoma of the ampulla of Vater: A case report

Somatostatin Receptors 3, 4 and 5 Play Important Roles in Gallbladder Cancer

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