Clinicopathologic Significance of Eosinophilic Pleural Effusions in a Population with a High Prevalence of Tuberculosis and Cancer

Özkara, Sevgiye Kaçar; Turan, Gupse; Başyiğit, İlknur

doi:10.1159/000325841

Cited by 18 publications

(26 citation statements)

References 15 publications

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“…After a more detailed review, an additional 15 papers did not meet the inclusion criteria and were excluded. The remaining 15 studies were reviewed [1,5,6,[12][13][14][15][16][17][18][19][20][21][22][23] for duplicate publications. We did not find any duplicate publications.…”

Section: Studies and Cases Identifiedmentioning

confidence: 99%

“…Cases of EPE on repeated thoracentesis were reclassified as pleural air/ blood whenever possible. However, this reclassification was not possible in 4 studies because of lack of information [1,13,15,22] .…”

Section: Studies and Cases Identifiedmentioning

confidence: 99%

“…The prevalence of EPEs in all pleural effusions was reported in 12 studies [5,[13][14][15][16][17][18][19][20][22][23][24] . The pooled prevalence of EPEs was 9% (random-effects model, 95% CI 7-10).…”

Section: Studies and Cases Identifiedmentioning

confidence: 99%

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The Prevalence and Diagnostic Significance of Eosinophilic Pleural Effusions: A Meta-Analysis and Systematic Review

Oba

Abu-Salah²

2011

Respiration

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(21 vs. 30%; p = 0.01). The likelihood of malignancy was inversely correlated with the pleural fluid eosinophil counts. The likelihood of idiopathic effusion was significantly higher in EPEs than in non-EPEs. Conclusions: Malignancy was the most common cause of EPEs. EPEs appeared to be a negative predictor of malignancy when a pleural fluid eosinophil count was extremely high. EPEs were more likely to be idiopathic as compared with non-EPEs.

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Section: Studies and Cases Identifiedmentioning

confidence: 99%

Section: Studies and Cases Identifiedmentioning

confidence: 99%

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The Prevalence and Diagnostic Significance of Eosinophilic Pleural Effusions: A Meta-Analysis and Systematic Review

Oba

Abu-Salah²

2011

Respiration

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“…It should also be noted that other authors reported a higher percentage of patients with EPE of unknown origin. This percentage, however, did not exceed 30-32% [2,20]. A lower number of patients with unknown cause of EPE in the recent studies might be related to the advances in the diagnosis of pleural effusion, but also to changing aetiology of EPE.…”

Section: Drug-induced Eosinophilic Pleural Effusionmentioning

confidence: 79%

“…Analysis of different studies shows that the epidemiology of EPE might be closely related to the local epidemiological setting. The percentage of tuberculous effusion in EPEs developing in populations with a high prevalence of tuberculosis was as high as 10-39.6% [20,22], while it was only 0-2% in the setting of low or intermediate tuberculosis prevalence [2,18,23]. In our previous study, an interesting relationship was found between the percentage of eosinophils and EPE aetiology.…”

Section: Drug-induced Eosinophilic Pleural Effusionmentioning

confidence: 89%

Drug-induced eosinophilic pleural effusion

Krenke¹,

Light²

2011

European Respiratory Review

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Eosinophilic effusions: A clinicocytologic study of 12 cases

AbdullGaffar

2018

Diagnostic Cytopathology

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Objectives Our aim is to study the prevalence of eosinophilic effusions (EEs) in our institution, to highlight their cytologic patterns, potential interpretation pitfalls, diagnostic importance, and to investigate their possible causes and clinical associations. Materials and Methods We conducted a retrospective review study for over 13 years. We retrieved all of the cytology reports of pleural, pericardial, and peritoneal effusions with eosinophils. We reviewed and screened the cytology slides looking for eosinophils that constitute >10% of the cells. We extracted the clinical, radiologic, and laboratory findings and follow‐up data for each patient. Results We found 12 patients (0.7%) with EEs. They included five pleural, five peritoneal, and two pericardial fluids. The age range was between 16 and 75 with a mean age of 36.5 years. The male to female ratio was 3:1. We have recognized three cytomorphologic patterns; purely eosinophilic, dominantly eosinophilic, and mixed inflammatory infiltrate that correlated with peripheral blood eosinophilia. Two cases demonstrated extracellular and intracellular Charcot–Leyden crystals. Certain cellular and crystal features are potential cytologic pitfalls. EEs were associated with miscellaneous specific and non‐specific medical conditions. None was associated with tuberculosis, malignancy, drugs, or parasites. Conclusions EEs are uncommon. They mostly occur in young adult males. There are three cytomorphologic patterns that correlate with peripheral eosinophilia. Etiologies are diverse or obscure. EEs with a very high eosinophilia are less likely malignant, tuberculous, parasitic, and seldom associated with drugs. Cytopathologists should be aware of certain potential diagnostic pitfalls. Correct cytologic recognition is clinically important since some causes are treatable.

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Clinicopathologic Significance of Eosinophilic Pleural Effusions in a Population with a High Prevalence of Tuberculosis and Cancer

Cited by 18 publications

References 15 publications

The Prevalence and Diagnostic Significance of Eosinophilic Pleural Effusions: A Meta-Analysis and Systematic Review

The Prevalence and Diagnostic Significance of Eosinophilic Pleural Effusions: A Meta-Analysis and Systematic Review

Drug-induced eosinophilic pleural effusion

Eosinophilic effusions: A clinicocytologic study of 12 cases

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