Clinicopathologic Spectrum of Cutaneous Tuberculosis

Sharma, Sonal; Sehgal, Virendra; Bhattacharya, Sambit; Mahajan, Garima; Gupta, Richa

doi:10.1097/dad.0000000000000297

Cited by 32 publications

(34 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Lupus vulgaris, the commonest form of cutaneous tuberculosis, is acquired via hematogenous, lymphatic or contiguous spread from an internal focus or via exogenous inoculation in pre‐sensitized individuals . Lupus vulgaris occurring at atypical sites often leads to delayed diagnosis, inappropriate treatment, and significant long‐term sequelae such as scarring and mutilation.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Bilateral ear lobe infiltration: an unusual presentation of lupus vulgaris

Khullar

Saxena

2019

Int J Dermatology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

“…Lupus vulgaris is the most common variant of cutaneous tuberculosis in India . The typical sites of involvement include the trunk, buttocks, and lower extremities.…”

Section: Introductionmentioning

confidence: 99%

Bilateral ear lobe infiltration: an unusual presentation of lupus vulgaris

Khullar

Saxena

2019

Int J Dermatology

View full text Add to dashboard Cite

“…Differential diagnosis includes erythema nodosum and nodular vasculitis . In contrast to EIB, erythema nodosum is considered a septal panniculitis of the subcutis, caused by an inflammatory reaction, and triggered by a multitude of antigenic stimuli including viral, bacterial and mycobacterial antigens …”

Section: Discussionmentioning

confidence: 99%

Tuberculids: cutaneous indicator diseases of Mycobacterium tuberculosis infection in young patients

Hallensleben

Vries

Lettinga

et al. 2016

Acad Dermatol Venereol

View full text Add to dashboard Cite

show abstract

“…The primary site of infection is usually the lung causing pulmonary tuberculosis. Cutaneous tuberculosis constitutes 1.5% of tuberculosis patients and is about 0.09‐0.9% of total dermatology out patients . The diagnosis of cutaneous tuberculosis is challenging due to its diverse clinical manifestations, paucibacillary state and lack of proper diagnostic tests.…”

Section: Introductionmentioning

confidence: 99%

Cytomorphological spectrum and immunochemistry of cutaneous tuberculosis

Murry

Sharma

Arora

et al. 2018

Diagnostic Cytopathology

Self Cite

View full text Add to dashboard Cite

Objectives The diagnosis of cutaneous tuberculosis is challenging due to its diverse clinical manifestations, paucibacillary state and lack of proper diagnostic tests. Clinico‐pathological correlation is still frequently used for diagnosis. There is paucity of literature on cytomorphological features. Immunochemistry can help as an ancillary test. Methods Clinical diagnosis was made after thorough history and physical examination. Modified Fine Needle Aspiration technique was used to collect cytology samples and 3 mm punch biopsy for histological examination. Findings on histopathology were compared with cytomorphology. Immunochemical staining with anti‐TB polyclonal antibody using standard Polymer‐based‐HRP immunochemistry technique and comparison of cytology and histology findings. Results The morphological spectrum of biopsy and cytology showed high correlation using nine parameters: necrosis, granulomas, giant cells, AFB, neutrophilic infiltrate, presence of lymphocytes, histiocytes, collagen bundles, and immunochemistry. Diagnostic correlation of FNA compared to biopsy was found to be 90.3%. On comparing cytomorphology of scrofuloderma and lupus vulgaris, all the parameters were found more frequently in scrofuloderma except for granulomas, giant cells and immunochemistry. Immunochemistry showed sensitivity and specificity of 90.3% and 70% on biopsy, respectively, compared to 67.7% and 60% on FNA, respectively. Combined sensitivity of IHC and ICC was 96.8%. Conclusions The cytomorphological spectrum of cutaneous tuberculosis is comparable to clinicohistopathology with a high correlation of 90.3%. However, sub classification on FNA is difficult on cytology alone. While FNAC is a better diagnostic tool for finding AFBs hence confirming the diagnosis, biopsy is better for immunochemistry. Thus, biopsy and FNA complement each other.

show abstract

Clinicopathologic Spectrum of Cutaneous Tuberculosis

Abstract: CTB has a varied clinical and morphological spectrum. Cytology and histopathology play a key role in its diagnosis. An additional adjunct is the clinical response to antituberculosis treatment.

Cited by 32 publications

References 25 publications

Bilateral ear lobe infiltration: an unusual presentation of lupus vulgaris

Bilateral ear lobe infiltration: an unusual presentation of lupus vulgaris

Tuberculids: cutaneous indicator diseases of Mycobacterium tuberculosis infection in young patients

Cytomorphological spectrum and immunochemistry of cutaneous tuberculosis

Contact Info

Product

Resources

About